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Volumn 36, Issue 6, 2011, Pages

Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration

Author keywords

DCE MRI; endplate; intervertebral disc degeneration; mesenchymal stem cells; postcontrast MRI

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE ATROPHY; BONE PLATE; BONE REGENERATION; CONTROLLED STUDY; HYDROGEL; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISK; MEMBRANE PERMEABILITY; NERVE ENDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SPINAL CORD BLOOD FLOW; TISSUE PERFUSION;

EID: 79952987717     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181dce34c     Document Type: Article
Times cited : (51)

References (44)
  • 1
    • 0033554190 scopus 로고    scopus 로고
    • Epidemiological factors of chronic low-back pain
    • Anderson GB. Epidemiological factors of chronic low-back pain. Lancet 1999;354:581-5.
    • (1999) Lancet , vol.354 , pp. 581-5
    • Anderson, G.B.1
  • 2
    • 33747355707 scopus 로고    scopus 로고
    • What is intervertebral disc degeneration, and what causes it?
    • Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006;31:2151-61.
    • (2006) Spine , vol.31 , pp. 2151-61
    • Adams, M.A.1    Roughley, P.J.2
  • 3
    • 33645574432 scopus 로고    scopus 로고
    • Nutrient supply and in-tervertebral disc metabolism
    • Grunhagen T, Wilde G, Soukane DM, et al. Nutrient supply and in-tervertebral disc metabolism. J Bone Joint Surg Am 2006;88(suppl 2): 30-5.
    • (2006) J Bone Joint Surg Am , vol.88 , Issue.SUPPL. 2 , pp. 30-5
    • Grunhagen, T.1    Wilde, G.2    Soukane, D.M.3
  • 4
    • 0028323102 scopus 로고
    • A model to study the disc degeneration process
    • Natarajan RN, Ke JH, Anderson GB. A model to study the disc degeneration process. Spine 1994;19:259-65. (Pubitemid 24071105)
    • (1994) Spine , vol.19 , Issue.3 , pp. 259-265
    • Natarajan, R.N.1    Ke, J.H.2    Andersson, G.B.J.3
  • 5
    • 0029766167 scopus 로고    scopus 로고
    • The origin and fate of herniated lumbar intervertebral disc tissue
    • DOI 10.1097/00007632-199609150-00018
    • Moore RJ, Vernon-Roberts B, Fraser RD, et al. The origin of and fate of herniated lumbar intervertebral tissue. Spine 1996;21: 2149-55. (Pubitemid 26330602)
    • (1996) Spine , vol.21 , Issue.18 , pp. 2149-2155
    • Moore, R.J.1    Vernon-Roberts, B.2    Fraser, R.D.3    Osti, O.L.4    Schembri, M.5
  • 6
    • 14844362721 scopus 로고    scopus 로고
    • ISSLS Prize Winner. A study of diffusion in human lumbar discs
    • Rajasekaran S, Naresh BJ, Arun R, et al. ISSLS Prize Winner. A study of diffusion in human lumbar discs. Spine 2004;29: 2654-67.
