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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 907-911

Novel benzoxazole inhibitors of mPGES-1

(9) Kablaoui, Natasha a Patel, Snahel b Shao, Jay a Demian, Douglas c Hoffmaster, Keith d Berlioz, Francioise e Vazquez, Michael L a Moore, William M f Nugent, Richard A a

a PFIZER INC (United States)

b GENENTECH INC (United States)

c Blue Sky Biotech Inc (United States)

d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

e VERTEX PHARMACEUTICALS (United States)

f MONSANTO COMPANY (United States)

Author keywords

Benzoxazole; mPGES 1; Selective

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; BENZOXAZOLE DERIVATIVE; CYCLOOXYGENASE 2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG HALF LIFE; ENZYME ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; IC 50; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMIDES; ANIMALS; BENZOXAZOLES; BIOLOGICAL AVAILABILITY; DOGS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS;

EID: 84872305278 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.10.040 Document Type: Article

Times cited : (25)

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