Common variant in FUT2 gene is associated with levels of vitamin B12 in Indian population

Gene

Volumn 515, Issue 1, 2013, Pages 224-228

  Tanwar, Vinay Singh ^a   Chand, Mandeep P ^a   Kumar, Jitender ^a,c   Garg, Gaurav ^a   Seth, Sandeep ^b   Karthikeyan, Ganesan ^b   Sengupta, Shantanu ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Association; FUT2; GWAS; Single nucleotide polymorphism; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FUCOSYL TRANSFERASE 2; TRANSFERASE; UNCLASSIFIED DRUG;

ADULT; AGE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CYANOCOBALAMIN DEFICIENCY; DIABETES MELLITUS; DIET; FEMALE; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HYPERTENSION; INDIA; MALE; POPULATION GENETICS; PRIORITY JOURNAL; REGRESSION ANALYSIS; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VEGETARIAN DIET; VITAMIN BLOOD LEVEL;

ADULT; ALLELES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INDIA; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; VITAMIN B 12;

MAMMALIA;

EID: 84872274498     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.11.021     Document Type: Article

References (50)

1. Albert M.J., Mathan V.I., Baker S.J. Vitamin B12 synthesis by human small intestinal bacteria. Nature 1980, 283:781-782.
2. Baik H.W., Russell R.M. Vitamin B12 deficiency in the elderly. Annu. Rev. Nutr. 1999, 19:357-377.
3. Boren T., Falk P., Roth K.A., Larson G., Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993, 262:1892-1895.
4. Carmel R., Sinow R.M., Karnaze D.S. Atypical cobalamin deficiency. Subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption. J. Lab. Clin. Med. 1987, 109:454-463.
5. Carmel R., Perez-Perez G.I., Blaser M.J. Helicobacter pylori infection and food-cobalamin malabsorption. Dig. Dis. Sci. 1994, 39:309-314.
6. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 1998, 55:1449-1455.
7. Dickey W., Collins J.S., Watson R.G., Sloan J.M., Porter K.G. Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease. Gut 1993, 34:351-353.
8. Fredriksen A., Meyer K., Ueland P.M., Vollset S.E., Grotmol T., Schneede J. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum. Mutat. 2007, 28:856-865.
9. Garg G., et al. Polymorphisms in transcobalamin II gene is associated with coronary artery disease in Indian population. Biomarkers 2012, 17:119-124.
10. Garrod M.G., Allen L.H., Haan M.N., Green R., Miller J.W. Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. Eur. J. Clin. Nutr. 2010, 64:503-509.
11. Gill H.H., Majmudar P., Shankaran K., Desai H.G. Age-related prevalence of Helicobacter pylori antibodies in Indian subjects. Indian J. Gastroenterol. 1994, 13:92-94.
12. Gomber S., Kumar S., Rusia U., Gupta P., Agarwal K.N., Sharma S. Prevalence & etiology of nutritional anaemias in early childhood in an urban slum. Indian J. Med. Res. 1998, 107:269-273.
13. Gomber S., Bhawna N., Madan, Lal A., Kela K. Prevalence & etiology of nutritional anaemia among school children of urban slums. Indian J. Med. Res. 2003, 118:167-171.
14. Graham D.Y., et al. Seroepidemiology of Helicobacter pylori infection in India. Comparison of developing and developed countries. Dig. Dis. Sci. 1991, 36:1084-1088.
15. Haggarty P. B-vitamins, genotype and disease causality. Proc. Nutr. Soc. 2007, 66:539-547.
16. Hall C.A., Finkler A.E. Measurement of the amounts of the individual vitamin B12 binding proteins in plasma. II. Abnormalities in leukemia and pernicious anemia. Blood 1966, 27:618-622.
17. Hanumante N.M., Wadia R.S., Deshpande S.S., Sanwalka N.J., Vaidya M.V., Khadilkar A.V. Vitamin B12 and homocysteine status in asymptomatic Indian toddlers. Indian J. Pediatr. 2008, 75:751-753.
18. Hazra A., et al. Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat. Genet. 2008, 40:1160-1162.
19. Hazra A., et al. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum. Mol. Genet. 2009, 18:4677-4687.
20. Jais M., Barua S. Seroprevalence of anti Helicobacter pylori IgG/IgA in asymptomatic population from Delhi. J. Commun. Dis. 2004, 36:132-135.
