Heterogeneous abnormalities of in-vivo left ventricular calcium influx and function in mouse models of muscular dystrophy cardiomyopathy

Journal of Cardiovascular Magnetic Resonance

Volumn 15, Issue 1, 2013, Pages

  Greally, Elizabeth ^a   Davison, Benjamin J ^a   Blain, Alison ^a   Laval, Steve ^a   Blamire, Andrew ^b   Straub, Volker ^a   MacGowan, Guy A ^a,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c FREEMAN HOSPITAL   (United Kingdom)

Author keywords

Calcium; Cardiomyopathy; Magnetic resonance imaging; Muscular dystrophy

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CALCIUM; DILTIAZEM; MANGANESE CHLORIDE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CHLORIDE; CONTRAST MEDIUM; DIAGNOSTIC AGENT; MANGANESE DERIVATIVE; SARCOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALCIUM TRANSPORT; CARDIOMYOPATHY; CARDIOVASCULAR MAGNETIC RESONANCE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; GROUPS BY AGE; HEART INDEX; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; IN VIVO STUDY; MALE; MOUSE; MOUSE MODEL; MUSCULAR DYSTROPHY; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE; AGE; ANIMAL; CALCIUM SIGNALING; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DUCHENNE MUSCULAR DYSTROPHY; GENETICS; GENOTYPE; HEART MUSCLE; METABOLISM; MOUSE MUTANT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; TIME;

AGE FACTORS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARDIOMYOPATHIES; CHLORIDES; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENOTYPE; HEART RATE; HYPERTROPHY, LEFT VENTRICULAR; MAGNETIC RESONANCE IMAGING; MALE; MANGANESE COMPOUNDS; MICE; MICE, INBRED MDX; MICE, KNOCKOUT; MUSCULAR DYSTROPHY, DUCHENNE; MYOCARDIUM; PHENOTYPE; SARCOGLYCANS; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

MLCS; MLOWN;

EID: 84872178206     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/1532-429X-15-4     Document Type: Article

References (24)

1. Bushby K, Muntoni F, Bourke JP. 107th ENMC international workshop: The management of cardiac involvement in muscular dystrophy and myotonic dystrophy. 7th-9th June 2002, Naarden, the Netherlands. Neuromuscul Disord 2003; 13:166-72.
2. Finsterer J, Stollberger C. The heart in human dystrophinopathies. Cardiology 2003; 99:1-19.
3. Politano L, Nigro V, Passamano L, Petretta V, Comi LI, Papparella S, Nigro G, Rambaldi PF, Raia P, Pini A, Mora M, Giugliano MA, Esposito MG, Nigro G. Evaluation of cardiac and respiratory involvement in sarcoglycanopathies. Neuromuscul Disord 2001; 11:178-85.
4. Yasuda S, Townsend D, Michele DE, Favre EG, Day SM, Metzger JM. Dystrophic heart failure blocked by membrane sealant poloxamer. Nature 2005; 436 7053:1025.
5. Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 1998; 281 5383:1690-3.
6. Williams IA, Allen DG. The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice. Am J Physiol Heart Circ Physiol 2007; 293 3: H1969-H77.
7. Fraysse B, Nagi SM, Boher B, Ragot H, Lainé J, Salmon A, Fiszman MY, Toussaint M, Fromes Y. Ca2+ overload and mitochondrial permeability transition pore activation in living delta-sarcoglycan-deficient cardiomyocytes. Am J Physiol Cell Physiol 2010; 299 3:C706-C13.
8. Cohn RD, Durbeej M, Moore SA, Coral-Vazquez R, Prouty S, Campbell KP. Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex. J Clin Invest 2001; 107:153-4.
9. Wheeler MT, Allikian MJ, Heydemann A, Hadhazy M, Zarnegar S, McNally EM. Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. J Clin Invest 2004; 113 5:668-75.
10. Bauer R, Blain A, Greally E, Bushby K, Lochmüller H, Laval S, Straub V, MacGowan GA. Intolerance to ß-blockade in a mouse model of δ- sarcoglycan-deficient muscular dystrophy cardiomyopathy. Eur J Heart Fail 2010; 12 11:1163-70.
11. Hu TC, Pautler RG, MacGowan GA, Koretsky AP. Manganese-enhanced MRI of mouse heart during changes in inotropy. Magn Reson Med 2001; 46 5:884-90.
12. Quinlan JG, Hahn HS, Wong BL, Lorenz JN, Wenisch AS, Levin LS. Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings. Neuromuscul Disord 2004; 14:491-6.
13. Coral-Vazquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson RL, Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R, Campbell KP. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: A novel mechanism for cardiomyopathy and muscular dystrophy. Cell 1999; 98:465-474.
14. Schneider JE, Wiesmann F, Lygate CA, Neubauer S. How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging. J Cardiovasc Magn Reson 2006; 8 5:693-701.
15. Heiberg E, Wigström L, Carlsson M, Bolger AF, Karlsson M. Time Resolved Three-dimensional Automated Segmentation of the Left Ventricle. In Proceedings of IEEE Computers in Cardiology, Lyon, France 2005; 32:599-602.
16. Liu J, Noblea PJ, Xiaoa G, Abdelrahmana M, Dobrzynskib H, Boyettb MR, Leib M, Noble D. Role of pacemaking current in cardiac nodes: Insights from a comparative study of sinoatrial node and atrioventricular node. Prog Biophys Mol Biol 2008; 96:294-304.
17. Hogan N, Casadei B, Paterson DJ. Nitric oxide donors can increase heart rate independent of autonomic activation. J Appl Physiol 1999; 87 1:97-103.
18. Williams IA, Allen DG. Intracellular calcium handling in ventricular myocytes from mdx mice. Am J Physiol Heart Circ Physiol 2007; 292 2:H846-H55.
19. Vandsburger MH, French BA, Kramer CM, Zhong X, Epstein FH. Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. Am J Physiol Heart Circ Physiol 2012; 302 2:H412-H9.
20. Yu X, Chen XW, Zhou P, Yao L, Liu T, Zhang B, Li Y, Zheng H, Zheng LH, Zhang CX, Bruce I, Ge JB, Wang SQ, Hu ZA, Yu HG, Zhou Z. Calcium influx through If channels in rat ventricular myocytes. Am J Physiol Cell Physiol 2007; 292 3:C1147-C55.
21. Newsom DM, Bolgos GL, Colby L, Nemzek JA. Comparison of body surface temperature measurement and conventional methods for measuring temperature in the mouse. Contemp Top Lab Anim Sci 2004. 43 5:13-18.
22. Isenberg G, Borschke B, Rueckschloss U. Ca2+ transients of cardiomyocytes from senescent mice peak late and decay slowly. Cell Calcium 2003; 34:271-80.
23. Salameh A, Dhein S, Fleischmann B, Grohe C, Hescheler J, Linz KW, Meyer R. The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts. J Physiol Pharmacol 2010; 61 2:141-51.
24. Townsend D, Yasuda S, McNally E, Metzger JM. Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex. FASEB J 2011; 25:3106-3114.