메뉴 건너뛰기




Volumn , Issue , 2008, Pages 123-157

Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis

Author keywords

Hybrid QQQ LIT instruments and IDA experiment; Ion trap and linear ion trap theory; Quadrupole, triple quadrupole, and hybrid linear ion

Indexed keywords


EID: 84872323249     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470409817.ch3     Document Type: Chapter
Times cited : (1)

References (32)
  • 3
    • 0035416421 scopus 로고    scopus 로고
    • Systematic LC/MS metabolite identification in drug discovery
    • Clarke, N. J., Rindgen, D., Korfmacher, W. A., and Cox, K. A. (2001). Systematic LC/MS metabolite identification in drug discovery. Anal. Chem. 73:430A-439A.
    • (2001) Anal. Chem. , vol.73
    • Clarke, N.J.1    Rindgen, D.2    Korfmacher, W.A.3    Cox, K.A.4
  • 5
    • 44049116161 scopus 로고
    • Collisional focusing effects in radio frequency quadrupoles
    • Douglas, D. J., and French, J. B. (1992). Collisional focusing effects in radio frequency quadrupoles. J. Am. Soc. Mass Spectrom. 3:398-408.
    • (1992) J. Am. Soc. Mass Spectrom. , vol.3 , pp. 398-408
    • Douglas, D.J.1    French, J.B.2
  • 6
    • 0041918439 scopus 로고    scopus 로고
    • Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates
    • Fernandez-Metzler, C. L., Owens, K. G., Baillie, T. A., and King, R. C. (1999). Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates. Drug Metab. Dispos. 27:32-40.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 32-40
    • Fernandez-Metzler, C.L.1    Owens, K.G.2    Baillie, T.A.3    King, R.C.4
  • 7
    • 0036199431 scopus 로고    scopus 로고
    • A new linear ion trap mass spectrometer
    • Hager, J.W. (2002). A new linear ion trap mass spectrometer. Rapid Commun. Mass Spectrom. 16:512-526.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 512-526
    • Hager, J.W.1
  • 8
    • 0038788809 scopus 로고    scopus 로고
    • Product ion spectral simplification using time-delayed fragment ion capture with tandem linear ion traps
    • Hager, J. W. (2003). Product ion spectral simplification using time-delayed fragment ion capture with tandem linear ion traps. Rapid Commun. Mass Spectrom. 17:1389-1398.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 1389-1398
    • Hager, J.W.1
  • 9
    • 4444318037 scopus 로고    scopus 로고
    • Recent trends in mass spectrometer development
    • Hager, J. W. (2004). Recent trends in mass spectrometer development. Anal. Bioanal. Chem. 378:845-850.
    • (2004) Anal. Bioanal. Chem. , vol.378 , pp. 845-850
    • Hager, J.W.1
  • 10
    • 1642391525 scopus 로고    scopus 로고
    • High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument
    • Hager, J. W., and Le Blanc, J. C. (2003). High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument. J. Chromatogr. A 1020:3-9.
    • (2003) J. Chromatogr. A , vol.1020 , pp. 3-9
    • Hager, J.W.1    Le Blanc, J.C.2
  • 11
    • 0038409059 scopus 로고    scopus 로고
    • Product ion scanning using a Q-q-Q linear ion trap (QTR.AP) mass spectrometer
    • Hager, J. W., and Yves Le Blanc, J. C. (2003). Product ion scanning using a Q-q-Q linear ion trap (QTR.AP) mass spectrometer. Rapid Commun. Mass Spectrom. 17:1056-1064.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 1056-1064
    • Hager, J.W.1    Yves Le Blanc, J.C.2
  • 12
    • 52649120591 scopus 로고    scopus 로고
    • Metabolite identification by LC-MS: Applications in drug discovery and development
    • In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury, S. K., Ed.). Elsevier, Amsterdam, The Netherlands
    • Hop, C. E. C. A., and Prakash, C. (2005). Metabolite identification by LC-MS: Applications in drug discovery and development. In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS (Chowdhury, S. K., Ed.). Elsevier, Amsterdam, The Netherlands, pp. 123-158.
    • (2005) , pp. 123-158
    • Hop, C.E.C.A.1    Prakash, C.2
  • 13
    • 0037297379 scopus 로고    scopus 로고