    • (2004) Spine , vol.29 , pp. 2654-67
    • Rajasekaran, S.1    Naresh, B.J.2    Arun, R.3
  • 7
    • 14844303678 scopus 로고    scopus 로고
    • 2004 Young investigator award winner: Vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration
    • DOI 10.1097/01.brs.0000150833.93248.09
    • Benneker LM, Heini PF, Alini M, et al. 2004 young Investigator Award Winner: vertebral end-plate marrow contact channel occlu-sions and intervertebral disc degeneration. Spine 2005;30:167-73. (Pubitemid 40348204)
    • (2005) Spine , vol.30 , Issue.2 , pp. 167-173
    • Benneker, L.M.1    Heini, P.F.2    Alini, M.3    Anderson, S.E.4    Ito, K.5
  • 8
    • 28844502298 scopus 로고    scopus 로고
    • Vertebral endplate architecture and vascularization: Application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat
    • DOI 10.1097/01.brs.0000187877.30149.83
    • Gruber HE, Ashraf N, Kilburn J, et al. Vertebral endplate architec-ture and vascularization: application of micro-computed tomogra-phy, a vascular tracer and immunohistochemistry in analysis of disc degeneration in the aging sand rat. Spine 2005;30:2593-600. (Pubitemid 41780368)
    • (2005) Spine , vol.30 , Issue.23 , pp. 2593-2600
    • Gruber, H.E.1    Ashraf, N.2    Kilburn, J.3    Williams, C.4    Norton, H.J.5    Gordon, B.E.6    Hanley Jr., E.N.7
  • 9
    • 0029008944 scopus 로고
    • Aging and degeneration of the human interverte-bral disc
    • Buckwalter JA. Aging and degeneration of the human interverte-bral disc Spine 1995;20:1307-14.
    • (1995) Spine , vol.20 , pp. 1307-14
    • Buckwalter, J.A.1
  • 10
    • 0031573622 scopus 로고    scopus 로고
    • Immunohistologic markers for age-related changes of human lumbar intervertebral discs
    • DOI 10.1097/00007632-199712150-00001
    • Nerlich AG, Schleicher E, Boos N. 1997 Volvo Award Winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine 1995;22: 2781-95. (Pubitemid 28070623)
    • (1997) Spine , vol.22 , Issue.24 , pp. 2781-2795
    • Nerlich, A.G.1    Schleicher, E.D.2    Boos, N.3
  • 11
    • 43349095114 scopus 로고    scopus 로고
    • Pharmacological enhancement of disc diffusion and differentiation of healthy, age-ing and degenerated discs. Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs
    • Rajasekaran S, Venkatadass K, Babu JN, et al. Pharmacological enhancement of disc diffusion and differentiation of healthy, age-ing and degenerated discs. Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs. Eur Spine J 2008;17: 626-43
    • (2008) Eur Spine J , vol.17 , pp. 626-43
    • Rajasekaran, S.1    Venkatadass, K.2    Babu, J.N.3
  • 12
    • 23844554138 scopus 로고    scopus 로고
    • Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: Dynamic contrast-enhanced MR imaging and MR spectroscopy
    • DOI 10.1148/radiol.2363041425
    • Griffi th JF, Yeung DK, Antonio GE, et al. Vertebral bone mineral density, marrow perfusion and fat content in healthy men and men with osteoporosis. Dynamic contrast-enhanced MR imaging and MR spectroscopy. Radiology 2005;236:945-51. (Pubitemid 41170858)
    • (2005) Radiology , vol.236 , Issue.3 , pp. 945-951
    • Griffith, J.F.1    Yeung, D.K.W.2    Antonio, G.E.3    Lee, F.K.H.4    Hong, A.W.L.5    Wong, S.Y.S.6    Lau, E.M.C.7    Leung, P.C.8
  • 13
    • 52049117141 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI in Paget's disease of bone\correlation of regional microcirculation and bone turnover
    • Libicher M, Kasperk C, Daniels M, et al. Dynamic contrast-enhanced MRI in Paget's disease of bone\correlation of regional microcirculation and bone turnover. Eur Radiol 2008;18:1005-11.
    • (2008) Eur Radiol , vol.18 , pp. 1005-11
    • Libicher, M.1    Kasperk, C.2    Daniels, M.3
  • 14
    • 67349264881 scopus 로고    scopus 로고
    • Noninvasive imaging of the func-tional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model
    • Yin JJ, Tracy K, Zhang L, et al. Noninvasive imaging of the func-tional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model. Clin Exp Metastasis 2009;26:403-14.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 403-14
    • Yin, J.J.1    Tracy, K.2    Zhang, L.3
  • 15
    • 57349181441 scopus 로고    scopus 로고
    • The temporal correlation of dynamic contrast-enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model
    • Veeravagu A, Hou LC, Hsu AR, et al. The temporal correlation of dynamic contrast-enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model. Neurol Res 2008;30:952-9.
