Characterization of a novel α-conotoxin from Conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors

Journal of Biological Chemistry

Volumn 288, Issue 2, 2013, Pages 894-902

  Luo, Sulan ^a   Zhangsun, Dongting ^a   Wu, Yong ^a   Zhu, Xiaopeng ^a   Hu, Yuanyan ^a   McIntyre, Melissa ^b   Christensen, Sean ^b   Akcan, Muharrem ^c   Craik, David J ^c   McIntosh, J Michael ^b  

^a HAINAN UNIVERSITY   (China)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CONOTOXINS; DOPAMINERGIC NEURONS; GENE CLONING; NICOTINE ADDICTION; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); PARKINSON DISEASE; SELECTIVE LIGANDS; THERAPEUTIC TARGETS; THREE-DIMENSIONAL SOLUTIONS; XENOPUS LAEVIS OOCYTES;

AMIDES; AMINO ACIDS; DISEASES; NEURONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES;

TEXTILES;

ALPHA CONOTOXIN; CONOTOXIN; GLYCINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA2BETA3; NICOTINIC RECEPTOR ALPHA6; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SYNTHESIS; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CONUS TEXTILE; IC 50; MOLECULAR CLONING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RAT; SNAIL; XENOPUS LAEVIS;

ANIMALS; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CONOTOXINS; CONUS SNAIL; DNA PRIMERS; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; POLYMERASE CHAIN REACTION; RECEPTORS, NICOTINIC;

CONUS TEXTILE; RATTUS; XENOPUS LAEVIS;

EID: 84872317972     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.427898     Document Type: Article

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