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Volumn 6, Issue , 2012, Pages 251-259

Cholesteryl ester transfer protein inhibitors for dyslipidemia: Focus on dalcetrapib

Author keywords

Cardiovascular disease; CETP inhibitor; Dalcetrapib; HDL

Indexed keywords

ANACETRAPIB; APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; DALCETRAPIB; EVACETRAPIB; EZETIMIBE; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETOCONAZOLE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; PLACEBO; TORCETRAPIB; TRIACYLGLYCEROL;

EID: 84872320164     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S34976     Document Type: Review
Times cited : (17)

References (67)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C, Keech A, Kearney P, Al E. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005;366(9493):1267-1278.
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.3    Al, E.4
  • 2
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. The Framingham study
    • Gordon T, Castelli W P, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham study. Am J Med. 1977;62(5):707-714.
    • (1977) Am J Med , vol.62 , Issue.5 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3    Kannel, W.B.4    Dawber, T.R.5
  • 3
    • 0024501678 scopus 로고
    • High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies
    • Gordon DJ, Probstfeld JL, Garrison RJ, et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 1989;79(1):8-15.
    • (1989) Circulation , vol.79 , Issue.1 , pp. 8-15
    • Gordon, D.J.1    Probstfeld, J.L.2    Garrison, R.J.3
  • 4
    • 38849140840 scopus 로고    scopus 로고
    • Is raising HDL a futile strategy for atheroprotection?
    • Joy T, Hegele RA. Is raising HDL a futile strategy for atheroprotection? Nat Rev Drug Discov. 2008;7(2):143-155.
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.2 , pp. 143-155
    • Joy, T.1    Hegele, R.A.2
  • 5
    • 0033670164 scopus 로고    scopus 로고
    • Distribution of ApoA-I- containing HDL subpopulations in patients with coronary heart disease
    • Asztalos B F, Roheim PS, Milani RL, et al. Distribution of ApoA-I- containing HDL subpopulations in patients with coronary heart disease. Arterioscler Thromb Vasc Biol. 2000;20(12):2670-2676.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , Issue.12 , pp. 2670-2676
    • Asztalos, B.F.1    Roheim, P.S.2    Milani, R.L.3
  • 7
    • 60549091035 scopus 로고    scopus 로고
    • High-density lipoproteins, infammation and oxidative stress
    • Tabet F, Rye K-A. High-density lipoproteins, infammation and oxidative stress. Clin Sci. 2009;116(2):87-98.
    • (2009) Clin Sci , vol.116 , Issue.2 , pp. 87-98
    • Tabet, F.1    Rye, K.-A.2
  • 8
    • 84857273957 scopus 로고    scopus 로고
    • On- and off- target pharmacology of torcetrapib: Current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors
    • Johns DG, Duffy J, Fisher T, Hubbard BK, Forrest MJ. On- and off- target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors. Drugs. 2012;72(4):491-507.
    • (2012) Drugs , vol.72 , Issue.4 , pp. 491-507
    • Johns, D.G.1    Duffy, J.2    Fisher, T.3    Hubbard, B.K.4    Forrest, M.J.5
  • 9
    • 33646409606 scopus 로고    scopus 로고
    • HDL from CETP-defcient subjects shows enhanced ability to promote cholesterol effux from macrophages in an apoE- and ABCG1-dependent pathway
    • Matsuura F. HDL from CETP-defcient subjects shows enhanced ability to promote cholesterol effux from macrophages in an apoE- and ABCG1-dependent pathway. J Clin Invest. 2006;116(5):1435-1442.
    • (2006) J Clin Invest , vol.116 , Issue.5 , pp. 1435-1442
    • Matsuura, F.1
  • 10
    • 36849023953 scopus 로고    scopus 로고
    • Relation of gemfbrozil treatment and high-density lipoprotein subpopulation profle with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    • Asztalos BF, Collins D, Horvath K V, Bloomfeld HE, Robins SJ, Schaefer EJ. Relation of gemfbrozil treatment and high-density lipoprotein subpopulation profle with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Metab Clin Exp. 2008;57(1):77-83.
