Intolerance to β-blockade in a mouse model of δ-sarcoglycan- deficient muscular dystrophy cardiomyopathy

European Journal of Heart Failure

Volumn 12, Issue 11, 2010, Pages 1163-1170

  Bauer, Ralf ^a,b   Blain, Alison ^a   Greally, Elizabeth ^a   Bushby, Kate ^a   Lochmüller, Hanns ^a   Laval, Steve ^a   Straub, Volker ^a   MacGowan, Guy A ^a,b,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c FREEMAN HOSPITAL   (United Kingdom)

Author keywords

Blockers; Cardiomyopathy; Mouse models; Muscular dystrophy

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DELTA SARCOGLYCAN; DOBUTAMINE; MESSENGER RNA; METOPROLOL; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CARDIOMYOPATHY; CONTROLLED STUDY; DRUG EFFECT; DUCHENNE MUSCULAR DYSTROPHY; GENOTYPE; HEART AFTERLOAD; HEART HEMODYNAMICS; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE FIBROSIS; HEART STROKE VOLUME; HISTOPATHOLOGY; IN VIVO STUDY; LIMB GIRDLE MUSCULAR DYSTROPHY; MALE; MEMBRANE DAMAGE; MOUSE; MUSCULAR DYSTROPHY; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; DISEASE MODEL; HEART FAILURE; HEART PAPILLARY MUSCLE; HEMODYNAMICS; MOUSE STRAIN; PATHOLOGY; PATHOPHYSIOLOGY; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ADRENERGIC BETA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; DISEASE MODELS, ANIMAL; DOBUTAMINE; HEART FAILURE; HEMODYNAMICS; METOPROLOL; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MICE, INBRED STRAINS; MUSCULAR DYSTROPHIES, LIMB-GIRDLE; MUSCULAR DYSTROPHY, DUCHENNE; PAPILLARY MUSCLES;

EID: 77958540680     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfq129     Document Type: Article

References (32)

