-
1
-
-
84860202788
-
Cardiovascular toxicity associated with small molecule tyrosine kinase inhibitors currently in clinical use
-
C.A. Dasanu, P. Padmanabhan, B.A. Clark 3rd, C. Do Cardiovascular toxicity associated with small molecule tyrosine kinase inhibitors currently in clinical use Expert Opin Drug Saf 11 2012 445 457
-
(2012)
Expert Opin Drug Saf
, vol.11
, pp. 445-457
-
-
Dasanu, C.A.1
Padmanabhan, P.2
Clark III, B.A.3
Do, C.4
-
2
-
-
80655127883
-
Cardiac side effects of molecular targeted therapies: Towards a better dialogue between oncologists and cardiologists
-
S. Ederhy, H. Izzedine, C. Massard Cardiac side effects of molecular targeted therapies: towards a better dialogue between oncologists and cardiologists Crit Rev Oncol Hematol 80 2011 369 379
-
(2011)
Crit Rev Oncol Hematol
, vol.80
, pp. 369-379
-
-
Ederhy, S.1
Izzedine, H.2
Massard, C.3
-
3
-
-
0037032835
-
The protein kinase complement of the human genome
-
G. Manning, D.B. Whyte, R. Martinez, T. Hunter, S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
4
-
-
79551610758
-
Cardiotoxicity of kinase inhibitors: The prediction and translation of preclinical models to clinical outcomes
-
T. Force, K.L. Kolaja Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes Nat Rev Drug Discov 10 2011 111 126
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 111-126
-
-
Force, T.1
Kolaja, K.L.2
-
6
-
-
78650383580
-
Cardiovascular side effects of cancer therapies: A position statement from the Heart Failure Association of the European Society of Cardiology
-
T. Eschenhagen, T. Force, M.S. Ewer Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail 13 2011 1 10
-
(2011)
Eur J Heart Fail
, vol.13
, pp. 1-10
-
-
Eschenhagen, T.1
Force, T.2
Ewer, M.S.3
-
8
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
R. Kerkela, L. Grazette, R. Yacobi Cardiotoxicity of the cancer therapeutic agent imatinib mesylate Nat Med 12 2006 908 916
-
(2006)
Nat Med
, vol.12
, pp. 908-916
-
-
Kerkela, R.1
Grazette, L.2
Yacobi, R.3
-
9
-
-
36849023013
-
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
-
T.F. Chu, M.A. Rupnick, R. Kerkela Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib Lancet 370 2007 2011 2019
-
(2007)
Lancet
, vol.370
, pp. 2011-2019
-
-
Chu, T.F.1
Rupnick, M.A.2
Kerkela, R.3
-
10
-
-
84863041902
-
Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors
-
R.M. Steingart, G.L. Bakris, H.X. Chen Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors Am Heart J 163 2012 156 163
-
(2012)
Am Heart J
, vol.163
, pp. 156-163
-
-
Steingart, R.M.1
Bakris, G.L.2
Chen, H.X.3
-
11
-
-
77952038495
-
Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors
-
M.L. Maitland, G.L. Bakris, H.R. Black Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors J Natl Cancer Inst 102 2010 596 604
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 596-604
-
-
Maitland, M.L.1
Bakris, G.L.2
Black, H.R.3
-
12
-
-
79953158399
-
Exploring the genomes of cancer cells: Progress and promise
-
M.R. Stratton Exploring the genomes of cancer cells: progress and promise Science 331 2011 1553 1558
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
13
-
-
33646690478
-
Kinase mutations in cancer: Chinks in the enemy's armour?
