A physiologic-based approach to the evaluation of a patient with hyperphosphatemia

American Journal of Kidney Diseases

Volumn 61, Issue 2, 2013, Pages 330-336

  Leaf, David E ^a   Wolf, Myles ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

calcium sensing receptor; fibroblast growth factor 23; Hyperphosphatemia; hypoparathyroidism; parathyroid hormone

Indexed keywords

CALCIUM ACETATE; CREATININE; HYDROCHLOROTHIAZIDE; MAGNESIUM OXIDE; PARATHYROID HORMONE; PHOSPHATE;

ADULT; ARTICLE; CASE REPORT; CHRONIC KIDNEY DISEASE; CREATININE BLOOD LEVEL; FEMALE; FLUID INTAKE; FOLLOW UP; HUMAN; HYPERCALCIURIA; HYPERPHOSPHATEMIA; HYPOCALCEMIA; HYPOMAGNESEMIA; HYPOPARATHYROIDISM; KIDNEY CALCIFICATION; LABORATORY TEST; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; SODIUM RESTRICTION; ULTRASOUND;

ADULT; FEMALE; HUMANS; HYPERPHOSPHATEMIA;

EID: 84872302491     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2012.06.026     Document Type: Article

References (53)

1. R.V. Thakker Diseases associated with the extracellular calcium-sensing receptor Cell Calcium 35 3 2004 275 282
2. J. Marks, E.S. Debnam, R.J. Unwin Phosphate homeostasis and the renal-gastrointestinal axis Am J Physiol Renal Physiol 299 2 2010 F285 F296
3. Y. Sabbagh, H. Giral, Y. Caldas, M. Levi, S.C. Schiavi Intestinal phosphate transport Adv Chronic Kidney Dis 18 2 2011 85 90
4. G.R. Davis, J.E. Zerwekh, T.F. Parker, G.J. Krejs, C.Y. Pak, J.S. Fordtran Absorption of phosphate in the jejunum of patients with chronic renal failure before and after correction of vitamin D deficiency Gastroenterology 85 4 1983 908 916
5. J. Uribarri Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake Semin Dial 20 4 2007 295 301
6. Y. Sabbagh, S.P. O'Brien, W. Song Intestinal NPT2b plays a major role in phosphate absorption and homeostasis J Am Soc Nephrol 20 11 2009 2348 2358
7. O.M. Gutierrez, M. Wolf Dietary phosphorus restriction in advanced chronic kidney disease: merits, challenges, and emerging strategies Semin Dial 23 4 2010 401 406
8. L. Beck, A.C. Karaplis, N. Amizuka, A.S. Hewson, H. Ozawa, H.S. Tenenhouse Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities Proc Natl Acad Sci U S A 95 9 1998 5372 5377
9. D. Magen, L. Berger, M.J. Coady A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome N Engl J Med 362 12 2010 1102 1109
10. T. Berndt, R. Kumar Novel mechanisms in the regulation of phosphorus homeostasis Physiology (Bethesda) 24 2009 17 25
11. L. Craver, M.P. Marco, I. Martinez Mineral metabolism parameters throughout chronic kidney disease stages 1-5 - achievement of K/DOQI target ranges Nephrol Dial Transplant 22 4 2007 1171 1176
12. T. Isakova, P. Wahl, G.S. Vargas Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease Kidney Int 79 12 2011 1370 1378
13. H.M. Kronenberg NPT2a - the key to phosphate homeostasis N Engl J Med 347 13 2002 1022 1024
14. M.C. Hu, M. Shi, J. Zhang Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule FASEB J 24 9 2010 3438 3450
15. T. Berndt, L.F. Thomas, T.A. Craig Evidence for a signaling axis by which intestinal phosphate rapidly modulates renal phosphate reabsorption Proc Natl Acad Sci U S A 104 26 2007 11085 11090
16. A. Gupta, K. Winer, M.J. Econs, S.J. Marx, M.T. Collins FGF-23 is elevated by chronic hyperphosphatemia J Clin Endocrinol Metab 89 9 2004 4489 4492
17. M.T. Collins, J.R. Lindsay, A. Jain Fibroblast growth factor-23 is regulated by 1alpha,25-dihydroxyvitamin D J Bone Miner Res 20 11 2005 1944 1950
18. J.R. Stubbs, S. Liu, W. Tang Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice J Am Soc Nephrol 18 7 2007 2116 2124
19. A. Benet-Pages, P. Orlik, T.M. Strom, B. Lorenz-Depiereux An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia Hum Mol Genet 14 3 2005 385 390
20. T. Shimada, Y. Yamazaki, M. Takahashi Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism Am J Physiol Renal Physiol 289 5 2005 F1088 F1095
21. E. Eisenberg Effects of serum calcium level and parathyroid extracts on phosphate and calcium excretion in hypoparathyroid patients J Clin Invest 44 1965 942 946
22. E.M. Brown, G. Gamba, D. Riccardi Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid Nature 366 6455 1993 575 580
23. E. Slatopolsky, A. Brown, A. Dusso Role of phosphorus in the pathogenesis of secondary hyperparathyroidism Am J Kidney Dis 37 1 2001 S54 S57 (suppl 2)
24. W.G. Goodman, L.D. Quarles Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics Kidney Int 74 3 2008 276 288
