Autologous stem cells in neurology: Is there a future?

Journal of Neural Transmission

Volumn 120, Issue 1, 2013, Pages 65-73

  De Munter, Johannes P J M ^a   Wolters, Erik C ^b,c  

^a Amarna Stem Cells ^*  (Spain)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Autologous; Intrathecal; Mesenchymal; Mononuclear Cells; Regeneration; Stem cells

Indexed keywords

CD34 ANTIGEN; CILIARY NEUROTROPHIC FACTOR; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FORSKOLIN; GAMMA INTERFERON; SOMATOMEDIN C; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ALLERGIC ENCEPHALOMYELITIS; ALLOGENEIC STEM CELL TRANSPLANTATION; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; AUTOLOGOUS STEM CELL TRANSPLANTATION; B LYMPHOCYTE; BIOSAFETY; BONE MARROW BIOPSY; CARCINOGENESIS; CELL DIFFERENTIATION; CELL TRANSDIFFERENTIATION; EMBRYONIC STEM CELL; FOOD AND DRUG ADMINISTRATION; GLIA CELL; HEMATOPOIETIC STEM CELL; IMMUNE RESPONSE; IMMUNOMODULATION; INHIBITION KINETICS; LYMPHOCYTE PROLIFERATION; MEDICAL SOCIETY; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; T LYMPHOCYTE; UMBILICAL CORD; UPREGULATION;

ADULT STEM CELLS; ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; HUMANS; NERVOUS SYSTEM DISEASES; STEM CELL TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS;

EID: 84872325353     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0913-9     Document Type: Review

References (63)

1. Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822 (Pubitemid 40223708)
2. Andersson AK (2011) Embryonic stem cells and property rights. J med philos 36:221-242
3. Andres RH, Choi R, Steinberg GK, Guzman R (2008) Potential of adult neural stem cells in stroke therapy. Regen med 3:893-905
4. Assmus B, Rolf A, Erbs S et al (2010) Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction. Circ Heart Fail 3:89-96
5. Astori G, Soncin S, Lo Cicero V, Siclari F, Surder D, Turchetto L, Soldati G, Moccetti T (2010) Bone marrow derived stem cells in regenerative medicine as advanced therapy medicinal products. Am J Transl Res 2:285-295
6. Asumda FZ, Chase PB (2011) Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biol 12:44
7. Bakshi A, Barshinger AL, Swanger SA, Madhavani V, Shumsky JS, Neuhuber B, Fischer I (2006) Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation. J Neurotrauma 23:55-65 (Pubitemid 43191086)
8. Barzilay R, Levy YS, Melamed E, Offen D (2006) Adult stem cells for neuronal repair. Isr Med Assoc J IMAJ 8:61-66 (Pubitemid 43116072)
9. Bouchez G, Sensebe L, Vourc'h P et al (2008) Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease. Neurochem Int 52:1332-1342
10. Chan JL, Tang KC, Patel AP, Bonilla LM, Pierobon N, Ponzio NM, Rameshwar P (2006) Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood 107:4817-4824 (Pubitemid 43882633)
11. Cho GW, Noh MY, Kim HY, Koh SH, Kim KS, Kim SH (2010) Bone marrow-derived stromal cells from amyotrophic lateral sclerosis patients have diminished stem cell capacity. Stem Cells Dev 19:1035-1042
12. Courtine G, Bunge MB, Fawcett JW et al (2007) Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat Med 13:561-566 (Pubitemid 46828491)
13. Crigler L, Robey RC, Asawachaicharn A, Gaupp D, Phinney DG (2006) Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol 198:54-64 (Pubitemid 43243744)
14. Dezawa M, Kanno H, Hoshino M et al (2004) Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Investig 113:1701-1710 (Pubitemid 39071662)
15. Dimmeler S, Leri A (2008) Aging and disease as modifiers of efficacy of cell therapy. Circ Res 102:1319-1330
16. Dominici M, Le Blanc K, Mueller I et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8:315-317 (Pubitemid 44269669)
17. Forostyak S, Jendelova P, Kapcalova M, Arboleda D, Sykova E (2011) Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. Cytotherapy 13:1036-1046
18. Gerdoni E, Gallo B, Casazza S et al (2007) Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann neurol 61:219-227 (Pubitemid 46557346)
19. Gnecchi M, Zhang Z, Ni A, Dzau VJ (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103:1204-1219
20. Hemmat S, Lieberman DM, Most SP (2010) An introduction to stem cell biology. Facial plast surg FPS 26:343-349
21. Holowiecki J (2008) Indications for hematopoietic stem cell transplantation. Pol Arch Med Wewn 118:658-663
22. Huang X, Kim JM, Kong TH (2009) GM-CSF inhibits glial scar formation and shows long-term protective effect after spinal cord injury. J Neurol Sci 277:87-97
23. Jackson JS, Golding JP, Chapon C, Jones WA, Bhakoo KK (2010) Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study. Stem Cell Res Ther 1:17
24. Jung D, Ha IJ, Kang BT, Kim JW, Quan FS, Lee JH, Woo EJ, Park HM (2009) A comparison of autologous and allogenic bone marrow-derived mesenchymal stem cell transplantation in canine spinal cord injury. J Neurol Sci 285:67-77
25. Junker JP, Sommar P, Skog M, Johnson H, Kratz G (2010) Adipogenic, chondrogenic and osteogenic differentiation of clonally derived human dermal fibroblasts. Cells Tissues Organs 191:105-118
26. Kamei N, Tanaka N, Oishi Y, Hamasaki T, Nakanishi K, Sakai N, Ochi M (2007) BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures. Spine 32:1272-1278 (Pubitemid 46791444)
27. Kassis I, Grigoriadis N, Gowda-Kurkalli B, Mizrachi-Kol R, Ben-Hur T, Slavin S, Abramsky O, Karussis D (2008) Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis. Arch Neurol 65:753-761 (Pubitemid 351831453)
28. Keeney M, Chin-Yee I, Weir K, Popma J, Nayar R, Sutherland DR (1998) Single platform flow cytometric absolute CD34 + cell counts based on the ISHAGE guidelines. International Society of Hematotherapy and Graft Engineering. Cytometry 34:61-70
29. Koshizuka S, Okada S, Okawa A et al (2004) Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice. J Neuropathol Exp Neurol 63:64-72 (Pubitemid 38030234)
30. Kumar AA, Kumar SR, Narayanan R, Arul K, Baskaran M (2009) Autologous bone marrow derived mononuclear cell therapy for spinal cord injury: a phase I/II clinical safety and primary efficacy data. Exp Clin Transplant Off J Middle East Soc Organ Transplant 7:241-248
31. Lee AS, Tang C, Cao F et al (2009) Effects of cell number on teratoma formation by human embryonic stem cells. Cell Cycle 8:2608-2612
32. Levy YS, Bahat-Stroomza M, Barzilay R et al (2008) Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease. Cytotherapy 10:340-352 (Pubitemid 351983158)