    • (2008) Metab Clin Exp , vol.57 , Issue.1 , pp. 77-83
    • Asztalos, B.F.1    Collins, D.2    Horvath, K.V.3    Bloomfeld, H.E.4    Robins, S.J.5    Schaefer, E.J.6
  • 11
    • 0020034696 scopus 로고
    • High density and low density lipoprotein subfractions in survivors of myocardial infarction and in control subjects
    • Ballantyne FC, Clark RS, Simpson HS, Ballantyne D. High density and low density lipoprotein subfractions in survivors of myocardial infarction and in control subjects. Metab Clin Exp. 1982;31(5):433-437.
    • (1982) Metab Clin Exp , vol.31 , Issue.5 , pp. 433-437
    • Ballantyne, F.C.1    Clark, R.S.2    Simpson, H.S.3    Ballantyne, D.4
  • 12
    • 0345396377 scopus 로고
    • Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia
    • Patsch JR, Karlin JB, Scott LW, Smith LC, Gotto AM. Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia. Proc Natl Acad Sci U S A. 1983;80(5):1449-1453.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , Issue.5 , pp. 1449-1453
    • Patsch, J.R.1    Karlin, J.B.2    Scott, L.W.3    Smith, L.C.4    Gotto, A.M.5
  • 13
    • 84872295286 scopus 로고    scopus 로고
    • CETP Inhibitors: Will they live up to their promise?
    • Cheung V, Hegele RA. CETP Inhibitors: will they live up to their promise? Curr Cardiovasc Risk Rep. 2011;6(1):4-11.
    • (2011) Curr Cardiovasc Risk Rep , vol.6 , Issue.1 , pp. 4-11
    • Cheung, V.1    Hegele, R.A.2
  • 14
    • 26244436291 scopus 로고    scopus 로고
    • Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    • Asztalos B F, Collins D, Cupples LA, et al. Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial. Arterioscler Thromb Vasc Biol. 2005;25(10):2185-2191.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , Issue.10 , pp. 2185-2191
    • Asztalos, B.F.1    Collins, D.2    Cupples, L.A.3
  • 15
    • 8344241096 scopus 로고    scopus 로고
    • High-density lipoprotein subpopulation profle and coronary heart disease prevalence in male participants of the Framingham Offspring Study
    • Asztalos BF, Cupples LA, Demissie S, et al. High-density lipoprotein subpopulation profle and coronary heart disease prevalence in male participants of the Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 2004;24(11):2181-2187.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , Issue.11 , pp. 2181-2187
    • Asztalos, B.F.1    Cupples, L.A.2    Demissie, S.3
  • 16
    • 78651379500 scopus 로고    scopus 로고
    • Cholesterol effux capacity, high-density lipoprotein function, and atherosclerosis
    • Khera AV, Cuchel M, la Llera-Moya M de, et al. Cholesterol effux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. 2011;364(2):127-135.
    • (2011) N Engl J Med , vol.364 , Issue.2 , pp. 127-135
    • Khera, A.V.1    Cuchel, M.2    la Llera-Moya, M.3
  • 17
    • 84858188571 scopus 로고    scopus 로고
    • Dalcetrapib - restoring belief in modulating CETP as a benefcial mechanism in cardiovascular disease
    • Doggrell SA. Dalcetrapib - restoring belief in modulating CETP as a benefcial mechanism in cardiovascular disease. Expert Opin Investig Drugs. 2012;21(4):569-573.
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.4 , pp. 569-573
    • Doggrell, S.A.1
  • 18
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • AIM-HIGH Investigators, Boden WE, Probstfeld JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24):2255-2267.
    • (2011) N Engl J Med , vol.365 , Issue.24 , pp. 2255-2267
    • Boden, W.E.1    Probstfeld, J.L.2
  • 19
    • 80053163075 scopus 로고    scopus 로고
    • Anacetrapib: Hope for CETP inhibitors?
    • Gurfinkel R, Joy TR. Anacetrapib: hope for CETP inhibitors? Cardiovasc Ther. 2011;29(5):327-339.
    • (2011) Cardiovasc Ther , vol.29 , Issue.5 , pp. 327-339
    • Gurfinkel, R.1    Joy, T.R.2
  • 20
    • 84872315308 scopus 로고    scopus 로고
    • HPS2-THRIVE [webpage on the Internet], [updated June 14, 2012], Accessed June 18, 2011
    • HPS2-THRIVE [webpage on the Internet]. Oxford: Clinical Trial Service Unit [updated June 14, 2012]. Available from: http://www.ctsu.ox.ac.uk/~thrive/. Accessed June 18, 2011.