    • (2008) Neurol Res , vol.30 , pp. 952-9
    • Veeravagu, A.1    Hou, L.C.2    Hsu, A.R.3
  • 16
    • 33748521288 scopus 로고    scopus 로고
    • Senescence in human inter-vertebral discs
    • Roberts S, Evans EH, Kletsas D, et al. Senescence in human inter-vertebral discs. Eur Spine J 2006;15:3112-6.
    • (2006) Eur Spine J , vol.15 , pp. 3112-6
    • Roberts, S.1    Evans, E.H.2    Kletsas, D.3
  • 17
    • 33846652876 scopus 로고    scopus 로고
    • Senescence in cells of the aging and degenerating intervertebral disc: Immunolocalization of senescence-associated β-galactosidase in human and sand rat discs
    • DOI 10.1097/01.brs.0000253960.57051.de, PII 0000763220070201000007
    • Gruber HE, Ingram JA, Norton HJ, et al. Senescence in cells of the aging and degenerating intervertebral discs: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine 2007;32:321-7. (Pubitemid 46197471)
    • (2007) Spine , vol.32 , Issue.3 , pp. 321-327
    • Gruber, H.E.1    Ingram, J.A.2    Norton, H.J.3    Hanley Jr., E.N.4
  • 18
    • 33744477625 scopus 로고    scopus 로고
    • Effect of aging and degeneraton on disc volume and shape: A quantitative study in asymptomatic volunteers
    • DOI 10.1002/jor.20113
    • Pfirrmann CW, Metzdorf A, Elfering A, et al. Effect of aging and degeneration on disc volume and shape: a quantitative study in as-ymptomatic volunteers. J Orthop Res 2006; 1086-94. (Pubitemid 43804945)
    • (2006) Journal of Orthopaedic Research , vol.24 , Issue.5 , pp. 1086-1094
    • Pfirrmann, C.W.A.1    Metzdorf, A.2    Elfering, A.3    Hodler, J.4    Boos, N.5
  • 21
    • 57849128671 scopus 로고    scopus 로고
    • Association of 25 structur-al degradative, and infl ammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing
    • Videman T, Saarela J, Kaprio J, et al. Association of 25 structur-al degradative, and infl ammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Arthritis Rheum 2009;60:470-81.
    • (2009) Arthritis Rheum , vol.60 , pp. 470-81
    • Videman, T.1    Saarela, J.2    Kaprio, J.3
  • 22
    • 0029008944 scopus 로고
    • Spine update: Ageing and degeneration of the human intervertebral disc
    • Adams MA, Roughley PJ, Buckwalter JA. Spine update: ageing and degeneration of the human intervertebral disc Spine 1995;20: 1307-14.
    • (1995) Spine , vol.20 , pp. 1307-14
    • Adams, M.A.1    Roughley, P.J.2    Buckwalter, J.A.3
  • 23
    • 0037439062 scopus 로고    scopus 로고
    • Recent advances in disc cell biology
    • DOI 10.1097/00007632-200301150-00017
    • Gruber HE, Hanley EN Jr. Recent advances in disc cell biology. Spine 2003;28:186-93. (Pubitemid 36110088)
    • (2003) Spine , vol.28 , Issue.2 , pp. 186-193
    • Gruber, H.E.1    Hanley Jr., E.N.2
  • 24
    • 0024508629 scopus 로고
    • Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc
    • DOI 10.1097/00007632-198902000-00005
    • Roberts S, Menage J, Urban JP. Biochemical and structural proper-ties of the cartilage end-plate and its relation to the intervertebral disc Spine 1989;14:166-74. (Pubitemid 19059686)
    • (1989) Spine , vol.14 , Issue.2 , pp. 166-174
    • Roberts, S.1    Menage, J.2    Urban, J.P.G.3
  • 25
    • 0025801353 scopus 로고
    • Factors infl uencing oxygen con-centration gradients in the intervertebral disc: A theoretical analysis
    • Stairman JW, Holm S, Urban JP. Factors infl uencing oxygen con-centration gradients in the intervertebral disc: a theoretical analysis. Spine 1991;16:444-9.