33. Li J, Zhu H, Liu Y et al (2010a) Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macaca fascicularis. Brain Res 1334:65-72
34. Li TS, Kubo M, Ueda K, Murakami M, Mikamo A, Hamano K (2010b) Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure. J Thorac Cardiovasc Surg 139:459-465
35. Mayshar Y, Ben-David U, Lavon N et al (2010) Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell 7:521-531
36. Neuhuber B, Himes BT, Shumsky JS, Gallo G, Fischer I (2005) Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 1035:73-85 (Pubitemid 40248539)
37. Pittenger MF, Martin BJ (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95:9-20 (Pubitemid 38931831)
38. Pittenger MF, Mackay AM, Beck SC et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147 (Pubitemid 29282067)
39. Riordan NH, Chan K, Marleau AM, Ichim TE (2007) Cord blood in regenerative medicine: do we need immune suppression? J Transl Med 5:8
40. Samdani AF, Paul C, Betz RR, Fischer I, Neuhuber B (2009) Transplantation of human marrow stromal cells and mono-nuclear bone marrow cells into the injured spinal cord: a comparative study. Spine 34:2605-2612
41. Sato K, Ozaki K, Oh I, Meguro A, Hatanaka K, Nagai T, Muroi K, Ozawa K (2007) Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109:228-234 (Pubitemid 46053063)
42. Scerpa MC, Daniele N, Landi F et al (2011) Automated washing of human progenitor cells: evaluation of apoptosis and cell necrosis. Transfus Med 21:402-407
43. Schofield R (1983) The stem cell system. Biomed Pharmacother 37:375-380 (Pubitemid 14194496)
44. Sekhon LH, Fehlings MG (2001) Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine (Phila Pa 1976) 26:S2-S12
45. Shi E, Kazui T, Jiang X, Washiyama N, Yamashita K, Terada H, Bashar AH (2007) Therapeutic benefit of intrathecal injection of marrow stromal cells on ischemia-injured spinal cord. Ann Thorac Surg 83:1484-1490 (Pubitemid 46440774)
46. Siddiq S, Pamphilon D, Brunskill S, Doree C, Hyde C, Stanworth A (2009) Bone marrow harvest versus peripheral stem cell collection for haemopoietic stem cell donation in healthy donors. Cochrane Database Syst Rev, 21(1):CD006406
47. Stadtfeld M, Hochedlinger K (2010) Induced pluripotency: history, mechanisms, and applications. Genes Dev 24:2239-2263
48. Stamatovic SM, Keep RF, Andjelkovic AV (2008) Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol 6:179-192
49. Stenderup K, Justesen J, Clausen C, Kassem M (2003) Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 33:919-926 (Pubitemid 37543568)
50. Taguchi A, Soma T, Tanaka H (2004) Administration of CD34 + cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 114:330-338 (Pubitemid 39071605)
51. Van Tongeren RB, Hamming JF, Fibbe WE, Van Weel V, Frerichs SJ, Stiggelbout AM, Van Bockel JH, Lindeman JH (2008) Intramuscular or combined intramuscular/intra-arterial administration of bone marrow mononuclear cells: a clinical trial in patients with advanced limb ischemia. J Cardiovasc Surg (Torino) 49:51-58 (Pubitemid 351350807)
52. Veeraputhiran M, Theus JW, Pesek G, Barlogie B, Cottler-Fox M (2010) Viability and engraftment of hematopoietic progenitor cells after long-term cryopreservation: effect of diagnosis and percentage dimethyl sulfoxide concentration. Cytotherapy 12:764-766
53. Wragg A, Mellad JA, Beltran LE et al (2008) VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism. J Mol Med 86:1221-1232
54. Wright KT, El Masri W, Osman A, Chowdhury J, Johnson WE (2010) Bone marrow for the treatment of spinal cord injury: mechanisms and clinical application. Stem Cells 29(2):169-178
55. Wyndaele M, Wyndaele JJ (2006) Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord 44:523-529 (Pubitemid 44338756)
56. Xu H, Miki K, Ishibashi S et al (2010) Transplantation of neuronal cells induced from human mesenchymal stem cells improves neurological functions after stroke without cell fusion. J Neurosci Res 88:3598-3609
57. Yang B, Strong R, Sharma S et al (2011) Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke. J Neurosci Res 89:833-839
58. Ye Y, Zeng YM, Wan MR, Lu XF (2011) Induction of human bone marrow mesenchymal stem cells differentiation into neural-like cells using cerebrospinal fluid. Cell Biochem Biophys 59:179-184
59. Zappia E, Casazza S, Pedemonte E et al (2005) Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106:1755-1761 (Pubitemid 41208591)
60. Zeng R, Wang LW, Hu ZB et al (2011) Differentiation of human bone marrow mesenchymal stem cells into neuron-like cells in vitro. Spine (Phila Pa 1976) 36(13):997-1005
61. Zhang J, Li Y, Chen J et al (2005) Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp Neurol 195:16-26 (Pubitemid 41116810)
62. Zhang C, Zhou C, Teng JJ, Zhao RL, Song YQ (2009) Multiple administrations of human marrow stromal cells through cerebrospinal fluid prolong survival in a transgenic mouse model of amyotrophic lateral sclerosis. Cytotherapy 11:299-306
63. Zietlow R, Lane EL, Dunnett SB, Rosser AE (2008) Human stem cells for CNS repair. Cell Tissue Res 331:301-322 (Pubitemid 350265495)