    • Rapid screening and characterization of drug metabolites using a new quadrupole-linear ion trap mass spectrometer
    • Hopfgartner, G., Husser, C., and Zell, M. (2003). Rapid screening and characterization of drug metabolites using a new quadrupole-linear ion trap mass spectrometer. J Mass. Spectrom. 38:138-150.
    • (2003) J Mass. Spectrom. , vol.38 , pp. 138-150
    • Hopfgartner, G.1    Husser, C.2    Zell, M.3
  • 14
    • 4444272971 scopus 로고    scopus 로고
    • Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules
    • Hopfgartner, G., Varesio, E., Tschaeppaet, V., Grivet, C., Bourgogne, E., and Leuthold, L. A. (2004). Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules. J. Mass Spectrom. 39:845-855.
    • (2004) J. Mass Spectrom. , vol.39 , pp. 845-855
    • Hopfgartner, G.1    Varesio, E.2    Tschaeppaet, V.3    Grivet, C.4    Bourgogne, E.5    Leuthold, L.A.6
  • 15
    • 85056512155 scopus 로고    scopus 로고
    • Q Trap MS: A new tool for metabolite identification
    • In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL
    • Hopfgartner, G., and Zell, M. (2005). Q Trap MS: A new tool for metabolite identification. In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, FL, pp. 277-304.
    • (2005) , pp. 277-304
    • Hopfgartner, G.1    Zell, M.2
  • 16
    • 22744441263 scopus 로고    scopus 로고
    • Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument
    • Li, A. C., Alton, D., Bryant, M. S., and Shou,W. Z. (2005). Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument. Rapid Commun. Mass Spectrom. 19:1943-1950.
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 1943-1950
    • Li, A.C.1    Alton, D.2    Bryant, M.S.3    Shou, W.Z.4
  • 17
    • 34247542644 scopus 로고    scopus 로고
    • "N-in-one" strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan
    • Li, A. C., Gohdes, M. A., and Shou, W. Z. (2007). "N-in-one" strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan. Rapid Commun. Mass Spectrom. 21:1421-1430.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 1421-1430
    • Li, A.C.1    Gohdes, M.A.2    Shou, W.Z.3
  • 18
    • 0035983392 scopus 로고    scopus 로고
    • Use of a liquid chromatography/ion trap mass spectrometry/triple quadrupole mass spectrometry system for metabolite identification
    • Liu, D. Q., Xia, Y. Q., and Bakhtiar, R. (2002). Use of a liquid chromatography/ion trap mass spectrometry/triple quadrupole mass spectrometry system for metabolite identification. Rapid Commun. Mass Spectrom. 16:1330-1336.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 1330-1336
    • Liu, D.Q.1    Xia, Y.Q.2    Bakhtiar, R.3
  • 19
    • 33745758232 scopus 로고    scopus 로고
    • Application of mass spectrometry for metabolite identification
    • Ma, S., Chowdhury, S. K., and Alton, K. B. (2006). Application of mass spectrometry for metabolite identification. Curr. Drug Metab. 7:503-523.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 503-523
    • Ma, S.1    Chowdhury, S.K.2    Alton, K.B.3
  • 20
    • 0030999705 scopus 로고    scopus 로고
    • An introduction to quadrupole ion trap mass spectrometery
    • March, R. E. (1997). An introduction to quadrupole ion trap mass spectrometery. J. Mass Spectrom. 32:351-369.
    • (1997) J. Mass Spectrom. , vol.32 , pp. 351-369
    • March, R.E.1
  • 21
    • 0031765003 scopus 로고    scopus 로고
    • Quadrupole ion trap mass spectrometry: Theory, simulation, recent development and applications
    • March, R. E. (1998). Quadrupole ion trap mass spectrometry: Theory, simulation, recent development and applications. Rapid Commun. Mass Spectom. 12:1543-1554.
    • (1998) Rapid Commun. Mass Spectom. , vol.12 , pp. 1543-1554
    • March, R.E.1
  • 22
    • 0037642865 scopus 로고    scopus 로고
    • Quadrupole ion trap mass spectrometer
    • In Encyclopedia of Analytical Chemistry (Meyers, R. A., Ed.). Wiley, Chichester
    • March, R. E. (2000a). Quadrupole ion trap mass spectrometer. In Encyclopedia of Analytical Chemistry (Meyers, R. A., Ed.). Wiley, Chichester, pp. 11848-11872.
