Stress response pathways, toxicity pathways and adverse outcome pathways

Archives of Toxicology

Volumn 87, Issue 1, 2013, Pages 13-14

  Jennings, Paul ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; PROTEIN P53; TRANSCRIPTION FACTOR NRF2;

APOPTOSIS; CANCER CELL; CARCINOGENESIS; CELL AGING; CELL CYCLE ARREST; CELL HYPOXIA; CELL PROLIFERATION; CELL STRESS; CELL TYPE; CELLULAR STRESS RESPONSE; CYTOTOXICITY; DNA DAMAGE; ECOTOXICITY; EDITORIAL; GENE ACTIVATION; GENETIC TRANSCRIPTION; GENOTOXICITY; HEMOSTASIS; HUMAN; MOLECULAR BIOLOGY; MOLECULAR GENETICS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

GENE EXPRESSION REGULATION; HUMANS; XENOBIOTICS;

EID: 84872305587     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0974-4     Document Type: Editorial

References (8)

1. Ankley GT, Bennett RS, Erickson RJ et al (2010) Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem SETAC 29(3):730-741. doi:10.1002/etc.34
2. Crunkhorn S (2012) Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress. Nat Rev Drug Discov 11(2):96. doi:10.1038/nrd3655
3. Enomoto A, Itoh K, Nagayoshi E et al (2001) High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci Off J Soc Toxicol 59(1):169-177
4. Jennings P, Limonciel A, Felice L, Leonard MO (2012) An overview of transcriptional regulation in response to toxicological insult. Arch Toxicol. doi:10.1007/s00204-012-0919-y
5. Krewski D, Acosta D Jr., Andersen M et al (2010) Toxicity testing in the 21st century: A vision and a strategy. J Toxicol Environ Health Part B Crit Rev 13(2-4):51-138. doi:10.1080/10937404. 2010.483176
6. NRC (2007) Toxicity testing in the 21st century: A vision and a strategy. The National Academies Press, Washington. http://www.nap.edu/openbook.php? record-id=11970
7. Sporn MB, Liby KT (2012) NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer 12(8):564-571. doi: 10.1038/nrc3278
8. Stegh AH (2012) Targeting the p53 signaling pathway in cancer therapy -the promises, challenges and perils. Expert Opin Ther Targets 16(1):67-83. doi:10.1517/14728222.2011.643299