    • Oxford: Clinical Trial Service Unit
  • 21
    • 79960648677 scopus 로고    scopus 로고
    • Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism
    • Niesor EJ. Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism. Curr Opin Lipidol. 2011;22(4):288-295.
    • (2011) Curr Opin Lipidol , vol.22 , Issue.4 , pp. 288-295
    • Niesor, E.J.1
  • 22
    • 33845320131 scopus 로고    scopus 로고
    • Molecular regulation of HDL metabolism and function: Implications for novel therapies
    • Rader DJ. Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest. 2006;116(12):3090-3100.
    • (2006) J Clin Invest , vol.116 , Issue.12 , pp. 3090-3100
    • Rader, D.J.1
  • 23
    • 34447266483 scopus 로고    scopus 로고
    • Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits
    • Morehouse LA, Sugarman ED, Bourassa PA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits. J Lipid Res. 2007;48(6): 1263-1272.
    • (2007) J Lipid Res , vol.48 , Issue.6 , pp. 1263-1272
    • Morehouse, L.A.1    Sugarman, E.D.2    Bourassa, P.A.3
  • 24
    • 12144287356 scopus 로고    scopus 로고
    • Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: An initial multidose study of torcetrapib
    • Clark RW, Sutfn TA, Ruggeri RB, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004;24(3):490-497.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , Issue.3 , pp. 490-497
    • Clark, R.W.1    Sutfn, T.A.2    Ruggeri, R.B.3
  • 25
    • 33750447972 scopus 로고    scopus 로고
    • Effcacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoproteincholesterol levels on a background of at orvastatin
    • McKenney JM, Davidson MH, Shear CL, Revkin JH. Effcacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoproteincholesterol levels on a background of at orvastatin. J Am Coll Cardiol. 2006;48(9):1782-1790.
    • (2006) J Am Coll Cardiol , vol.48 , Issue.9 , pp. 1782-1790
    • McKenney, J.M.1    Davidson, M.H.2    Shear, C.L.3    Revkin, J.H.4
  • 26
    • 33846424247 scopus 로고    scopus 로고
    • The failure of torcetrapib: Was it the molecule or the mechanism?
    • Tall AR, Yvan-Charvet L, Wang N. The failure of torcetrapib: was it the molecule or the mechanism? Arterioscler Thromb Vasc Biol. 2007;27(2):257-260.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.2 , pp. 257-260
    • Tall, A.R.1    Yvan-Charvet, L.2    Wang, N.3
  • 27
    • 79952124251 scopus 로고    scopus 로고
    • Learning lessons from Pfzer's $800 million failure
    • Mullard A. Learning lessons from Pfzer's $800 million failure. Nat Rev Drug Discov. 2011;10(3):163-164.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.3 , pp. 163-164
    • Mullard, A.1
  • 28
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfeld M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357(21): 2109-2122.
    • (2007) N Engl J Med , vol.357 , Issue.21 , pp. 2109-2122
    • Barter, P.J.1    Caulfeld, M.2    Eriksson, M.3
  • 29
    • 34047106220 scopus 로고    scopus 로고
    • Effect of torcetrapib on the progression of coronary atherosclerosis
    • Nissen SE, Tardif J-C, Nicholls SJ, et al. Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med. 2007;356(13): 1304-1316.
    • (2007) N Engl J Med , vol.356 , Issue.13 , pp. 1304-1316
    • Nissen, S.E.1    Tardif, J.-C.2    Nicholls, S.J.3
  • 30
    • 34247241088 scopus 로고    scopus 로고
    • Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    • Kastelein JJP, van Leuven SI, Burgess L, et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med. 2007;356(16):1620-1630.
    • (2007) N Engl J Med , vol.356 , Issue.16 , pp. 1620-1630
    • Kastelein, J.J.P.1    van Leuven, S.I.2    Burgess, L.3
  • 31
    • 34447265547 scopus 로고    scopus 로고
    • Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): A randomised, double-blind trial
    • Bots ML, Visseren FL, Evans G W, et al. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. Lancet. 2007;370(9582): 153-160.