    • (1991) Spine , vol.16 , pp. 444-9
    • Stairman, J.W.1    Holm, S.2    Urban, J.P.3
  • 26
    • 0018243244 scopus 로고
    • Diffusion of small solutes into the intervertebral disc: An in vivo study
    • Urban JP, Holm S, Maroudas A. Diffusion of small solutes into the intervertebral disc: an in vivo study. Biorheology 1978;15:203-21.
    • (1978) Biorheology , vol.15 , pp. 203-21
    • Urban, J.P.1    Holm, S.2    Maroudas, A.3
  • 27
    • 0033911221 scopus 로고    scopus 로고
    • Mechanical initiation of intervertebral disc degeneration
    • DOI 10.1097/00007632-200007010-00005
    • Adams MA, Freeman BJ, Morrison HP, et al. Mechanical initiation of intervertebral disc degeneration. Spine 2000;25:1625-36. (Pubitemid 30460463)
    • (2000) Spine , vol.25 , Issue.13 , pp. 1625-1636
    • Adams, M.A.1    Freeman, B.J.C.2    Morrison, H.P.3    Nelson, I.W.4    Dolan, P.5
  • 29
    • 0034659499 scopus 로고    scopus 로고
    • Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading
    • Lotz JC, Chin JR. Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading. Spine 2000;25:1477-82.
    • (2000) Spine , vol.25 , pp. 1477-82
    • Lotz, J.C.1    Chin, J.R.2
  • 30
    • 0742269711 scopus 로고    scopus 로고
    • Biological response of the intervertebral disc to dynamic loading
    • DOI 10.1016/S0021-9290(03)00290-2
    • Walsh AJ, Lotz JC. Biological response of the intervertebral disc to dynamic loading. J Biochem 2004;37:329-37. (Pubitemid 38156081)
    • (2004) Journal of Biomechanics , vol.37 , Issue.3 , pp. 329-337
    • Walsh, A.J.L.1    Lotz, J.C.2
  • 31
    • 0036894572 scopus 로고    scopus 로고
    • Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo award in basic science
    • DOI 10.1097/00007632-200212010-00002
    • Boos N, Weissbach S, Rohrbach H, et al. 2002 Volvo Award in Basic Science: classifi cation of age-related changes in lumbar inter-vertebral discs. Spine 2002;27:2631-44. (Pubitemid 35425317)
    • (2002) Spine , vol.27 , Issue.23 , pp. 2631-2644
    • Boos, N.1    Weissbach, S.2    Rohrbach, H.3    Weiler, C.4    Spratt, K.F.5    Nerlich, A.G.6
  • 32
    • 0026792914 scopus 로고
    • Annular tears and disc degeneration in the lumbar spine. A post mortem study of 135 discs
    • Osti OL, Vernon-Roberts B, Moore R, et al. Annular tears and disc degeneration in the lumbar spine. A post mortem study of 135 discs. J Bone Joint Surg 1992;74:678-82.
