Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

Journal of Pharmacology and Pharmacotherapeutics

Volumn 3, Issue 1, 2012, Pages 43-47

  Singh, Surender ^a   Nair, Vinod ^a   Gupta, Yogendra K ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Aphrodisiac; penile erection index; sexual behavior; testosterone; Tribulus terrestris

Indexed keywords

TESTOSTERONE; TRIBULUS TERRESTRIS EXTRACT;

ANIMAL EXPERIMENT; APHRODISIAC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; FEMALE; FRUIT; HYPOPHYSIS GONAD SYSTEM; MALE; NONHUMAN; PENIS ERECTION; RAT; REPEATED DRUG DOSE; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SINGLE DRUG DOSE; SPERMATOZOON COUNT; TESTOSTERONE BLOOD LEVEL; TOXICITY TESTING;

EID: 84872297236     PISSN: 0976500X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0976-500X.92512     Document Type: Article

References (23)

1. Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, et al. Guidelines on Male Sexual Dysfunction: Erectile dysfunction and premature ejaculation. Eur Urol 2010; 57: 804-14.
2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-61.
3. Wagner G, Saenz de TI. Clinical review. Update on male erectile dysfunction. Br Med J 1998; 316: 678-82.
4. Meinhardt W, Kropman RF, Vermeji P. Comparative tolerability and efficacy of treatments of impotence. Drug Saf 1999; 20: 133-46.
5. Khare CP, editor. Indian Medicinal Plants. An illustrated dictionary. Berlin: Springer-Verlag; 2007.
6. Adaikan PG, Gauthaman K, Prasad RN. History of herbal medicines with and insight on Pharmacological properties of Tribulus terrestris. Ageing Male 2001; 4: 163-9.
7. Ministry of Health and Family Welfare; Govt of India. The Ayurvedic Pharmacopoeia of India; 2001.
8. Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002; 71: 1385-96.
9. Gautaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of erectile dysfunction: An evaluation using primates, rabbits and rat. Phytomedicine 2008; 15: 44-54.
10. Brown GA, Vukovich MD, Reifenrath TA, Parsons KA, Sharp RL, King DS. Effects of anabolic precursors on serum testosterone concentration and adaptations to resistance training in young men. Int J Sport Nutr Exer Metabol 2000; 10: 340-59.
11. Matsumoto AM. Effects of chronic testosterone administration in normal men: Safety and efficacy of high dosage testosterone and parallel dosedependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production. J Clin Endocrinol Metab 1990; 70: 282-7.
12. Hull EM, Dominguez JM. Sexual behavior in male rodents. Horm Behav 2007; 52: 45-55.
13. Zanoli P, Rivasi M, Zavatti M, Brusiani F, Vezzalini F, Baraldi M. Activity of single component of Ferula hermonis on male rat sexual behaviour. Int J Impot Res 2005; 17: 513-8.
14. Agmo A. Male rat sexual behavior. Brain Res Brain Res Protoc 1997; 1: 203-9.
15. Benassi-Benelli A, Ferrari F, Quarantotti BP. Penile Erection induced by apomorphine and N-n-propyl-norapomorphine in rats. Arch Int Pharmacodyn Ther 1979; 242: 241-7.
16. Ang HH, Sim MK. Effects of Eurycoma longifolia jack on penile erection index and homosexual mounting in rats. J Pharm Sci 1997; 3: 117-9.
17. Ahmed KA, Venkataraman BV, Mitra SK. Assessment of a polyherbal ayurvedic medicine for sexual activity in rats. Indian Drugs 1999; 36: 576-82.
18. OECD. OECD Guidelines for the testing of chemicals. - 407; 2008.
19. du Plessis SS, de Jongh PS, Franken DR. Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. Fertil Steril 2004; 81: 1026-33.
20. Aversa A, Mazzilli F, Rossi T, Delfino M, Isidori AM, Fabbri A. Effects of sildenafil (Viagra) administration on seminal parameters and post ejaculatory refractory time in normal males. Hum Reprod 2000; 15: 131-4.
21. Lefievre L, De Lamirande E, Gagnon C. The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction. J Androl 2000; 21: 929-37.
22. Tomova M, Gjulemetova R, Zarkova S, Peeva S, Pangarova T, Simova M. Steroidal saponins from Tribulus terrestris L. with a stimulating action on the sexual functions. Varna, Bulgaria: International Conference of Chemistry and Biotechnology of Biologically Active Natural Products; 1981.
23. Burger M, Sikka SC, Bivalacqua TJ, Lamb DJ, Hellstrom WJ. The effect of sildenafil on human sperm motion and function from normal and infertile men. Int J Impot Res 2000; 12: 229-34.