Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans

BMC Research Notes

Volumn 5, Issue , 2012, Pages

  Fischer, Alexandra ^a   Onur, Simone ^a   Schmelzer, Constance ^b   Döring, Frank ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

Coenzyme Q10; DNA methylation; Gene expression; Inflammation; Ubiquinol

Indexed keywords

AUTACOID; CXCL2 CHEMOKINE; CXCL2 PROTEIN, HUMAN; DRUG DERIVATIVE; MESSENGER RNA; UBIQUINOL; UBIQUINONE;

ADULT; ARTICLE; CLINICAL TRIAL; CPG ISLAND; DIET SUPPLEMENTATION; DNA METHYLATION; DOWN REGULATION; DRUG EFFECT; GENETICS; HUMAN; MALE; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; MONOCYTE;

ADULT; CHEMOKINE CXCL2; CPG ISLANDS; DIETARY SUPPLEMENTS; DNA METHYLATION; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; MONOCYTES; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UBIQUINONE; YOUNG ADULT;

MLCS; MLOWN;

EID: 84872161501     PISSN: None     EISSN: 17560500     Source Type: Journal    
DOI: 10.1186/1756-0500-5-540     Document Type: Article

References (43)

1. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Littarru GP, Tiano L, Mol Biotechnol 2007 37 1 31 37 10.1007/s12033-007-0052-y 17914161 (Pubitemid 350135901)
2. Clinical aspects of coenzyme Q10: an update. Littarru GP, Tiano L, Nutrition 2010 26 3 250 254 10.1016/j.nut.2009.08.008 19932599
3. Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution. Mukai K, Itoh S, Morimoto H, J Biol Chem 1992 267 31 22277 22281 1429580
4. The diversity of coenzyme Q function. Crane FL, Navas P, Mol Aspects Med 1997 18 Suppl 1 S6 9266500
5. Identification of LPS-inducible genes downregulated by ubiquinone in human THP-1 monocytes. Schmelzer C, Doring F, Biofactors 2010 36 3 222 228 10.1002/biof.93 20533395
6. The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells. Schmelzer C, Kohl C, Rimbach G, Doring F, J Med Food 2011 14 4 391 397 10.1089/jmf.2010.0080 21370964
7. Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, Littarru GP, Doring F, Int J Biochem Cell Biol 2005 37 6 1208 1218 10.1016/j.biocel.2004.11.017 15778085 (Pubitemid 40381197)
8. Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice. Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaarden I, Doring F, Higuchi K, Mol Nutr Food Res 2010 54 6 805 815 19960455
9. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. Schmelzer C, Niklowitz P, Okun JG, Haas D, Menke T, Doring F, IUBMB Life 2011 63 1 42 48 10.1002/iub.413 21280176
10. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM, Endocrinology 2010 151 10 4756 4764 10.1210/en.2010-0505 20685869
11. Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women. Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuniga O, Delgado-Lista J, Gutierrez-Mariscal FM, Perez-Martinez P, Delgado-Casado N, Cruz-Teno C, Tinahones FJ, Villalba JM, et al. J Gerontol A: Biol Sci Med Sci 2012 67 1 3 10
12. Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas. van den Donk M, van Engeland M, Pellis L, Witteman BJ, Kok FJ, Keijer J, Kampman E, Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 16 2 327 333 10.1158/1055-9965.EPI- 06-0810 23300022 (Pubitemid 46383354)
13. Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. van Engeland M, Weijenberg MP, Roemen GM, Brink M, de Bruine AP, Goldbohm RA, van den Brandt PA, Baylin SB, de Goeij AF, Herman JG, Cancer Res 2003 63 12 3133 3137 12810640 (Pubitemid 36735864)
14. MicroRNAs, epigenetics and disease. Silahtaroglu A, Stenvang J, Essays Biochem 2010 48 1 165 185 10.1042/bse0480165 20822493
15. Epigenetic regulation of mammalian genomic imprinting. Delaval K, Feil R, Curr Opin Genet Dev 2004 14 2 188 195 10.1016/j.gde.2004.01.005 15196466 (Pubitemid 38520147)
16. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Takai D, Jones PA, Proc Natl Acad Sci USA 2002 99 6 3740 3745 10.1073/pnas.052410099 11891299 (Pubitemid 34252176)
17. PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte. Bender AT, Beavo JA, Proc Natl Acad Sci USA 2006 103 2 460 465 10.1073/pnas.0509972102 16407168 (Pubitemid 43122423)
18. Global effects of inorganic arsenic on gene expression profile in human macrophages. Bourdonnay E, Morzadec C, Sparfel L, Galibert MD, Jouneau S, Martin-Chouly C, Fardel O, Vernhet L, Mol Immunol 2009 46 4 649 656 10.1016/j.molimm.2008.08.268 19128835
19. Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments. Liang F, Seyrantepe V, Landry K, Ahmad R, Ahmad A, Stamatos NM, Pshezhetsky AV, J Biol Chem 2006 281 37 27526 27538 10.1074/jbc.M605633200 16835219 (Pubitemid 44401779)