25. J. Cunningham, F. Locatelli, M. Rodriguez Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options Clin J Am Soc Nephrol 6 4 2011 913 921
26. S. Liu, W. Tang, J. Zhou Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D J Am Soc Nephrol 17 5 2006 1305 1315
27. I.Z. Ben-Dov, H. Galitzer, V. Lavi-Moshayoff The parathyroid is a target organ for FGF23 in rats J Clin Invest 117 12 2007 4003 4008
28. S.M. Burnett-Bowie, M.P. Henao, M.E. Dere, H. Lee, B.Z. Leder Effects of hPTH(1-34) infusion on circulating serum phosphate, 1,25-dihydroxyvitamin D, and FGF23 levels in healthy men J Bone Miner Res 24 10 2009 1681 1685
29. V. Lavi-Moshayoff, G. Wasserman, T. Meir, J. Silver, T. Naveh-Many PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop Am J Physiol Renal Physiol 299 4 2010 F882 F889
30. D.M. Antoniucci, T. Yamashita, A.A. Portale Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men J Clin Endocrinol Metab 91 8 2006 3144 3149
31. S.L. Ferrari, J.P. Bonjour, R. Rizzoli Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men J Clin Endocrinol Metab 90 3 2005 1519 1524
32. O. Gutierrez, T. Isakova, E. Rhee Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease J Am Soc Nephrol 16 7 2005 2205 2215
33. H. Hasegawa, N. Nagano, I. Urakawa Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease Kidney Int 78 10 2010 975 980
34. S. Lovekar, J.L. Chen A 90-year-old man with hyperphosphatemia Am J Kidney Dis 57 2 2011 342 346
35. G.S. Markowitz, M.B. Stokes, J. Radhakrishnan, V.D. D'Agati Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure J Am Soc Nephrol 16 11 2005 3389 3396
36. Y. Ori, B. Rozen-Zvi, A. Chagnac Fatalities and severe metabolic disorders associated with the use of sodium phosphate enemas: a single center's experience Arch Intern Med 172 3 2012 263 265
37. S. Ichikawa, E.A. Imel, M.L. Kreiter A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis J Clin Invest 117 9 2007 2684 2691
38. T. Larsson, X. Yu, S.I. Davis A novel recessive mutation in fibroblast growth factor-23 causes familial tumoral calcinosis J Clin Endocrinol Metab 90 4 2005 2424 2427
39. P.D. Mitnick, S. Goldfarb, E. Slatopolsky, J. Lemann Jr, R.W. Gray, Z.S. Agus Calcium and phosphate metabolism in tumoral calcinosis Ann Intern Med 92 4 1980 482 487
40. J.P. Bilezikian, A. Khan, J.T. Potts Jr Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research J Bone Miner Res 26 10 2011 2317 2337
41. R.K. Rude, S.B. Oldham, F.R. Singer Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency Clin Endocrinol (Oxf) 5 3 1976 209 224
42. D. Shoback Clinical practice Hypoparathyroidism N Engl J Med 359 4 2008 391 403
43. G. Mantovani Clinical review: pseudohypoparathyroidism: diagnosis and treatment J Clin Endocrinol Metab 96 10 2011 3020 3030
44. M.R. Pollak, E.M. Brown, H.L. Estep Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation Nat Genet 8 3 1994 303 307
45. F. Raue, C. Haag, E. Schulze, K. Frank-Raue The role of the extracellular calcium-sensing receptor in health and disease Exp Clin Endocrinol Diabetes 114 8 2006 397 405
46. F. Raue, J. Pichl, H.G. Dorr Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey Clin Endocrinol (Oxf) 75 6 2011 760 765
47. I.R. Gunn, D. Gaffney Clinical and laboratory features of calcium-sensing receptor disorders: a systematic review Ann Clin Biochem 41 pt 6 2004 441 458
48. A. Lienhardt, M. Bai, J.P. Lagarde Activating mutations of the calcium-sensing receptor: management of hypocalcemia J Clin Endocrinol Metab 86 11 2001 5313 5323
49. S.H. Pearce, C. Williamson, O. Kifor A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor N Engl J Med 335 15 1996 1115 1122
50. S.D. Mittelman, G.N. Hendy, R.A. Fefferman A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: successful treatment with recombinant human parathyroid hormone J Clin Endocrinol Metab 91 7 2006 2474 2479
51. T.A. Theman, M.T. Collins, D.W. Dempster PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation J Bone Miner Res 24 5 2009 964 973
52. K.K. Winer, C.W. Ko, J.C. Reynolds Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium J Clin Endocrinol Metab 88 9 2003 4214 4220
53. K. Sato, Y. Hasegawa, J. Nakae Hydrochlorothiazide effectively reduces urinary calcium excretion in two Japanese patients with gain-of-function mutations of the calcium-sensing receptor gene J Clin Endocrinol Metab 87 7 2002 3068 3073