Assessment of immunotoxicity and genotoxicity in workers exposed to low concentrations of formaldehyde

Archives of Toxicology

Volumn 87, Issue 1, 2013, Pages 145-153

  Aydın, Sevtap ^a   Canpınar, Hande ^a   Ündeğer, Ülkü ^a   Güç, Dicle ^a   Çolakoğlu, Mustafa ^b   Kars, Ayşe ^a   Başaran, Nurşen ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b MINISTRY OF HEALTH   (Turkey)

Author keywords

Complements proteins; DNA damage; Formaldehyde; Lymphocytes; Occupational exposure; Serum immunoglobulins; TNF alpha

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; FORMALDEHYDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; FIELD STUDY; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOTOXICITY; MALE; NATURAL KILLER CELL; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

MAMMALIA; RODENTIA;

EID: 84872305263     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0961-9     Document Type: Article

References (41)

1. ACGIH (American Conference of Governmental Industrial Hygienists) (2003) Documentation of the TLVs-and BEIs-with other worldwide occupational values. CD-ROM,ACGIH, Cincinnati, OH Anderson D, Yu TW, McGregor DB (1998) Comet assay responses as indicators of carcinogen exposure. Mutagenesis 13:539-555
2. Benyajati C, Place AR, Sofer W (1983) Formaldehyde mutagenesis in Drosophila. molecular analysis of ADH-negative mutants. Mutat Res 111:1-7
3. Bolt HM, Degen GH, Hengstler JG (2010) The carcinogenicity debate on formaldehyde: how to derive safe exposure limits? Arch Toxicol 84:421-422
4. Boyum A (1976) Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol 5:9-15
5. Chanet R, von Borstel RC (1979) Genetic effects of formaldehyde in yeast. III. nuclear and cytoplasmic mutagenic effects. Mutat Res 62:239-253
6. Collins AR, Dobson VL, Dusinka M, Kennedy G, Stetina R (1997) The comet assay: what can it really tell us? Mutat Res 375:183-193
7. Costa S, Coelho P, Costa C, Silva S, Mayan O, Santos LS et al (2008) Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology 252:40-48
8. DECOS [Health Council of the Netherlands: Dutch Expert Committee on Occupational Standards] (2003) Formaldehyde. Health-based recommended occupational exposure limit. Health Council of the Netherlands, The Hague publication no. 2003/02OSH
9. DeVoney D, Jinot J, Keshava C, Hsu C, Whalan J, Vandenberg J (2006) A hypothesized mode of action in support of the biological plausibility of formaldehyde-induced lymphohematopoietic malignancies. Society for Risk Analysis, Baltimore, MD
10. DFG (Deutsche Forschungsgemeinschaft of the Federal Republic of Germany) (2000) Formaldehyde. Occupational Toxicants 17:163-201
11. Heck H, Casanova M (1999) Pharmacodynamics of formaldehyde: applications of a model for the arrest of DNA replication by DNA-protein cross-links. Toxicol Appl Pharmacol 160:86-100
12. Heck HA, Casanova M (2004) The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence of distant-side toxicity. Regul Toxicol Pharmacol 40:92-106
13. Hudson L, Hay FC (1991) Practical Immunology, 3rd edn. Blackwell, Oxford
14. IARC (International Agency for Research on Cancer) (2006) Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropanol-2-ol. IARC monographs on the evaluation of carcinogenic risks to humans, vol 88. World Health Organization, Lyon, pp. 39-325
15. IPCS (The International Programme on Chemical Safety) (1989) Environmental health criteria monographs: formaldehyde. http://www.inchem.org/ documents/ehc/ehc/ehc89.htm
16. Kim KH, Jahan SA, Lee JT (2011) Exposure to formaldehyde and its potential human health hazards. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 29:277-299
17. Knasmueller S, Holland N, Wultsch G, Jandl B, Burgaz S, Misík M, Nersesyan A (2011) Use of nasal cells in micronucleus assays and other genotoxicity studies. Mutagenesis 26:231-238
18. Kreiger RA, Garry VF (1983) Formaldehyde-induced cytotoxicity and sister chromatid exchanges in human lymphocyte cultures. Mutat Res 120:51-55
19. Ladeira C, Viegas S, Carolino E, Prista J, Gomes MC, Brito M (2011) Genotoxicity biomarkers in occupational exposure to formaldehyde -the case of histopathology laboratories. Mutat Res 721:15-20
20. Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA (2010) Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicol Sci 116:441-451
21. McGregor D, Bolt H, Cogliano V, Richter-Reichelm HB (2006) Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within he context of the 2006 IPCS human framework for the analysis of a cancer mode of action for humans. Crit Rev Toxicol 36:821-835
22. Merk O, Speit G (1998) Significance of formaldehyde-induced DNAprotein crosslinks for mutagenesis. Environ Mol Mutagen 32:260-268
23. Natarajan AT, Darroudi F, Bussman CJM, van Kesteren-van Leeuwen AC (1983) Evaluation of the mutagenicity of formaldehyde in mammalian cytogenetic assays in vivo and in vitro. Mutat Res 122:355-360
24. Nielsen GD, Wolkoff P (2010) Cancer effects of formaldehyde: A proposal for an indoor air guideline value. Arch Toxicol 84:423-446
25. NIOSH (The National Institute for Occupational Safety and Health) (1994) Formaldehyde: method 3500. NIOSH Manual of Analytical Methods (NMAM), U.S. Department of Health and Human Services, Fourth Edition, 2, 1-5, Cincinnati, OH
26. Nordic Expert Group (2003) The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 132. In: Wibiwo A, Arbete och Hǎlsa (eds), Formaldehyde. Vetenskaplig Skriftserie No. 11: 2003
27. Orsiere T, Sari-Minodier I, Iarmarcovai G, Botta A (2006) Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes. Mutat Res 605:30-41
28. Ren X, Ji Z, McHale CM, Yuh J, Bersonda J, Tang M, Smith MT, Zhang L (2012) The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines. Arch Toxicol [Epub ahead of print]. 10.1007/s00204-012-0911-6
29. Salonen H, Pasanen AL, Lappalainen S, Riuttala H, Tuomi T, Pasanen P (2009) Volatile organic compounds and formaldehyde as explaining factors for sensory irritation in office environments. J Occup Environ Hyg 6:239-247
30. Santovito A, Schiliró T, Castellano S, Cervella P, Bigatti MP, Gilli G, Bono R, DelPero M (2011) Combined analysis of chromosomal aberrations and glutathione S-transferase M1 and T1 polymorphisms in pathologists occupationally exposed to formaldehyde. Arch Toxicol 85:1295-1302
31. SCOEL (Scientific Committee on Occupational Exposure Limits) (2008) Recommendation from the Scientific Committee on Occupational Exposure Limits for formaldehyde. SCOEL/SUM/125, March 2008. European Commission, Luxemburg. Available via http://ec.europa.eu/social/home.jsp?langId=en. Accessed 4 September 2009
32. Shaham J, Gurvich R, Kaufman Z (2002) Sister chromatid exchange in pathology staff occupationally exposed to formaldehyde. Mutat Res 514:115-123
33. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
34. Speit G, Zeller J, Schmid O, Elhajouji A, Ma-Hock L, Neuss S (2009) Inhalation of formaldehyde does not induce systemic genotoxic effects in rats. Mutat Res 677:76-85
35. Sul D, Kim H, Oh E, Phark S, Cho E, Choi S, Kang HS, Kim EM, Hwang KW, Jung WW (2007) Gene expression profiling in lung tissues from rats exposed to formaldehyde. Arch Toxicol 81:589-597
36. Takahashi K, Morita T, Kawazoe Y (1985) Mutagenic characteristics of formaldehyde on bacterial systems. Mutat Res 156:153-161
37. Thompson CM, Grafstrǒm RC (2011) Considerations for the implausibility of leukemia induction by formaldehyde. Toxicol Sci 120:230-232
38. WHO (World Health Organization) (2000) Air quality guidelines for Europe, 2nd edn. World Health Organization, Regional Office for Europe. Copenhagen pp. 87-91
39. Winchester RJ, Ross GD (1986) Methods for enumerating cell populations by surface markers with conventional microscopy. In: Rose NR, Friedman J, Fahey JL (eds) Manual of clinical laboratory immunology, 3rd edn. American Society for Microbiology, Washington, pp 212-225
40. Ye X, Yan W, Xie H, Zhao M, Ying C (2005) Cytogenetic analysis of nasal mucosa cells and lymphocytes from high-level long-term formaldehyde exposed workers and lowlevel short-term exposed waiters. Mutat Res 588:22-27
41. Zeller J, Hǒgel J, Linsenmeyer R, Teller C, Speit G (2012) Investigations of potential susceptibility toward formaldehydeinduced genotoxicity. Arch Toxicol 86:1465-1473