20. Monocyte to macrophage differentiation-associated (MMD) positively regulates ERK and Akt activation and TNF-alpha and NO production in macrophages. Liu Q, Zheng J, Yin DD, Xiang J, He F, Wang YC, Liang L, Qin HY, Liu L, Liang YM, Han H, Mol Biol Rep 2012 39 5 5643 5650 10.1007/s11033-011-1370-5 22203480
21. The transcriptional targets of p53 in apoptosis control. Yu J, Zhang L, Biochem Biophys Res Commun 2005 331 3 851 858 10.1016/j.bbrc.2005.03.189 15865941 (Pubitemid 40615516)
22. Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)- prostaglandin J(2) in mouse peritoneal macrophages. Kim HY, Kim HS, Immunol Cell Biol 2007 85 1 60 67 10.1038/sj.icb.7100001 17130903 (Pubitemid 46067323)
23. Bestatin, an inhibitor for aminopeptidases, modulates the production of cytokines and chemokines by activated monocytes and macrophages. Lkhagvaa B, Tani K, Sato K, Toyoda Y, Suzuka C, Sone S, Cytokine 2008 44 3 386 391 10.1016/j.cyto.2008.10.011 19036603
24. Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains. Rehli M, Krause SW, Schwarzfischer L, Kreutz M, Andreesen R, Biochem Biophys Res Commun 1995 217 2 661 667 10.1006/bbrc.1995.2825 7503749 (Pubitemid 26011760)
25. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP, PLoS Genet 2007 3 10 2023 2036 17967063
26. Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. Premkumar VG, Yuvaraj S, Shanthi P, Sachdanandam P, Br J Nutr 2008 100 6 1179 1182 10.1017/S0007114508968276 18377693
27. Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver. Brunaud L, Alberto JM, Ayav A, Gerard P, Namour F, Antunes L, Braun M, Bronowicki JP, Bresler L, Gueant JL, Clin Chem Lab Med: CCLM / FESCC 2003 41 8 1012 1019 (Pubitemid 37069199)
28. Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver. Fischer A, Gaedicke S, Frank J, Doring F, Rimbach G, Br J Nutr 2010 104 7 935 940 10.1017/S0007114510001649 20447326
29. Folate and DNA Methylation. Ly A, Hoyt L, Crowell J, Kim YI, Antioxid Redox Signal 2012
30. Change of epigenetic control of cystathionine beta-synthase gene expression through dietary vitamin B12 is not recovered by methionine supplementation. Uekawa A, Katsushima K, Ogata A, Kawata T, Maeda N, Kobayashi K, Maekawa A, Tadokoro T, Yamamoto Y, J Nutrigenet Nutrigenomics 2009 2 1 29 36 10.1159/000165374 19776636
31. Assessing the effects of high methionine intake on DNA methylation. Waterland RA, J Nutr 2006 136 6 Suppl 1706S 1710S 16702343 (Pubitemid 43765384)
32. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. Wolff GL, Kodell RL, Moore SR, Cooney CA, FASEB J: Off Publ Fed Am Soc Exp Biol 1998 12 11 949 957 (Pubitemid 28359576)
33. The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. Schmelzer C, Okun JG, Haas D, Higuchi K, Sawashita J, Mori M, Doring F, IUBMB Life 2010 62 11 812 818 10.1002/iub.388 21086475
34. Expression of various genes is controlled by DNA methylation during mammalian development. Ehrlich M, J Cell Biochem 2003 88 5 899 910 10.1002/jcb.10464 12616529 (Pubitemid 36337034)
35. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. De Smet C, Lurquin C, Lethe B, Martelange V, Boon T, Mol Cell Biol 1999 19 11 7327 7335 10523621 (Pubitemid 29493396)
36. The 5-methylcytosine content of DNA from human tumors. Gama-Sosa MA, Slagel VA, Trewyn RW, Oxenhandler R, Kuo KC, Gehrke CW, Ehrlich M, Nucleic Acids Res 1983 11 19 6883 6894 10.1093/nar/11.19.6883 6314264
37. Alterations in DNA methylation: a fundamental aspect of neoplasia. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP, Adv Cancer Res 1998 72 141 196 9338076 (Pubitemid 27435555)
38. Effects of ubiquinol-10 on microRNA-146a expression in vitro and in vivo. Schmelzer C, Kitano M, Rimbach G, Niklowitz P, Menke T, Hosoe K, Doring F, Mediators Inflamm 2009 2009 415437 19390647
39. Functions of coenzyme Q10 in inflammation and gene expression. Schmelzer C, Lindner I, Rimbach G, Niklowitz P, Menke T, Doring F, Biofactors 2008 32 1-4 179 183 19096114
40. Functional connections and pathways of coenzyme Q10-inducible genes: an in-silico study. Schmelzer C, Lindner I, Vock C, Fujii K, Doring F, IUBMB Life 2007 59 10 628 633 10.1080/15216540701545991 17852568 (Pubitemid 47463914)
41. Effects of Coenzyme Q10 on TNF-alpha secretion in human and murine monocytic cell lines. Schmelzer C, Lorenz G, Lindner I, Rimbach G, Niklowitz P, Menke T, Doring F, Biofactors 2007 31 1 35 41 10.1002/biof.5520310104 18806307 (Pubitemid 352032104)
42. Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation. Dominguez PM, Ardavin C, Immunol Rev 2010 234 1 90 104 10.1111/j.0105-2896.2009.00876.x 20193014
43. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, Menke T, Cani PD, Delzenne NM, Biochem Pharmacol 2009 78 11 1391 1400 10.1016/j.bcp.2009.07.008 19632207