TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity

Journal of Investigative Dermatology

Volumn 133, Issue 1, 2013, Pages 135-143

  Mohammed, Javed ^a   Gunderson, Andrew J ^a   Khong, Hong Hanh ^a   Koubek, Richard D ^a   Udey, Mark C ^b   Glick, Adam B ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; CD86 ANTIGEN; LANGERIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTACT ALLERGY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENE OVEREXPRESSION; HOMEOSTASIS; IMMUNE RESPONSE; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL;

EID: 84872194186     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.241     Document Type: Article

References (46)

1. Akhurst RJ, Fee F, Balmain A (1988) Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis. Nature 331:363-55
2. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245-522
3. Bogunovic M, Ginhoux F, Wagers A et al. (2006) Identification of a radioresistant and cycling dermal dendritic cell population in mice and men. J Exp Med 203:2627-388
4. Borkowski TA, Letterio JJ, Farr AG et al. (1996) A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 184:2417-222
5. Borkowski TA, Letterio JJ, Mackall CL et al. (1997) A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice. J Clin Invest 100:575-811
6. Coquerelle C, Moser M (2010) DC subsets in positive and negative regulation of immunity. Immunol Rev 234:317-344
7. Dakic A, Shao QX, D'Amico A et al. (2004) Development of the dendritic cell system during mouse ontogeny. J Immunol 172:1018-277
8. Fainaru O, Shay T, Hantisteanu S et al. (2007) TGFbeta-dependent gene expression profile during maturation of dendritic cells. Genes Immun 8:239-444
9. Fitch EL, Rizzo HL, Kurtz SE et al. (2009) Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th177 inflammatory pathway. J Invest Dermatol 129:2443-500
10. Flisiak I, Chodynicka B, Porebski P et al. (2002) Association between psoriasis severity and transforming growth factor beta(1) and beta (2) in plasma and scales from psoriatic lesions. Cytokine 19:121-55
11. Flisiak I, Porebski P, Flisiak R et al. (2003) Plasma transforming growth factor beta1 as a biomarker of psoriasis activity and treatment efficacy. Biomarkers 8:437-433
12. Gaiser MR, Lammermann T, Feng X et al. (2012) Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proc Natl Acad Sci USA 109:E889-977
13. Geissmann F, Revy P, Regnault A et al. (1999) TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol 162:4567-755
14. Gilliet M, Cao W, Liu YJ (2008) Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol 8:594-6066
15. Ginhoux F, Merad M (2010) Ontogeny and homeostasis of Langerhans cells. Immunol Cell Biol 88:387-922
16. Glick AB, Sporn MB, Yuspa SH (1991) Altered regulation of TGF-b 1 and TGF-a in primary keratinocytes and papillomas expressing v-Ha-ras. Mol Carcinog 4:210-99
17. Gregorio J, Meller S, Conrad C et al. (2010) Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 207:2921-300
18. Guiducci C, Tripodo C, Gong M et al. (2010) Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med 207:2931-422
19. Han G, Williams CA, Salter K et al. (2010) A role for TGFbeta signaling in the pathogenesis of psoriasis. J Invest Dermatol 130:371-77
20. Hawiger D, Inaba K, Dorsett Y et al. (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194:769-799
21. Henri S, Poulin LF, Tamoutounour S et al. (2010) CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207:189-2066
22. Kane CJ, Hebda PA, Mansbridge JN et al. (1991) Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing. J Cell Physiol 148:157-733
23. Kane CJ, Knapp AM, Mansbridge JN et al. (1990) Transforming growth factorbeta 1 localization in normal and psoriatic epidermal keratinocytes in situ. J Cell Physiol 144:144-500
24. Kaplan DH, Li MO, Jenison MC et al. (2007) Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med 204:2545-522
25. Kel JM, Girard-Madoux MJ, Reizis B et al. (2010) TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis. J Immunol 185:3248-555
26. Kissenpfennig A, Henri S, Dubois B et al. (2005) Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643-544
27. Levine JH, Moses HL, Gold LI et al. (1993) Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 33 during excisional wound repair. Am J Pathol 143:368-800
28. Li AG, Wang D, Feng XH et al. (2004) Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J 23:1770-811
29. Liu X, Alexander V, Vijayachandra K et al. (2001) Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia. Proc Natl Acad Sci USA 98:9139-444
30. Merad M, Ginhoux F, Collin M (2008) Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 8:935-477
31. Merad M, Manz MG, Karsunky H et al. (2002) Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3:1135-411
32. Michaelis K, Wallbrecht K, Kerstan A et al. (2010) Modulating T cell functions does not alleviate chronic inflammatory skin lesions in K5.TGF beta 11 transgenic mice. Exp Dermatol 19:406-155
33. Mohammed J, Ryscavage A, Perez-Lorenzo R et al. (2010) TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17. J Invest Dermatol 130:2295-3033
34. Nagao K, Ginhoux F, Leitner WW et al. (2009) Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci USA 106:3312-77
35. Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361:496-5099
36. Ohl L, Mohaupt M, Czeloth N et al. (2004) CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279-888
37. Ohtani T, Mizuashi M, Nakagawa S et al. (2009) TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation. Immunology 126:485-999
38. Palamara F, Meindl S, Holcmann M et al. (2004) Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod. J Immunol 173:3051-611
39. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-966
40. Steinman RM, Turley S, Mellman I et al. (2000) The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 191: 411-66
41. Stoitzner P, Zanella M, Ortner U et al. (1999) Migration of langerhans cells and dermal dendritic cells in skin organ cultures: Augmentation by TNF-alpha and IL-1beta. J Leukoc Biol 66:462-700
42. Strobl H, Knapp W (1999) TGF-beta1 regulation of dendritic cells. Microbes Infect 1:1283-900
43. Torres-Aguilar H, guilar-Ruiz SR, Gonzalez-Perez G et al. (2010) Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells. J Immunol 184:1765-755
44. Waithman J, Allan RS, Kosaka H et al. (2007) Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells. J Immunol 179:4535-411
45. Wang XJ, Han G, Owens P et al. (2006) Role of TGF beta-mediated inflammation in cutaneous wound healing. J Investig Dermatol Symp Proc 11:112-77
46. Zahner SP, Kel JM, Martina CA et al. (2011) Conditional deletion of TGF- {beta}R1 using Langerin-Cre mice results in langerhans cell deficiency and reduced contact hypersensitivity. J Immunol 187:5069-766