    • (2007) Lancet , vol.370 , Issue.9582 , pp. 153-160
    • Bots, M.L.1    Visseren, F.L.2    Evans, G.W.3
  • 32
    • 58149386896 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: Insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation)
    • Nicholls SJ, Tuzcu EM, Brennan DM, Tardif J-C, Nissen SE. Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). Circulation. 2008;118(24):2506-2514.
    • (2008) Circulation , vol.118 , Issue.24 , pp. 2506-2514
    • Nicholls, S.J.1    Tuzcu, E.M.2    Brennan, D.M.3    Tardif, J.-C.4    Nissen, S.E.5
  • 33
    • 66449084532 scopus 로고    scopus 로고
    • Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition
    • Hu X, Dietz JD, Xia C, et al. Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009;150(5):2211-2219.
    • (2009) Endocrinology , vol.150 , Issue.5 , pp. 2211-2219
    • Hu, X.1    Dietz, J.D.2    Xia, C.3
  • 34
    • 48149106322 scopus 로고    scopus 로고
    • Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    • Forrest MJ, Bloomfeld D, Briscoe RJ, et al. Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br J Pharmacol. 2008;154(7):1465-1473.
    • (2008) Br J Pharmacol , vol.154 , Issue.7 , pp. 1465-1473
    • Forrest, M.J.1    Bloomfeld, D.2    Briscoe, R.J.3
  • 35
    • 78751482905 scopus 로고    scopus 로고
    • Anacetrapib and dalcetrapib: Two novel cholesteryl ester transfer protein inhibitors
    • Miyares MA. Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors. Ann Pharmacother. 2011;45(1):84-94.
    • (2011) Ann Pharmacother , vol.45 , Issue.1 , pp. 84-94
    • Miyares, M.A.1
  • 36
    • 78549235583 scopus 로고    scopus 로고
    • Safety of anacetrapib in patients with or at high risk for coronary heart disease
    • Cannon C P, Shah S, Dansky HM, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Engl J Med. 2010;363(25):2406-2415.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2406-2415
    • Cannon, C.P.1    Shah, S.2    Dansky, H.M.3
  • 37
    • 58649091088 scopus 로고    scopus 로고
    • Effcacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients
    • e2
    • Bloomfeld D, Carlson GL, Sapre A, et al. Effcacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients. Am Heart J. 2009;157(2):352-360. e2.
    • (2009) Am Heart J , vol.157 , pp. 352-360
    • Bloomfeld, D.1    Carlson, G.L.2    Sapre, A.3
  • 38
    • 65349191226 scopus 로고    scopus 로고
    • Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects
    • Krishna R, Garg A, Jin B, et al. Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Br J Clin Pharmacol. 2009;67(5):520-526.
    • (2009) Br J Clin Pharmacol , vol.67 , Issue.5 , pp. 520-526
    • Krishna, R.1    Garg, A.2    Jin, B.3
  • 39
    • 36549078679 scopus 로고    scopus 로고
    • Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: Two double-blind, randomised placebo-controlled phase I studies
    • Krishna R, Anderson MS, Bergman AJ, et al. Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies. Lancet. 2007;370(9603):1907-1914.
    • (2007) Lancet , vol.370 , Issue.9603 , pp. 1907-1914
    • Krishna, R.1    Anderson, M.S.2    Bergman, A.J.3
  • 40
    • 56549117314 scopus 로고    scopus 로고
    • Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects
    • Krishna R, Bergman AJ, Jin B, et al. Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Clin Pharmacol Ther. 2008;84(6):679-683.
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.6 , pp. 679-683
    • Krishna, R.1    Bergman, A.J.2    Jin, B.3
  • 41
    • 57849131140 scopus 로고    scopus 로고
    • Cholesterylestertransfer protein inhibition and endothelial function in type II hyperlipidemia
    • Hermann F, Enseleit F, Spieker LE, et al. Cholesterylestertransfer protein inhibition and endothelial function in type II hyperlipidemia. Thromb Res. 2009;123(3):460-465.
    • (2009) Thromb Res , vol.123 , Issue.3 , pp. 460-465
    • Hermann, F.1    Enseleit, F.2    Spieker, L.E.3
  • 42
    • 81255125373 scopus 로고    scopus 로고
    • Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: A randomized controlled trial
    • Nicholls SJ, Brewer HB, Kastelein JJ, et al. Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial. JAMA. 2011;306(19):2099-2109.
