The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque

Psychopharmacology

Volumn 225, Issue 1, 2013, Pages 21-30

  Uslaner, Jason M ^a   Eddins, Donnie ^a   Puri, Vanita ^a   Cannon, Christopher E ^a   Sutcliffe, Jane ^b   Chew, Chan Sing ^b   Pearson, Michelle ^a   Vivian, Jeffrey A ^b   Chang, Ronald K ^a   Ray, William J ^c   Kuduk, Scott D ^a   Wittmann, Marion ^d  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Science Park II ^*  (Singapore)

^c Envoy Therapeutics   (United States)

^d BIOGEN   (United States)

Author keywords

Acetylcholine; Alzheimer's disease; Cognition; Muscarinic; Object recognition; Working memory

Indexed keywords

1 [[4 CYANO 4 (PYRIDINE 2 YL)PIPERIDIN 1 YL]METHYL 4 OXO 4 H QUINOLIZINE 3 CARBOXYLIC ACID]; CHOLINERGIC RECEPTOR AFFECTING AGENT; DONEPEZIL; MUSCARINIC M1 RECEPTOR; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; COGNITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; FEMALE; FRONTAL CORTEX; MACACA; MACACA FASCICULARIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; RHESUS MONKEY; SPATIAL MEMORY; TASK PERFORMANCE;

ALLOSTERIC REGULATION; ALZHEIMER DISEASE; ANIMALS; BRAIN; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MACACA FASCICULARIS; MACACA MULATTA; MALE; MICE; PIPERIDINES; QUINOLIZINES; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M1; REGIONAL BLOOD FLOW; SCOPOLAMINE HYDROBROMIDE; SPECIES SPECIFICITY;

EID: 84872286415     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2788-8     Document Type: Article

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