-
F. Di Nicolantonio, A. Bardelli Kinase mutations in cancer: chinks in the enemy's armour? Curr Opin Oncol 18 2006 69 76
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 69-76
-
-
Di Nicolantonio, F.1
Bardelli, A.2
-
15
-
-
72849159485
-
Chromosome studies on normal and leukemic human leukocytes
-
P.C. Nowell, D.A. Hungerford Chromosome studies on normal and leukemic human leukocytes J Natl Cancer Inst 25 1960 85 109
-
(1960)
J Natl Cancer Inst
, vol.25
, pp. 85-109
-
-
Nowell, P.C.1
Hungerford, D.A.2
-
16
-
-
0017250977
-
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
-
D. Stehelin, H.E. Varmus, J.M. Bishop, P.K. Vogt DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA Nature 260 1976 170 173
-
(1976)
Nature
, vol.260
, pp. 170-173
-
-
Stehelin, D.1
Varmus, H.E.2
Bishop, J.M.3
Vogt, P.K.4
-
17
-
-
67349262466
-
Cancer driver mutations in protein kinase genes
-
A. Torkamani, G. Verkhivker, N.J. Schork Cancer driver mutations in protein kinase genes Cancer Lett 281 2009 117 127
-
(2009)
Cancer Lett
, vol.281
, pp. 117-127
-
-
Torkamani, A.1
Verkhivker, G.2
Schork, N.J.3
-
19
-
-
0019474922
-
Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
-
C. Shih, L.C. Padhy, M. Murray, R.A. Weinberg Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts Nature 290 1981 261 264
-
(1981)
Nature
, vol.290
, pp. 261-264
-
-
Shih, C.1
Padhy, L.C.2
Murray, M.3
Weinberg, R.A.4
-
20
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
C. Greenman, P. Stephens, R. Smith Patterns of somatic mutation in human cancer genomes Nature 446 2007 153 158
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
-
21
-
-
79951865370
-
Clinical implications of the cancer genome
-
L.E. Macconaill, L.A. Garraway Clinical implications of the cancer genome J Clin Oncol 28 2010 5219 5228
-
(2010)
J Clin Oncol
, vol.28
, pp. 5219-5228
-
-
MacConaill, L.E.1
Garraway, L.A.2
-
22
-
-
41649109807
-
Translating insights from the cancer genome into clinical practice
-
L. Chin, J.W. Gray Translating insights from the cancer genome into clinical practice Nature 452 2008 553 563
-
(2008)
Nature
, vol.452
, pp. 553-563
-
-
Chin, L.1
Gray, J.W.2
-
24
-
-
57549098807
-
The Catalogue of Somatic Mutations in Cancer (COSMIC)
-
Chapter 10:Unit 10.11
-
S.A. Forbes, G. Bhamra, S. Bamford The Catalogue of Somatic Mutations in Cancer (COSMIC) Curr Protoc Hum Genet 2008 Chapter 10:Unit 10.11
-
(2008)
Curr Protoc Hum Genet
-
-
Forbes, S.A.1
Bhamra, G.2
Bamford, S.3
-
25
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
L.D. Wood, D.W. Parsons, S. Jones The genomic landscapes of human breast and colorectal cancers Science 318 2007 1108 1113
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
-
27
-
-
77956838065
-
Advances in understanding cancer genomes through second-generation sequencing
-
M. Meyerson, S. Gabriel, G. Getz Advances in understanding cancer genomes through second-generation sequencing Nat Rev Genet 11 2010 685 696
-
(2010)
Nat Rev Genet
, vol.11
, pp. 685-696
-
-
Meyerson, M.1
Gabriel, S.2
Getz, G.3
-
28
-
-
79960687447
-
New DNA sequencing technologies open a promising era for cancer research and treatment
-
L. Sastre New DNA sequencing technologies open a promising era for cancer research and treatment Clin Transl Oncol 13 2011 301 306
-
(2011)
Clin Transl Oncol
, vol.13
, pp. 301-306
-
-
Sastre, L.1
-
29
-
-
0005953097
-
Protein kinase activity associated with the avian sarcoma virus src gene product
-
M.S. Collett, R.L. Erikson Protein kinase activity associated with the avian sarcoma virus src gene product Proc Natl Acad Sci U S A 75 1978 2021 2024