    • (2000) , pp. 11848-11872
    • March, R.E.1
  • 23
    • 0034716129 scopus 로고    scopus 로고
    • Quadrupole ion trap mass spectrometry. A view at the turn of the century
    • March, R. E. (2000b). Quadrupole ion trap mass spectrometry. A view at the turn of the century. Int. J. Mass Spectrom. 200:285-312.
    • (2000) Int. J. Mass Spectrom. , vol.200 , pp. 285-312
    • March, R.E.1
  • 24
    • 0025250367 scopus 로고
    • Aspects of recent developments in ion-trap mass spectrometry
    • Nourse, B. D., and Cooks, R. G. (1990). Aspects of recent developments in ion-trap mass spectrometry. Anal. Chim. Acta 228:1-21.
    • (1990) Anal. Chim. Acta , vol.228 , pp. 1-21
    • Nourse, B.D.1    Cooks, R.G.2
  • 25
    • 2442694251 scopus 로고    scopus 로고
    • Integration of custom LC/MS automated data processing strategies for the rapid assessment of metabolic stability and metabolite identification in drug discovery
    • In Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL
    • Rourick, R. A., Jenkins, K. M., Walsh, J. P., Xu, R., Cai, Z., and Kassel, D. B. (2002). Integration of custom LC/MS automated data processing strategies for the rapid assessment of metabolic stability and metabolite identification in drug discovery. In Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL.
    • (2002)
    • Rourick, R.A.1    Jenkins, K.M.2    Walsh, J.P.3    Xu, R.4    Cai, Z.5    Kassel, D.B.6
  • 26
  • 27
    • 0038497484 scopus 로고    scopus 로고
    • Ion trap mass spectrometry: A personal perspective
    • Stafford, G. (2002). Ion trap mass spectrometry: A personal perspective. J. Am. Soc. Mass Spectrom. 13:589-596.
    • (2002) J. Am. Soc. Mass Spectrom. , vol.13 , pp. 589-596
    • Stafford, G.1
  • 28
    • 0031659688 scopus 로고    scopus 로고
    • A new scan mode for the identification of multiply charged ions
    • Thomson, B. A., and Chernushevich, I. V. (1998). A new scan mode for the identification of multiply charged ions. Rapid Commun. Mass Spectrom. 12:1323-1229.
    • (1998) Rapid Commun. Mass Spectrom. , vol.12 , pp. 1323-1229
    • Thomson, B.A.1    Chernushevich, I.V.2
  • 29
    • 0038361179 scopus 로고    scopus 로고
    • Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis
    • Xia, Y. Q., Miller, J. D., Bakhtiar, R., Franklin, R. B., and Liu, D. Q. (2003). Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis. Rapid Commun. Mass Spectrom. 17:1137-1145.
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 1137-1145
    • Xia, Y.Q.1    Miller, J.D.2    Bakhtiar, R.3    Franklin, R.B.4    Liu, D.Q.5
  • 30
    • 33947093279 scopus 로고
    • Selected ion fragmentation with a tandem quadrupole mass spectrometer
    • Yost, R. A., and Enke, C. G. (1978). Selected ion fragmentation with a tandem quadrupole mass spectrometer. J. Am. Chem. Soc. 100:2274-2275.
    • (1978) J. Am. Chem. Soc. , vol.100 , pp. 2274-2275
    • Yost, R.A.1    Enke, C.G.2
  • 31
    • 0001366599 scopus 로고
    • Triple quadrupole mass spectrometry for direct mixture analysis and structure elucidation
    • Yost, R. A., and Enke, C. G. (1979). Triple quadrupole mass spectrometry for direct mixture analysis and structure elucidation. Anal. Chem. 51:1251A-1264A.
    • (1979) Anal. Chem. , vol.51
    • Yost, R.A.1    Enke, C.G.2
  • 32
    • 24644485387 scopus 로고    scopus 로고
    • Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies:Application to structure elucidation of buspirone and one of its metabolites
    • Zhang, M. Y., Pace, N., Kerns, E. H., Kleintop, T., Kagan, N., and Sakuma, T. (2005). Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies:Application to structure elucidation of buspirone and one of its metabolites. J. Mass. Spectrom. 40:1017-1029.
    • (2005) J. Mass. Spectrom. , vol.40 , pp. 1017-1029
    • Zhang, M.Y.1    Pace, N.2    Kerns, E.H.3    Kleintop, T.4    Kagan, N.5    Sakuma, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.