21. Kang J.H., Irizarry M.C., Grodstein F. Prospective study of plasma folate, vitamin B12, and cognitive function and decline. Epidemiology 2006, 17:650-657.
22. Kaptan K., et al. Helicobacter pylori-is it a novel causative agent in vitamin B12 deficiency?. Arch. Intern. Med. 2000, 160:1349-1353.
23. Kelly R.J., Rouquier S., Giorgi D., Lennon G.G., Lowe J.B. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J. Biol. Chem. 1995, 270:4640-4649.
24. Krishnaveni G.V., et al. Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes. Diabetologia 2009, 52:2350-2358.
25. Kumar J., Das S.K., Sharma P., Karthikeyan G., Ramakrishnan L., Sengupta S. Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population. J. Hum. Genet. 2005, 50:655-663.
26. Kumar J., et al. Vitamin B12 deficiency is associated with coronary artery disease in an Indian population. Clin. Chem. Lab. Med. 2009, 47:334-338.
27. Kumar J., Garg G., Karthikeyan G., Sengupta S. Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population. Biomarkers 2010, 15:283-287.
28. McCully K.S. Homocysteine, vitamins, and vascular disease prevention. Am. J. Clin. Nutr. 2007, 86:1563S-1568S.
29. Mills J.L., et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995, 345:149-151.
30. Pathak P., Kapil U., Yajnik C.S., Kapoor S.K., Dwivedi S.N., Singh R. Iron, folate, and vitamin B12 stores among pregnant women in a rural area of Haryana State, India. Food Nutr. Bull. 2007, 28:435-438.
31. Quadros E.V., Regec A.L., Khan K.M., Quadros E., Rothenberg S.P. Transcobalamin II synthesized in the intestinal villi facilitates transfer of cobalamin to the portal blood. Am. J. Physiol. 1999, 277:G161-G166.
32. Refsum H., et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am. J. Clin. Nutr. 2001, 74:233-241.
33. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006, 5:949-960.
34. Robinson K., et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 1995, 92:2825-2830.
35. Rosenthal A., Coutelle O., Craxton M. Large-scale production of DNA sequencing templates by microtitre format PCR. Nucleic Acids Res. 1993, 21:173-174.
36. Schwartz S.M., et al. Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. Circulation 1997, 96:412-417.
37. Seetharam B. Receptor-mediated endocytosis of cobalamin (vitamin B12). Annu. Rev. Nutr. 1999, 19:173-195.
38. Selhub J., Morris M.S., Jacques P.F., Rosenberg I.H. Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am. J. Clin. Nutr. 2009, 89:702S-706S.
39. Serpa J., et al. Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G->A and 839T->C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal. Biochem. J. 2004, 383:469-474.
40. Sivakumar B., et al. Effect of micronutrient supplement on health and nutritional status of schoolchildren: biochemical status. Nutrition 2006, 22:S15-S25.
41. Splaver A., Lamas G.A., Hennekens C.H. Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials. Am. Heart J. 2004, 148:34-40.
42. Stanislawska-Sachadyn A., et al. The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status. Eur. J. Clin. Nutr. 2010, 64:1338-1343.
43. Tanaka T., et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am. J. Hum. Genet. 2009, 84:477-482.
44. Taneja S., et al. Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am. J. Clin. Nutr. 2007, 86:1302-1309.
45. Watanabe F. Vitamin B12 sources and bioavailability. Exp. Biol. Med. (Maywood) 2007, 232:1266-1274.
46. Watkins W.M. Biochemistry and genetics of the ABO, Lewis, and P blood group systems. Adv. Hum. Genet. 1980, 10(1-136):379-385.
47. Weir D.G., Scott J.M. Brain function in the elderly: role of vitamin B12 and folate. Br. Med. Bull. 1999, 55:669-682.
48. Yajnik C.S., et al. Maternal total homocysteine concentration and neonatal size in India. Asia Pac. J. Clin. Nutr. 2005, 14:179-181.
49. Yajnik C.S., et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 2008, 51:29-38.
50. Zhang S.M., et al. Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J. Natl. Cancer Inst. 2003, 95:373-380.