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, pp. 2021-2024
-
-
Collett, M.S.1
Erikson, R.L.2
-
30
-
-
0018071189
-
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
-
A.D. Levinson, H. Oppermann, L. Levintow, H.E. Varmus, J.M. Bishop Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein Cell 15 1978 561 572
-
(1978)
Cell
, vol.15
, pp. 561-572
-
-
Levinson, A.D.1
Oppermann, H.2
Levintow, L.3
Varmus, H.E.4
Bishop, J.M.5
-
31
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
S.J. Heidorn, C. Milagre, S. Whittaker Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 2010 209 221
-
(2010)
Cell
, vol.140
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
-
32
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
J. Zhang, P.L. Yang, N.S. Gray Targeting cancer with small molecule kinase inhibitors Nat Rev Cancer 9 2009 28 39
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
33
-
-
4444353636
-
Regulation of protein kinases; Controlling activity through activation segment conformation
-
B. Nolen, S. Taylor, G. Ghosh Regulation of protein kinases; controlling activity through activation segment conformation Mol Cell 15 2004 661 675
-
(2004)
Mol Cell
, vol.15
, pp. 661-675
-
-
Nolen, B.1
Taylor, S.2
Ghosh, G.3
-
34
-
-
58149199567
-
MoKCa database - Mutations of kinases in cancer
-
C.J. Richardson, Q. Gao, C. Mitsopoulous, M. Zvelebil, L.H. Pearl, F.M. Pearl MoKCa database - mutations of kinases in cancer Nucleic Acids Res 37 2009 D824 D831
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Richardson, C.J.1
Gao, Q.2
Mitsopoulous, C.3
Zvelebil, M.4
Pearl, L.H.5
Pearl, F.M.6
-
35
-
-
79960122936
-
A new frontier in personalized cancer therapy: Mapping molecular changes
-
K. Kasaian, S.J. Jones A new frontier in personalized cancer therapy: mapping molecular changes Future Oncol 7 2011 873 894
-
(2011)
Future Oncol
, vol.7
, pp. 873-894
-
-
Kasaian, K.1
Jones, S.J.2
-
37
-
-
50949132320
-
Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics
-
M.H. Chen, R. Kerkela, T. Force Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics Circulation 118 2008 84 95
-
(2008)
Circulation
, vol.118
, pp. 84-95
-
-
Chen, M.H.1
Kerkela, R.2
Force, T.3
-
38
-
-
74049125665
-
Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics
-
H. Cheng, T. Force Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics Circ Res 106 2010 21 34
-
(2010)
Circ Res
, vol.106
, pp. 21-34
-
-
Cheng, H.1
Force, T.2
-
39
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Z.A. Knight, H. Lin, K.M. Shokat Targeting the cancer kinome through polypharmacology Nat Rev Cancer 10 2010 130 137
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
40
-
-
75749146563
-
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
-
J. Zhang, F.J. Adrian, W. Jahnke Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors Nature 463 2010 501 506
-
(2010)
Nature
, vol.463
, pp. 501-506
-
-
Zhang, J.1
Adrian, F.J.2
Jahnke, W.3
-
42
-
-
9644295769
-
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
-
O. Yamaguchi, T. Watanabe, K. Nishida Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis J Clin Invest 114 2004 937 943
-
(2004)
J Clin Invest
, vol.114
, pp. 937-943
-
-
Yamaguchi, O.1
Watanabe, T.2
Nishida, K.3
-
43
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
B. Escudier, T. Eisen, W.M. Stadler Sorafenib in advanced clear-cell renal-cell carcinoma N Engl J Med 356 2007 125 134
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
44
-
-
36849056267
-
An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic
-
A. Fernandez, A. Sanguino, Z. Peng An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic J Clin Invest 117 2007 4044 4054
