Development and validation of a procedure to isolate viable bone marrow cells from the vertebrae of cadaveric organ donors for composite organ grafting

Cytotherapy

Volumn 14, Issue 1, 2012, Pages 104-113

  Gorantla, Vijay S ^a   Schneeberger, Stefan ^b   Moore, Linda R ^c   Donnenberg, Vera S ^a,c   Zimmerlin, Ludovic ^a,c   Lee, W P Andrew ^b   Donnenberg, Albert D ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

good manufacturing practice; organ transplantation; vertebral bone marrow

Indexed keywords

ALBUMIN; CD45 ANTIGEN; DEOXYRIBONUCLEASE; GENTAMICIN; SODIUM CHLORIDE; STAINLESS STEEL; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN;

ADULT; AGITATION; ARTICLE; BONE MARROW CELL; CADAVER DONOR; CASE REPORT; CD34 SELECTION; CELL ISOLATION; CELL VIABILITY; COMPOSITE GRAFT; FEMALE; FLOW CYTOMETRY; GOOD MANUFACTURING PRACTICE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE COUNT; LUMBAR VERTEBRA; MALE; MESENCHYMAL STEM CELL; ORGAN DONOR; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SOFT TISSUE; VERTEBRA BODY;

EID: 82955231986     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2011.605350     Document Type: Article

References (23)

1. Strong DM. The US Navy Tissue Bank: 50 years on the cutting edge. Cell Tissue Bank. 2000;1:9-16.
2. Sharp TG, Sachs DH, Matthews JG, Maples J, Woody JN, Rosenberg SA. Harvest of human bone marrow directly from bone. J Immunol Methods. 1984;69:187-95. (Pubitemid 14135674)
3. Gao IK, Noga SJ, Wagner JE, Cremo CA, Davis J, Donnenberg AD. Implementation of a semiclosed large scale counterfl ow centrifugal elutriation system. J Clin Apheresis. 1987; 3:154-60. (Pubitemid 17031838)
4. Kashiwagi N, Porter KA, Penn I, Brettschneider L, Starzl TE. Studies of homograft sex and of gamma globulin phenotypes after orthotopic homotransplantation of the human liver. Surg Forum. 1969;20:374-6.
5. Starzl TE, Demetris AJ, Trucco M, Murase N, Ricordi C, Ildstad S, et al. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance. Hepatology. 1993;17:1127-52. (Pubitemid 23187422)
6. Fontes P, Rao AS, Carroll P, Dodson F, Shapiro R, Tzakis A, et al. Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantat on. Lancet. 1994;344:151-5. (Pubitemid 24218877)
7. Fontes P, Rao AS, Reyes J, Furukawa H, Abu-Elmagd K, Jabbour N, et al. Concomitant infusion of unmodifi ed donor bone marrow into unconditioned recipients of intestinal allografts. Transplant Proc. 1996;28:2757-8.
8. Rao AS, Fontes P, Dodson F, Zeevi A, Rugeles MT, Abu- Elmagd K, et al. Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. Transplant Proc. 1996;28:2959-65.
9. Rao AS, Fontes P, Iyengar A, Shapiro R, Dodson F, Corry R, et al. Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: A 44 month follow-up. Transplant Proc. 1997;29:1184-5.
10. Rao AS, Phil D, Fontes P, Iyengar A, Aitouche A, Shapiro R, et al. An attempt to induce tolerance with infusion of donor bone marrow in organ allograft recipients. Adv Exp Med Biol. 1997;417:269-74. (Pubitemid 27427754)
11. Murase N, Ye Q, Nalesnik MA, Demetris AJ, Abu-Elmagd K, Reyes J, et al. Immunomodulation for intestinal transplantation by allograft irradiation, adjunct donor bone marrow infusion, or both. Transplantation. 2000;70: 1632-41. (Pubitemid 32037978)
12. Sahota A, Gao S, Hayes J, Jindal RM. Microchimerism and rejection: A meta-analysis. Clin Transplant. 2000;14:345-50. (Pubitemid 30497139)
13. Starzl TE, Murase N. Microchimerism, macrochimerism, and tolerance. Clin Transplant. 2000;14:351-4.
14. 34+ cell determination by fl ow cytometry. International Society of Hematotherapy and Graft Engineering. J Hematother. 1996;5:213-26.
15. Donnenberg AD, Koch EK, GriffinDL, Stanczak HM, Kiss JE, Carlos TM, et al. Viability of cryopreserved BM progenitor cells stored for more than a decade. Cytotherapy. 2002;4: 157-63. (Pubitemid 34537335)
16. Wilkinson L. Systat, the System for Statistics. 12 ed. Chicago: Systat Software Inc.; 2007.
17. Bender JG, To LB, Williams S, Schwartzberg LS. Defi ning a therapeutic dose of peripheral blood stem cells. J Hematother. 1992;1:329-41.
18. Zimmerlin L, Donnenberg VS, Pfeifer ME, Meyer EM, Peault B, Rubin JP, et al. Stromal vascular progenitors in adult human adipose tissue. Cytometry A. 2010;77A:22-30.
19. Donnenberg AD, Donnenberg VS, GriffinDL, Moore LR, Tekinturhan F, Kormos RL. Intra-operative preparation of autologous bone marrow-derived CD34-enriched cellular products for cardiac therapy. Cytotherapy. 2011;13: 441-8.
20. Millan MT, Shizuru JA, Hoffmann P, Dejbakhsh-Jones S, Scandling JD, Grumet FC, et al. Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation.2002;73:1386-91. (Pubitemid 34547457)
21. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105:1815-22. (Pubitemid 40223708)
22. Fontes P, Rao AS, Ricordi C, Rybka WB, Dodson FS, Broznick B, et al. Human bone marrow obtained from vertebral bodies: Cell isolation, phenotyping, progenitor assay, and transplantation. Transplant Proc. 1994;26:3406-7.
23. Ahrens N, Tormin A, Paulus M, Roosterman D, Salama A, Krenn V, et al. Mesenchymal stem cell content of human vertebral bone marrow. Transplantation. 2004;78:925-9. (Pubitemid 39298539)