    • (2011) JAMA , vol.306 , Issue.19 , pp. 2099-2109
    • Nicholls, S.J.1    Brewer, H.B.2    Kastelein, J.J.3
  • 43
    • 1842815777 scopus 로고    scopus 로고
    • Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    • Brousseau ME, Schaefer EJ, Wolfe ML, et al. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004;350(15):1505-1515.
    • (2004) N Engl J Med , vol.350 , Issue.15 , pp. 1505-1515
    • Brousseau, M.E.1    Schaefer, E.J.2    Wolfe, M.L.3
  • 44
    • 78650054881 scopus 로고    scopus 로고
    • Modulating cholesteryl ester transfer protein activity maintains effcient pre-β-HDL formation and increases reverse cholesterol transport
    • Niesor EJ, Magg C, Ogawa N, et al. Modulating cholesteryl ester transfer protein activity maintains effcient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010;51(12): 3443-3454.
    • (2010) J Lipid Res , vol.51 , Issue.12 , pp. 3443-3454
    • Niesor, E.J.1    Magg, C.2    Ogawa, N.3
  • 45
    • 67649304458 scopus 로고    scopus 로고
    • Safety and tolerability of dalcetrapib
    • Stein EA, Stroes ESG, Steiner G, et al. Safety and tolerability of dalcetrapib. Am J Cardiol. 2009;104(1):82-91.
    • (2009) Am J Cardiol , vol.104 , Issue.1 , pp. 82-91
    • Stein, E.A.1    Stroes, E.S.G.2    Steiner, G.3
  • 46
    • 0036226511 scopus 로고    scopus 로고
    • Effect of HDL, from Japanese white rabbit administered a new cholesteryl ester transfer protein inhibitor JTT-705, on cholesteryl ester accumulation induced by acetylated low density lipoprotein in J774 macrophage
    • Kobayashi J, Okamoto H, Otabe M, Bujo H, Saito Y. Effect of HDL, from Japanese white rabbit administered a new cholesteryl ester transfer protein inhibitor JTT-705, on cholesteryl ester accumulation induced by acetylated low density lipoprotein in J774 macrophage. Atherosclerosis. 2002;162(1):131-135.
    • (2002) Atherosclerosis , vol.162 , Issue.1 , pp. 131-135
    • Kobayashi, J.1    Okamoto, H.2    Otabe, M.3    Bujo, H.4    Saito, Y.5
  • 47
    • 71249121107 scopus 로고    scopus 로고
    • Dalcetrapib: No off-target toxicity on blood pressure or on genes related to the renin-angio- tensin-aldosterone system in rats
    • Stroes E, Kastelein J, Bénardeau A, et al. Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angio- tensin-aldosterone system in rats. Br J Pharmacol. 2009;158(7): 1763-1770.
    • (2009) Br J Pharmacol , vol.158 , Issue.7 , pp. 1763-1770
    • Stroes, E.1    Kastelein, J.2    Bénardeau, A.3
  • 48
    • 77249100745 scopus 로고    scopus 로고
    • Safety and tolerability of dalcetrapib (RO4607381/JTT-705): Results from a 48-week trial
    • Stein EA, Roth EM, Rhyne JM, Burgess T, Kallend D, Robinson JG. Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial. Eur Heart J. 2010;31(4):480-488.
    • (2010) Eur Heart J , vol.31 , Issue.4 , pp. 480-488
    • Stein, E.A.1    Roth, E.M.2    Rhyne, J.M.3    Burgess, T.4    Kallend, D.5    Robinson, J.G.6
  • 49
    • 77955554815 scopus 로고    scopus 로고
    • Lack of effect of dalcetrapib on QT interval in healthy subjects following multiple dosing
    • Derks M, Abt M, Mwangi A, Meneses-Lorente G. Lack of effect of dalcetrapib on QT interval in healthy subjects following multiple dosing. Eur J Clin Pharmacol. 2010;66(8):775-783.