-
(2007)
J Clin Invest
, vol.117
, pp. 4044-4054
-
-
Fernandez, A.1
Sanguino, A.2
Peng, Z.3
-
45
-
-
77950042300
-
The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity
-
B.B. Hasinoff The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity Toxicol Appl Pharmacol 244 2010 190 195
-
(2010)
Toxicol Appl Pharmacol
, vol.244
, pp. 190-195
-
-
Hasinoff, B.B.1
-
47
-
-
77957680164
-
Differences in effects on myocardium and mitochondria by angiogenic inhibitors suggest separate mechanisms of cardiotoxicity
-
K.J. French, R.W. Coatney, J.P. Renninger Differences in effects on myocardium and mitochondria by angiogenic inhibitors suggest separate mechanisms of cardiotoxicity Toxicol Pathol 38 2010 691 702
-
(2010)
Toxicol Pathol
, vol.38
, pp. 691-702
-
-
French, K.J.1
Coatney, R.W.2
Renninger, J.P.3
-
48
-
-
84856104973
-
A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity
-
H. Cheng, G. Kari, A.P. Dicker, U. Rodeck, W.J. Koch, T. Force A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity Circ Res 109 2011 1401 1409
-
(2011)
Circ Res
, vol.109
, pp. 1401-1409
-
-
Cheng, H.1
Kari, G.2
Dicker, A.P.3
Rodeck, U.4
Koch, W.J.5
Force, T.6
-
49
-
-
79955482429
-
Opportunities for use of human iPS cells in predictive toxicology
-
B.D. Anson, K.L. Kolaja, T.J. Kamp Opportunities for use of human iPS cells in predictive toxicology Clin Pharmacol Ther 89 2011 754 758
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. 754-758
-
-
Anson, B.D.1
Kolaja, K.L.2
Kamp, T.J.3
-
50
-
-
84863888089
-
Determination of the human cardiomyocyte mRNA and miRNA differentiation network by fine-scale profiling
-
J.E. Babiarz, M. Ravon, S. Sridhar Determination of the human cardiomyocyte mRNA and miRNA differentiation network by fine-scale profiling Stem Cells Dev 21 2012 1956 1965
-
(2012)
Stem Cells Dev
, vol.21
, pp. 1956-1965
-
-
Babiarz, J.E.1
Ravon, M.2
Sridhar, S.3
-
51
-
-
77951640385
-
Human embryonic stem cell-derived cardiomyocytes: Demonstration of a portion of cardiac cells with fairly mature electrical phenotype
-
M. Pekkanen-Mattila, H. Chapman, E. Kerkela Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype Exp Biol Med (Maywood) 235 2010 522 530
-
(2010)
Exp Biol Med (Maywood)
, vol.235
, pp. 522-530
-
-
Pekkanen-Mattila, M.1
Chapman, H.2
Kerkela, E.3
-
52
-
-
81255142147
-
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations
-
J.D. Cohen, J.E. Babiarz, R.M. Abrams Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations Toxicol Appl Pharmacol 257 2011 74 83
-
(2011)
Toxicol Appl Pharmacol
, vol.257
, pp. 74-83
-
-
Cohen, J.D.1
Babiarz, J.E.2
Abrams, R.M.3
-
53
-
-
84857963032
-
Evaluation of drugs with specific organ toxicities in organ-specific cell lines
-
Z. Lin, Y. Will Evaluation of drugs with specific organ toxicities in organ-specific cell lines Toxicol Sci 126 2012 114 127
-
(2012)
Toxicol Sci
, vol.126
, pp. 114-127
-
-
Lin, Z.1
Will, Y.2
-
54
-
-
80051725475
-
Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics
-
R.E. Gerszten, A. Asnani, S.A. Carr Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics Circ Res 109 2011 463 474
-
(2011)
Circ Res
, vol.109
, pp. 463-474
-
-
Gerszten, R.E.1
Asnani, A.2
Carr, S.A.3
-
55
-
-
79954593490
-
Early detection and prediction of cardiotoxicity in chemotherapy-treated patients
-
H. Sawaya, I.A. Sebag, J.C. Plana Early detection and prediction of cardiotoxicity in chemotherapy-treated patients Am J Cardiol 107 2011 1375 1380
-
(2011)
Am J Cardiol
, vol.107
, pp. 1375-1380
-
-
Sawaya, H.1
Sebag, I.A.2
Plana, J.C.3
|