    • (1992) J Bone Joint Surg , vol.74 , pp. 678-82
    • Osti, O.L.1    Vernon-Roberts, B.2    Moore, R.3
  • 33
    • 0023635026 scopus 로고
    • MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease
    • de Roos A, Kressel H, Spritzer C, et al. MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease. Am J Roentgenol 1987;149:531-4. (Pubitemid 17145140)
    • (1987) American Journal of Roentgenology , vol.149 , Issue.3 , pp. 531-534
    • De Roos, A.1    Kressel, H.2    Spritzer, C.3    Dalinka, M.4
  • 34
    • 0023841473 scopus 로고
    • Degenerative disk disease: Assessment of changes in vertebral body marrow with MR imaging
    • Modic MT, Steinberg PM, Ross JS, et al. Degenerative disc disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 1988;166:193-9. (Pubitemid 18027070)
    • (1988) Radiology , vol.166 , Issue.1 , pp. 193-199
    • Modic, M.T.1    Steinberg, P.M.2    Ross, J.S.3    Masaryk, T.J.4    Carter, J.R.5
  • 37
    • 64849084387 scopus 로고    scopus 로고
    • Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla
    • Multanen J, Rauvala E, Lammentausta E, et al. Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla. Osteoarthritis Cartilage 2009;17:559-64.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 559-64
    • Multanen, J.1    Rauvala, E.2    Lammentausta, E.3
  • 39
    • 57049121084 scopus 로고    scopus 로고
    • Cell transplantation in lumbar spine disc degeneration disease
    • Hohaus C, Ganey TM, Minnkus Y, et al. Cell transplantation in lumbar spine disc degeneration disease. Eur Spine J 2008;17(suppl 4): 492-503.
    • (2008) Eur Spine J , vol.17 , Issue.SUPPL. 4 , pp. 492-503
    • Hohaus, C.1    Ganey, T.M.2    Minnkus, Y.3
  • 40
    • 0028339420 scopus 로고
    • Humoral regulation of blood flow in the vertebral endplate
    • Wallace A, Wyatt BC, McCarthy ID, et al. Humoral regulation of blood fl ow in the vertebral endplate. Spine 1994;19:1324-8. (Pubitemid 24219934)
    • (1994) Spine , vol.19 , Issue.12 , pp. 1324-1328
    • Wallace, A.L.1    Wyatt, B.C.2    McCarthy, I.D.3    Hughes, S.P.F.4
  • 41
    • 36549079657 scopus 로고    scopus 로고
    • Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport
    • DOI 10.1111/j.1469-7580.2007.00816.x
    • Werf MV, Lezuo P, Maissen O, et al. Inhibition of vertebral end-plate perfusion results in decreased intervertebral disc intranuclear diffusive transport. J Anat 2007;211:769-74. (Pubitemid 350182604)
    • (2007) Journal of Anatomy , vol.211 , Issue.6 , pp. 769-774
    • Van Der Werf, M.1    Lezuo, P.2    Maissen, O.3    Van Donkelaar, C.C.4    Ito, K.5
  • 42
    • 0036214369 scopus 로고    scopus 로고
    • The use of a quadruped as an in vivo model for the study of the spine - Biomechanical considerations
    • DOI 10.1007/s005860100346
    • Smit TH. The use of quadrupeds as an in vivo model for the study of the spine\biomechanical considerations. Eur Spine J 2002;1:137-44. (Pubitemid 34328116)
    • (2002) European Spine Journal , vol.11 , Issue.2 , pp. 137-144
    • Smit, T.H.1
  • 43
    • 0030152272 scopus 로고    scopus 로고
    • Biomechanical comparison of calf and human spines
    • DOI 10.1002/jor.1100140321
    • Wilke HJ, Krischak S, Claes L. Biomechanical comparison of calf and human spines. J Orthop Res 1996;14:500-3. (Pubitemid 26199840)
    • (1996) Journal of Orthopaedic Research , vol.14 , Issue.3 , pp. 500-503
    • Wilke, H.-J.1    Krischak, S.2    Claes, L.3
  • 44
    • 0031284671 scopus 로고    scopus 로고
    • Are sheep shines a valid biomechanical model for human spines?
    • DOI 10.1097/00007632-199710150-00009
    • Wilke HJ, Kettler A, Claes L. Are sheep spines a valid model for human spines. Spine 1997;22:2365-74. (Pubitemid 28069105)
    • (1997) Spine , vol.22 , Issue.20 , pp. 2365-2374
    • Wilke, H.-J.1    Kettler, A.2    Claes, L.E.3


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