    • (2010) Eur J Clin Pharmacol , vol.66 , Issue.8 , pp. 775-783
    • Derks, M.1    Abt, M.2    Mwangi, A.3    Meneses-Lorente, G.4
  • 50
    • 79953822473 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of dalcetrapib following single and multiple ascending doses in healthy subjects: A randomized, double-blind, placebo-controlled
    • Derks M, Anzures-Cabrera J, Turnbull L, Phelan M. Safety, tolerability and pharmacokinetics of dalcetrapib following single and multiple ascending doses in healthy subjects: a randomized, double-blind, placebo-controlled, Phase I study. 2011;31(5):325-335.
    • (2011) Phase I Study , vol.31 , Issue.5 , pp. 325-335
    • Derks, M.1    Anzures-Cabrera, J.2    Turnbull, L.3    Phelan, M.4
  • 51
    • 77956565180 scopus 로고    scopus 로고
    • Coadministration of dalcetrapib with pravastatin, rosuvastatin, or simvastatin: No clinically relevant drug-drug interactions
    • Derks M, Abt M, Phelan M, et al. Coadministration of dalcetrapib with pravastatin, rosuvastatin, or simvastatin: no clinically relevant drug-drug interactions. J Clin Pharmacol. 2010;50(10):1188-1201.
    • (2010) J Clin Pharmacol , vol.50 , Issue.10 , pp. 1188-1201
    • Derks, M.1    Abt, M.2    Phelan, M.3
  • 52
    • 78349291598 scopus 로고    scopus 로고
    • Lack of clinically relevant drug-drug interactions when dalcetrapib is co-administered with ezetimibe
    • Derks M, Abt M, Phelan M. Lack of clinically relevant drug-drug interactions when dalcetrapib is co-administered with ezetimibe. Br J Clin Pharmacol. 2010;70(6):825-833.
    • (2010) Br J Clin Pharmacol , vol.70 , Issue.6 , pp. 825-833
    • Derks, M.1    Abt, M.2    Phelan, M.3
  • 53
    • 64849084213 scopus 로고    scopus 로고
    • A single-center, open-label, one- sequence study of dalcetrapib coadministered with ketoconazole, and an in vitro study of the S-methyl metabolite of dalcetrapib
    • Derks M, Fowler S, Kuhlmann O. A single-center, open-label, one- sequence study of dalcetrapib coadministered with ketoconazole, and an in vitro study of the S-methyl metabolite of dalcetrapib. Clin Ther. 2009;31(3):586-599.
    • (2009) Clin Ther , vol.31 , Issue.3 , pp. 586-599
    • Derks, M.1    Fowler, S.2    Kuhlmann, O.3
  • 54
    • 0037035459 scopus 로고    scopus 로고
    • Effcacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomized phase II dose-response study
    • de Grooth GJ, Kuivenhoven JA, Stalenhoef AF, et al. Effcacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study. Circulation. 2002;105(18):2159-2165.
    • (2002) Circulation , vol.105 , Issue.18 , pp. 2159-2165
    • de Grooth, G.J.1    Kuivenhoven, J.A.2    Stalenhoef, A.F.3
  • 55
    • 17444372760 scopus 로고    scopus 로고
    • Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
    • Kuivenhoven JA, de Grooth GJ, Kawamura H, et al. Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia. Am J Cardiol. 2005;95(9):1085-1088.
    • (2005) Am J Cardiol , vol.95 , Issue.9 , pp. 1085-1088
    • Kuivenhoven, J.A.1    de Grooth, G.J.2    Kawamura, H.3
  • 56
    • 80255122648 scopus 로고    scopus 로고
    • Safety and effcacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): A randomised clinical trial
    • Fayad ZA, Mani V, Woodward M, et al. Safety and effcacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial. Lancet. 2011; 378(9802):1547-1559.
    • (2011) Lancet , vol.378 , Issue.9802 , pp. 1547-1559
    • Fayad, Z.A.1    Mani, V.2    Woodward, M.3
  • 57
    • 84859517252 scopus 로고    scopus 로고
    • Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: The dal-VES- SEL randomized clinical trial
    • Luscher T F, Taddei S, Kaski JC, et al. Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VES- SEL randomized clinical trial. Eur Heart J. 2012;33(7):857-865.
    • (2012) Eur Heart J , vol.33 , Issue.7 , pp. 857-865
    • Luscher, T.F.1    Taddei, S.2    Kaski, J.C.3
  • 58
    • 84870496111 scopus 로고    scopus 로고
    • ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated August 15, 2012], Accessed September 9, 2012
    • Roche. A study of the effect of dalcetrapib on artherosclerotic disease in patients with coronary artery disease. In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated August 15, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01059682.NLM identifer: NCT01059682. Accessed September 9, 2012.
