An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model

Clinical and Experimental Immunology

Volumn 116, Issue 1, 1999, Pages 107-114

  Williamson, E Diane ^a   Vesey, P M ^a   Gillhespy, K J ^a   Eley, S M ^a   Green, M ^a   Titball, R W ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Immunological correlates; Plague; Protection; Sub unit vaccine

Indexed keywords

BACTERIAL ANTIGEN; IMMUNOGLOBULIN G1; PLAGUE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; PLAGUE; PRIORITY JOURNAL; YERSINIA PESTIS;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CAUSALITY; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG SYNERGISM; FEMALE; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; PLAGUE; PLAGUE VACCINE; PORE FORMING CYTOTOXIC PROTEINS; VACCINES, SYNTHETIC;

EID: 0032901728     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00859.x     Document Type: Article

References (17)

1. 1 Perry RD, Fetherston JD. Yersinia pestis-etiologic agent of plague. Clin Microbiol Rev 1997; 10:35-66.
2. 2 Marshall JD, Bartelloni PJ, Cavanaugh DC, Kadull PJ, Meyer KF. Plague immunisation. II. Relation of adverse clinical reactions to multiple immunisations with killed vaccine. J Infect Dis 1974; 129:S19-s25.
3. 3 Meyer KF. Effectiveness of live or killed plague vaccines in man. Bull WHO 1970; 42:653-66.
4. 4 Williamson ED, Eley SM, Stagg AJ, Green M, Russell P, Titball RW. A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunised animals against pneumonic plague. Vaccine 1997; 15:1079-84.
5. 5 Williamson ED, Eley SM, Griffin KF et al. A new improved sub-unit vaccine for plague: the basis of protection. FEMS Immunol Med Microbiol 1995; 12:223-30.
6. 6 Andrews GP, Heath DG, Anderson GW, Welkos SL, Friedlander AM. Fraction 1 capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge. Infect Immun 1996; 64:2180-7.
7. 7 Anderson GW, Leary SEC, Williamson ED, Titball RW, Welkos SL, Worsham PL, Friedlander AM. Recombinant V antigen protects mice against pneumonic and bubonic plague against F1 capsule positive and negative strains of Y. pestis. Infect Immun 1996; 64:4580-5.
8. 8 Leary SEC, Williamson ED, Griffin KF, Russell P, Eley SM, Titball RW. Active immunisation with recombinant V antigen from Yersinia pestis protects mice against plague. Infect Immun 1995; 63:2854-8.
9. 9 Anderson GW, Heath DG, Bolt CR, Welkos SL, Friedlander AM. Short and long term efficacy of single dose sub-unit vaccines against Yersinia pestis in mice. Am J Hyg Trop Med; 1998; 58:793-9.
10. 10 Green M, Rogers D, Russell P, Stagg AJ, Bell DL, Eley SM, Titball RW, Williamson ED. The SCID/Beige mouse as a model to investigate protection against Yersinia pestis. FEMS Immunol Med Microbiol; 1999; 23:107-13.
11. 11 Titball RW, Howells AM, Oyston PCF, Williamson ED. Expression of the Yersinia pestis capsular antigen (F1 antigen) on the surface of an aroA mutant of Salmonella typhimurium induces high levels of protection against plague. Infect Immun 1997; 65:1926-30.
12. 12 Williamson ED, Sharpe GJE, Eley SM, Vesey PM, Pepper TC, Titball RW, Alpar HO. Local and systemic immune response to a microencapsulated sub-unit vaccine for plague. Vaccine. 1996; 14:1613-9.
13. 13 Russell P, Eley SM, Hibbs SE, Manchee RJ, Stagg AJ, Titball RW. A comparison of Plague Vaccine USP and ev76 vaccine induced protection against Yersinia pestis in a murine model. Vaccine 1995; 13:1551-6.
14. 14 Leonard JM. In: The arithmetic of decision-making. London: The English Universities Press Ltd, 1971.
15. 15 Finney DJ. In: Probit analysis, 3rd edn. Cambridge: Cambridge University Press, 1971:34.
16. 16 Snapper CM, Finkelman FD, Paul WE. Differential regulation of IgG1 and IgE by synthesis of Interleukin 4. J Exp Med 1988; 167:183-96.
17. 17 Lindblad ER. In: Stewart-Tull DES, ed. The theory and practical application of adjuvants. Chichester: John Wiley and Sons, 1995:21-36