Aldol reactions of 2-thioxotetrahydropyrimidin-4(1H)-ones: Stereoregulations from endo- and exocyclic chiral centres

Tetrahedron

Volumn 69, Issue 6, 2013, Pages 1747-1754

  Kumar, Varun ^a   Kumar, Kapil ^a   Pal, Anang ^a   Khatik, Gopal Lal ^a   Nair, Vipin A ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

2 Thioxotetrahydropyrimidin 4(1H) one; Aldol; Chiral induction; Cyclic enolate; Diastereoselectivity

Indexed keywords

3 (3 CHLORO 4 CYANOPHENYL) 5 ((4 CHLOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (3 CHLORO 4 CYANOPHENYL) 5 (4 FLUOROPHENYL)(HYDROXY)METHLY 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 ((4 CHLOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 ((4 FLUOROPHENYL)HYDROXY)METHYL 1(1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 (4 FLUOROPHENYL)HYDROXY)METHYL 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (3 CHLORO 4 FLUOROPHENYL) 5-((4 CHLOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL) 5 ((4 CHLOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL) 5 ((4 FLUOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL) 5 (4 CHLOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL) 5 ((4 CHLOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL) 5 ((4 FLUOROPHENYL)(HYDROXY)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL) 5 ((FURAN 2 YL(HYDROXY)METHYL)) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL) 5 ((HYDROXY)(PHENYL)METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL) 5 (1 HYDROXY 3 PHENYLALLYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 (4 CHLOROPHENYL)5 ((4 CHLOROPHENYL)(HYDROXY) METHYL) 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 ARYL 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; 3 ARYL 6 METHYL 1 (1 PHENYLETHYL) 2 THIOXOTETRAHHYDROPYRIMIDIN 4(1H) ONE; 3 ARYL 6 METHYL 1 (1 PHENYLETHYL) 2 THIOXOTETRAHYDROPYRIMIDIN 4(1H) ONE; ANTIDIABETIC AGENT; BENZALDEHYDE; FLUOROURACIL; HERBICIDE; LAMIVUDINE; LITHIUM; METHYL GROUP; PYRIMIDINE DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URAMUSTINE;

ALDOL REACTION; ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; KINETICS; NUCLEAR MAGNETIC RESONANCE; ONE POT SYNTHESIS; PRIORITY JOURNAL; STEREOCHEMISTRY; X RAY ANALYSIS;

EID: 84872329193     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.12.020     Document Type: Article

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