1. Muntoni F. Cardiomyopathy in muscular dystrophies. Curr Opin Neurol 2003;16: 577-583.
2. Heydemann A, McNally EM. Consequences of disrupting the dystrophin-sarco-glycan complex in cardiac and skeletal myopathy. Trends Cardiovasc Med 2007; 17:55-59.
3. Bushby K, Muntoni F, Bourke JP. 107th ENMC international workshop: the management of cardiac involvement in muscular dystrophy and myotonic dystrophy. 7th-9th June 2002, Naarden, the Netherlands. Neuromuscul Disord 2003;13: 166-172.
4. Finsterer J, Stollberger C. The heart in human dystrophinopathies. Cardiology 2003;99:1-19.
5. Politano L, Nigro V, Passamano L, Petretta V, Comi LI, Papparella S, Nigro G, Rambaldi PF, Raia P, Pini A, Mora M, Giugliano MA, Esposito MG, Nigro G. Evaluation of cardiac and respiratory involvement in sarcoglycanopathies. Neuromuscul Disord 2001;11:178-185.
6. Bristow MR. Beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000;101:558-569.
7. Eichhorn EJ, Heesch CM, Barnett JH, Alvarez LG, Fass SM, Grayburn PA, Hatfield BA, Marcoux LG, Malloy CR. Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol 1994;24: 1310-1320.
8. Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, Shusterman NH. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med 1996;334:1349-1355.
9. Tominaga M, Matsumori A, Okada I, Yamada T, Kawai C. Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice. Circulation 1991; 83:2021-2028.
10. Waagstein F, Hjalmarson A, Varnauskas E, Wallentin I. Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J 1975;37:1022-1036.
11. Jefferies JL, Eidem BW, Belmont JW, Craigen WJ, Ware SM, Fernbach SD, Neish SR, Smith EO, Towbin JA. Genetic predictors and remodeling of dilated cardiomyopathy in muscular dystrophy. Circulation 2005;112:2799-2804.
12. Witte K, Schnecko A, Hauth D, Wirzius S, Lemmer B. Effects of chronic application of propranolol on beta-adrenergic signal transduction in heart ventricles from myopathic BIO TO2 and control hamsters. Br J Pharmacol 1998;125: 1033-1041.
13. Nishizawa T, Iwase M, Kanazawa H, Ichihara S, Ichihara G, Nagata K, Obata K, Kitaichi K, Yokoi T, Watanabe M, Tsunematsu T, Ishikawa Y, Murohara T, Yokota M. Serial alterations of beta-adrenergic signaling in dilated cardiomyo-pathic hamsters: possible role of myocardial oxidative stress. Circ J 2004;68: 1051-1060.
14. Coral-Vazquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson RL, Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R, Campbell KP. Disruption of the sar-coglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell 1999;98:465-474.
15. Quinlan JG, Hahn HS, Wong BL, Lorenz JN, Wenisch AS, Levin LS. Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings. Neuro-muscul Disord 2004;14:491-496.
16. Bauer R, MacGowan GA, Blain A, Bushby K, Straub V. Steroid treatment causes deterioration of myocardial function in the d-sarcoglycan-deficient mouse model for dilated cardiomyopathy. Cardiovasc Res 2008;79:652-661.
17. Bauer R, Straub V, Blain A, Bushby K, MacGowan GA. Contrasting effects of steroids and ACE inhibitors in a mouse model of dystrophin-deficient cardiomyo-pathy. Eur J Heart Fail 2009;11:463-471.
18. Bauer R, Blain A, Greally E, Lochmüller H, Bushby K, MacGowan GA, Straub V. Attenuation of adverse cardiac effects in prednisolone-treated delta-sarcoglycan-deficient mice by mineralocorticoid-receptor-antagonism. Neu-romuscul Disord 2010;20:21-28.
19. Steendijk P, Staal E, Jukema JW, Baan J. Hypertonic saline method accurately determines parallel conductance for dual-field conductance catheter. Am J Physiol Heart Circ Physiol 2001;281:H755-H763.
20. Suga H, Sagawa K. Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle. Circ Res 1974;35:117-126.
21. Glower DD, Spratt JA, Snow ND, Kabas JS, Davis JW, Olsen CO, Tyson GS, Sabiston DC Jr, Rankin JS. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation 1985;71:994-1009.
22. Raff GL, Glantz SA. Volume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart. Circ Res 1981;48:813-824.
23. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002;30:e36.
24. Kajimoto H, Ishigaki K, Okumura K, Tomimatsu H, Nakazawa M, Saito K et al Beta-blocker therapy for cardiac dysfunction in patients with muscular dystrophy. Circ J 2006;70:991-994.
25. Shaddy RE, Boucek MM, Hsu DT, Boucek RJ, Canter CE, Mahony L, Ross RD, Pahl E, Blume ED, Dodd DA, Rosenthal DN, Burr J, LaSalle B, Holubkov R, Lukas MA, Tani LY;, Pediatric Carvedilol Study Group. Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA 2007; 298:1171-1179.
26. Kantor PF, Abraham JR, Dipchand AI, Benson LN, Redington AN. The impact of changing medical therapy on transplantation-free survival in pediatric dilated car-diomyopathy. J Am Coll Cardiol 2010;55:1377-1384.
27. Haber HL, Simek CL, Gimple LW, Bergin JD, Subbiah K, Jayaweera AR, Powers ER, Feldman MD. Why do patients with congestive heart failure tolerate the initiation of beta-blocker therapy? Circulation 1993;88:1610-1619.
28. 2+ transient decline and myocardial relaxation are slowed during low flow ischemia in rat hearts. J Clin Invest 1994;93:951-957.
29. MacGowan GA, Kirk JA, Evans C, Shroff SG. Pressure-calcium relationships in the perfused mouse heart. Am J Physiol Heart Circ Physiol 2006;290: H2614-H2624.
30. Cohn RD, Durbeej M, Moore SA, Coral-Vazquez R, Prouty S, Campbell KP. Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcogly-can-sarcospan complex. J Clin Invest 2001;107:153-154.
31. Lowes BD, Gilbert EM, Abraham WT, Minobe WA, Larrabee P, Ferguson D, Wolfel EE, Lindenfeld J, Tsvetkova T, Robertson AD, Quaife RA, Bristow MR. Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents. N Engl J Med 2002;346:1357-1365.
32. MacGowan GA, Neely D, Peaston R, Wrightson N, Parry G. Evaluation of NT-proBNP to predict outcomes in advanced heart failure. Int J Clin Pract 2010; 64:892-899.