Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M 2 KO animals

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 12, 2012, Pages 1161-1173

  Benes, Jan ^a   Varejkova, Eva ^a   Farar, Vladimir ^a   Novakova, Martina ^a   Myslivecek, Jaromir ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Activity; Beta adrenoceptors; Biorhythms; Echocardiography; Heart rate; M2 muscarinic receptor knockout; Telemetry; Temperature

Indexed keywords

ADENYLATE CYCLASE; ATROPINE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CARBACHOL; CATECHOLAMINE; ISOPRENALINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; PROPRANOLOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; BRADYCARDIA; CARDIOVASCULAR PARAMETERS; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FRACTIONAL SHORTENING; GENE EXPRESSION; HEART FUNCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART RATE VARIABILITY; HEART RHYTHM; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE FUNCTION; KNOCKOUT MOUSE; MALE; MITRAL FLOW; MOUSE; NONHUMAN; RECEPTOR BINDING;

ANIMALS; ATROPINE; BRADYCARDIA; CARBACHOL; GENE EXPRESSION REGULATION; HEART RATE; HEART VENTRICLES; ISOPROTERENOL; MALE; MICE; MICE, KNOCKOUT; PROPRANOLOL; PROTEIN BINDING; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; VENTRICULAR FUNCTION, LEFT;

EID: 84872265705     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0800-9     Document Type: Article

References (46)

