CEACAM1 inhibits cell-matrix adhesion and promotes cell migration through regulating the expression of N-cadherin

Biochemical and Biophysical Research Communications

Volumn 430, Issue 2, 2013, Pages 598-603

  Liu, Jin ^a   Di, Guohu ^a   Wu, Chu Tse ^a,c   Hu, Xianwen ^b   Duan, Haifeng ^c  

^a TIANJIN UNIVERSITY   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

CEACAM1; Cell matrix adhesion; Migration; N cadherin

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; NERVE CELL ADHESION MOLECULE; SMALL INTERFERING RNA;

ARTICLE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REPORTER GENE;

ANTIGENS, CD; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; HEK293 CELLS; HT29 CELLS; HUMANS; MODELS, BIOLOGICAL; NEOPLASM METASTASIS;

EID: 84872330545     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.107     Document Type: Article

References (15)

1. Gray-Owen S.D., Blumberg R.S. CEACAM1: contact-dependent control of immunity. Nat. Rev. Immunol. 2006, 6:433-446.
2. Ebrahimnejad A., Streichert T., Nollau P., Horst A.K., Wagener C., Bamberger A.M., Brümmer J. CEACAM1 enhances invasion and migration of melanocytic and melanoma cells. Am. J. pathol. 2004, 165:1781-1787.
3. Ieda J., Yokoyama S., Tamura K., Takifuji K., Hotta T., Matsuda K., Oku Y., Nasu T., Kiriyama S., Yamamoto N., Nakamura Y., Shively J.E., Yamaue H. Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer. Int. J. Cancer 2011, 129:1351-1361.
4. Luo W., Tapolsky M., Earley K., Wood C.G., Wilson D.R., Logothetis C.J., Lin S.H. Tumor-suppressive activity of CD66a in prostate cancer. Cancer gene ther. 1999, 6:313.
5. Cruz P.V., Wakai T., Shirai Y., Yokoyama N., Hatakeyama K. Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma. Cancer 2005, 104:354-360.
6. Xi L., Feber A., Gupta V., Wu M., Bergemann A.D., Landreneau R.J., Litle V.R., Pennathur A., Luketich J.D., Godfrey T.E. Whole genome exon arrays identify differential expression of alternatively, spliced cancer-related genes in lung cancer. Nucleic Acids Res. 2008, 36:6535-6547.
7. Markel G., Ortenberg R., Seidman R., Sapoznik S., Koren-Morag N., Besser M.J., Bar J., Shapira R., Kubi A., Nardini G., Tessone A., Treves A.J., Winkler E., Orenstein A., Schachter J. Systemic dysregulation of CEACAM1 in melanoma patients. Cancer Immunol. Immunother. 2010, 59:215-230.
8. Moh M.C., Shen S. The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox. Cell Adh. Migr. 2009, 3:334-336.
9. Kang W.Y., Chen W.T., Wu M.T., Chai C.Y. The expression of CD66a and possible roles in colorectal adenoma and adenocarcinoma. Int. J. Colorectal Dis. 2007, 22:869-874.
10. Thom I., Schult-Kronefeld O., Burkholder I., Schuch G., Andritzky B., Kastendieck H., Edler L., Wagener C., Bokemeyer C., Schumacher U., Laack E. Expression of CEACAM-1 in pulmonary adenocarcinomas and their metastases. Anticancer Res. 2009, 29:249-254.
11. Arabzadeh A., Chan C., Nouvion A.L., Breton V., Benlolo S., Demarte L., Turbide C., Brodt P., Ferri L., Beauchemin N. Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. Oncogene 2012.
12. Derycke L.D., Bracke M.E. N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Int. J. Dev. Biol. 2004, 48:463-476.
13. Blindt R., Bosserhoff A.K., Dammers J., Krott N., Demircan L., Hoffmann R., Hanrath P., Weber C., Vogt F. Downregulation of N-cadherin in the neointima stimulates migration of smooth muscle cells by RhoA deactivation. Cardiovasc. Res. 2004, 62:212-222.
14. Nollau P., Scheller H., Kona-Horstmann M., Rohde S., Hagenmuller F., Wagener C., Neumaier M. Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas. Cancer Res. 1997, 57:2354-2357.
15. Choi S.S., Diehl A.M. Epithelial-to-mesenchymal transitions in the liver. Hepatology 2009, 50:2007-2013.