    • A Study of the Effect of Dalcetrapib On Artherosclerotic Disease In Patients With Coronary Artery Disease
    • Roche1
  • 59
    • 84872342133 scopus 로고    scopus 로고
    • ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated July 5, 2012], Accessed September 3, 2012
    • Roche. A study of dalcetrapib in patients hospitalized for an acute coronary syndrome (Dal-ACUTE) In: ClinicalTrials.gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated July 5, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01323153.NLM identifer: NCT01323153. Accessed September 3, 2012.
    • A Study of Dalcetrapib In Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)
    • Roche1
  • 60
    • 70749131522 scopus 로고    scopus 로고
    • Rationale and design of the dal-OUTCOMES trial: Effcacy and safety of dalcetrapib in patients with recent acute coronary syndrome
    • e3
    • Schwartz GG, Olsson AG, Ballantyne CM, et al. Rationale and design of the dal-OUTCOMES trial: effcacy and safety of dalcetrapib in patients with recent acute coronary syndrome. Am Heart J. 2009;158(6): 896-901. e3.
    • (2009) Am Heart J , vol.158 , Issue.6 , pp. 896-901
    • Schwartz, G.G.1    Olsson, A.G.2    Ballantyne, C.M.3
  • 61
    • 77952410983 scopus 로고    scopus 로고
    • Dalcetrapib: A review of Phase II data
    • Robinson JG. Dalcetrapib: a review of Phase II data. Expert Opin Investig Drugs. 2010;19(6):795-805.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.6 , pp. 795-805
    • Robinson, J.G.1
  • 62
    • 84872354769 scopus 로고    scopus 로고
    • F Hoffmann-La Roche Ltd, Basel: F Hoffmann-La Roche Ltd; 2012 [May 7], Accessed. June 11, 2012
    • F Hoffmann-La Roche Ltd. Roche provides update on Phase III study of dalcetrapib [media release]. Basel: F Hoffmann-La Roche Ltd; 2012 [May 7]. Available from: http://www.roche.com/media/media_releases/ med-cor-2012-05-07.htm. Accessed. June 11, 2012.
    • Roche Provides Update On Phase III Study of Dalcetrapib [media Release]
  • 63
    • 84871311530 scopus 로고    scopus 로고
    • Montreal: theheart.org, Accessed May 30, 2012
    • Miller R. Roche stops dalcetrapib trial for lack of beneft. Montreal: theheart.org; 2012. Available from: http://www.theheart.org/arti-cle/1395141.do. Accessed May 30, 2012.
    • (2012) Roche Stops Dalcetrapib Trial For Lack of Beneft
    • Miller, R.1
  • 64
    • 45349105911 scopus 로고    scopus 로고
    • Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk
    • Thompson A, Di Angelantonio E, Sarwar N, et al. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA. 2008;299(23):2777-2788.
    • (2008) JAMA , vol.299 , Issue.23 , pp. 2777-2788
    • Thompson, A.1    Di Angelantonio, E.2    Sarwar, N.3
  • 65
    • 84864845456 scopus 로고    scopus 로고
    • Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
    • Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380(9841):572-580.
    • (2012) Lancet , vol.380 , Issue.9841 , pp. 572-580
    • Voight, B.F.1    Peloso, G.M.2    Orho-Melander, M.3
  • 66
    • 84861100469 scopus 로고    scopus 로고
    • Evacetrapib
    • Nicholls SJ. Evacetrapib. Curr Cardiol Rep. 2012;14(3):245-250.
    • (2012) Curr Cardiol Rep , vol.14 , Issue.3 , pp. 245-250
    • Nicholls, S.J.1
  • 67
    • 84863815186 scopus 로고    scopus 로고
    • Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) Inhibitors
    • Harikrishnan LS, Finlay HJ, Qiao JX, et al. Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) Inhibitors. J Med Chem. 2012;55(13):6162-6175.
    • (2012) J Med Chem , vol.55 , Issue.13 , pp. 6162-6175
    • Harikrishnan, L.S.1    Finlay, H.J.2    Qiao, J.X.3


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