1. Arraj M, Lemmer B (2006) Circadian rhythms in heart rate, motility, and body temperature of wild-type C57 and eNOS knock out mice under light-dark, free run, and after time zone transition. Chronobiol Int 23:795-812
2. Benes J, Novakova M, Rotkova J, Farar V, Kvetnansky R, Riljak V, Myslivecek J (2012) Beta3 adrenoceptors substitute the role of M2 muscarinic receptor in coping with cold stress in the heart: evidence from M2KO mice. Cell Mol Neurobiol 32:589-869
3. Boknik P, Grote-Wessels S, Barteska G, Jiang M, Müller FU, Schmitz W, Neumann J, Birnbaumer L (2009) Genetic disruption of G proteins, Gi2α or Goα, does not abolish inotropic and chrono-tropic effects of stimulating muscarinic cholinoceptors in atrium. Br J Pharmacol 158:1557-1564
4. Brodde OE (2008) Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol Ther 117:1-29
5. Brodde OE, Leineweber K (2004) Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur J Pharmacol 500:167-176
6. Burnstock G (2009) Autonomic neurotransmission: 60 years since Sir Henry Dale. Annu Rev Pharmacol Toxicol 49:1-30
7. Bymaster FP, Carter PA, Zhang L, Falcone JF, Stengel PW, Cohen ML, Shannon HE, Gomeza J, Wess J, Felder CC (2001) Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice. Life Sci 68:2473-2479
8. Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK (1999) Targeted disruption of the beta 2 adrenergic receptor gene. J Biol Chem 274:16694-16700
9. Ecker PM, Lin CC, Powers J, Kobilka BK, Dubin AM, Bernstein D (2006) Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability. Am J Physiol Heart Circ Physiol 290:H192-H199
10. Fasano C, Niel J-P (2009) The mammalian sympathetic prevertebral ganglia: models for the study of neuronal networks and basic neuronal properties. Auton Neurosci 150:8-20
11. Fisher JT, Vincent SG, Gomeza J, Yamada M, Wess J (2004) Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J 18:711-713
12. Garofolo MC, Seidler FJ, Auman JT, Slotkin TA (2002) Beta-adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. Am J Physiol Regul Integr Comp Physiol 282:R1356-R1363
13. Giménez LED, Hernández CCQ, Mattos EC, Brandão IT, Olivieri B, Campelo RP, Araújo-Jorge T, Silva CL, Campos de Carvalho AC, Kurtenbach E (2005) DNA immunizations with M2 muscarinic and β1 adrenergic receptor coding plasmids impair cardiac function in mice. J Mol Cell Cardiol 38:703-714
14. Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, Brodkin J, Grinberg A, Sheng H, Wess J (1999) Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci USA 96:1692-1697
15. Gomeza J, Zhang L, Kostenis E, Felder CC, Bymaster FP, Brodkin J, Shannon H, Xia B, Duttaroy A, Deng CX, Wess J (2001) Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice. Life Sci 68:2457-2466
16. Göttle M, Geduhn J, König B, Gille A, Höcherl K, Seifert R (2009) Characterization of mouse heart adenylyl cyclase. J Pharmacol Exp Ther 329:1156-1165
17. Grouzmann E, Cavadas C, Grand D, Moratel M, Aubert J-F, Brunner H, Mazzolai L (2003) Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice. Pflügers Arch Eur J Physiol 447:254-258
18. Hoffert JD, Chou CL, Fenton RA, Knepper MA (2005) Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. J Biol Chem 280:13624-13630
19. Imeri L, Bianchi S, Angeli P, Mancia M (1996) Muscarinic receptor subtypes in the medial preoptic area and sleep-wake cycles. Neuroreport 7:417-420
20. Ito Y, Oyunzul L, Seki M, Fujino T, Matsui M, Yamada S (2009) Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice. Br J Pharmacol 156:1147-1153
21. Kiriazis H, Wang K, Xu Q, Gao XM, Ming Z, Su Y, Moore XL, Lambert G, Gibbs ME, Dart AM, Du XJ (2008) Knockout of β1- and β2-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis. Br J Pharmacol 153:684-692
22. Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, S-i K, Yamada M, Wess J (2009) M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with musca-rinic receptor knockout mice. J Pharmacol Exp Ther 330:487-493
23. LaCroix C, Freeling J, Giles A, Wess J, Li Y-F (2008) Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress. Am J Physiol Heart Circ Physiol 294:H810-H820
24. Lee NH, Fraser CM (1993) Cross-talk between m1 muscarinic acetyl-choline and beta 2-adrenergic receptors. cAMP and the third intracellular loop of m1 muscarinic receptors confer heterologous regulation. J Biol Chem 268:7949-7957
25. Lee S, Grafweg S, Schneider T, Jimenez M, Giacobino JP, Ghanem A, Tiemann K, Bloch W, Muller-Ehmsen J, Schwinger RH, Brixius K (2010) Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy. Physiological Research/Aca-demia Scientiarum Bohemoslovaca 59:679-689
26. Myslivecek J, Trojan S, Tucek S (1996) Biphasic changes in the density of muscarinic and beta-adrenergic receptors in cardiac atria of rats treated with diisopropylfluorophosphate. Life Sci 58:2423-2430
27. Myslivecek J, Lisa V, Trojan S, Tucek S (1998) Heterologous regulation of muscarinic and beta-adrenergic receptors in rat cardiomyocytes in culture. Life Sci 63:1169-1182
28. Myslivecek J, Duysen EG, Lockridge O (2007) Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice. Naunyn Schmiedebergs Arch Pharmacol 376:83-92
29. Myslivecek J, Klein M, Novakova M, Ricny J (2008) The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles. Naunyn Schmiedebergs Arch Pharmacol 378:103-116
30. Ondicova K, Mravec B (2010) Multilevel interactions between the sympathetic and parasympathetic nervous systems: a minireview. Endocr Regul 44:69-75
31. Paraschos A, Karliner JS (1994) Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol 350:267-276
32. Racké K, Juergens UR, Matthiesen S (2006) Control by cholinergic mechanisms. Eur J Pharmacol 533:57-68
33. Rhodes ME, Billings TE, Czambel RK, Rubin RT (2005) Pituitary-adrenal responses to cholinergic stimulation and acute mild stress are differentially elevated in male and female M2 muscarinic receptor knockout mice. J Neuroendocrinol 17:817-826
34. Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DP Jr, Barsh GS, Bernstein D, Kobilka BK (1996) Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci USA 93:7375-7380
35. Stavrakis S, Kem DC, Patterson E, Lozano P, Huang S, Szabo B, Cunningham MW, Lazzara R, Yu X (2011) Opposing cardiac effects of autoantibody activation of beta-adrenergic and M2 muscarinic receptors in cardiac-related diseases. Int J Cardiol 148:331-336
36. Stengel PW, Gomeza J, Wess J, Cohen ML (2000) M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro. J Pharmacol Exp Ther 292:877-885
37. Swoap SJ, Li C, Wess J, Parsons AD, Williams TD, Overton JM (2008) Vagal tone dominates autonomic control of mouse heart rate at ther-moneutrality. Am J Physiol Heart Circ Physiol 294:H1581-H1588
38. Tanaka N, Dalton N, Mao L, Rockman HA, Peterson KL, Gottshall KR, Hunter JJ, Chien KR, Ross J (1996) Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation 94:1109-1117
39. Trendelenburg A-U, Meyer A, Wess J, Starke K (2005) Distinct mixtures of muscarinic receptor subtypes mediate inhibition of nor-adrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice. Br J Pharmacol 145:1153-1159
40. Wang Z, Shi H, Wang H (2004) Functional M3 muscarinic acetylcho-line receptors in mammalian hearts. Br J Pharmacol 142:395-408
41. Wang H, Lu Y, Wang Z (2007) Function of cardiac M3 receptors. Auton Autacoid Pharmacol 27:1-11
42. 2+. Biochem J 374:281-296
43. Wess J, Duttaroy A, Zhang W, Gomeza J, Cui Y, Miyakawa T, Bymaster FP, McKinzie L, Felder CC, Lamping KG, Faraci FM, Deng C, Yamada M (2003) M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cho-linergic system. Receptors Channels 9:279-290
44. Willmy-Matthes P, Leineweber K, Wangemann T, Silber RE, Brodde OE (2003) Existence of functional M3-muscarinic receptors in the human heart. Naunyn Schmiedebergs Arch Pharmacol 368:316-319
45. Yang T, Levy M (1984) The phase-dependency of the cardiac chrono-tropic responses to vagal stimulation as a factor in sympathetic-vagal interactions. Circ Res 54:703-710
46. Zhou H, Meyer A, Starke K, Gomeza J, Wess J, Trendelenburg AU (2002) Heterogeneity of release-inhibiting muscarinic autorecep-tors in heart atria and urinary bladder: a study with M(2)- and M (4)-receptor-deficient mice. Naunyn Schmiedebergs Arch Pharmacol 365:112-122