P22 viral capsids as nanocomposite high-relaxivity MRI contrast agents

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 11-17

  Qazi, Shefah ^a   Liepold, Lars O ^a   Abedin, Md Joynal ^a   Johnson, Ben ^a   Prevelige, Peter ^b   Frank, Joseph A ^c,d   Douglas, Trevor ^a  

^a MONTANA STATE UNIVERSITY   (United States)

^b University of Alabama at Birmingham   (United States)

^c CLINICAL CENTER   (United States)

^d NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

azide alkyne click chemistry; bacteriophage P22; contrast agent; DTPA Gd; gadolinium; imaging agent; magnetic resonance imaging; MRI; nanocomposite; nanoparticle; payload; protein cages; relaxivity; T1; viral capsid; VLP

Indexed keywords

GADOLINIUM; NANOCOMPOSITE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; OLIGOMER; PENTETIC ACID;

ARTICLE; BACTERIOPHAGE P22; CONTROLLED STUDY; CORRELATIONAL STUDY; MORPHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN MODIFICATION; TRANSLATION REGULATION; VIRUS CAPSID;

BACTERIOPHAGE P22; CAPSID; CONTRAST MEDIA; GADOLINIUM; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING; NANOCOMPOSITES;

EID: 84872158522     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300208g     Document Type: Article

References (36)

1. Caravan, P. Strategies for increasing the sensitivity of gadolinium based MRI contrast agents Chem. Soc. Rev. 2006, 35 (6) 512-523
2. Cormode, D. P.; Jarzyna, P. A.; Mulder, W. J. M.; Fayad, Z. A. Modified natural nanoparticles as contrast agents for medical imaging Adv. Drug Delivery Rev. 2010, 62 (3) 329-338
3. Bumb, A.; Brechbiel, M.; Choyke, P. Macromolecular and dendrimer-based magnetic resonance contrast agents Acta Radiol. 2010, 51, 751-767
4. Kamaly, N.; Miller, A. Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging Int. J. Mol. Sci. 2010, 11, 1759-1776
5. Mulder, W.; Strijkers, G.; van Tilborg, G.; Griffioen, A.; Nicolay, K. Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging NMR Biomed. 2006, 19 (1) 142-164
6. Liepold, L.; Abedin, M.; Buckhouse, E.; Frank, J.; Young, M.; Douglas, T. Supramolecular Protein Cage Composite MR Contrast Agents with Extremely Efficient Relaxivity Properties Nano Lett. 2009, 9 (12) 4520-4526
7. Abedin, M.; Liepold, L.; Suci, P.; Young, M.; Douglas, T. Synthesis of a Cross-Linked Branched Polymer Network in the Interior of a Protein Cage J. Am. Chem. Soc. 2009, 131 (12) 4346-4354
8. Ferreira, M. F.; Mousavi, B.; Ferreira, P. M.; Martins, C. I. O.; Helm, L.; Martins, J. A.; Geraldes, C. F. G. C. Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI Dalton Trans. 2012, 41 (18) 5472-5475
9. Allen, M.; Bulte, J.; Liepold, L.; Basu, G.; Zywicke, H.; Frank, J.; Young, M.; Douglas, T. Paramagnetic viral nanoparticles as potential high-relaxivity magnetic resonance contrast agents Magn. Reson. Med. 2005, 54 (4) 807-812
10. Anderson, E.; Isaacman, S.; Peabody, D.; Wang, E.; Canary, J.; Kirshenbaum, K. Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid Nano Lett. 2006, 6 (6) 1160-1164
11. Datta, A.; Hooker, J.; Botta, M.; Francis, M.; Aime, S.; Raymond, K. High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: Nanosized MRI contrast agents J. Am. Chem. Soc. 2008, 130 (8) 2546-2552
12. Hooker, J.; Datta, A.; Botta, M.; Raymond, K.; Francis, M. Magnetic resonance contrast agents from viral capsid shells: A comparison of exterior and interior cargo strategies Nano Lett. 2007, 7 (8) 2207-2210
13. Liepold, L.; Anderson, S.; Willits, D.; Oltrogge, L.; Frank, J.; Douglas, T.; Young, M. Viral capsids as MRI contrast agents Magn. Reson. Med. 2007, 58 (5) 871-879
14. Pokorski, J.; Breitenkamp, K.; Liepold, L.; Qazi, S.; Finn, M. G. Functional Virus-Based Polymer-Protein Nanoparticles by Atom Transfer Radical Polymerization J. Am. Chem. Soc. 2011, 133 (24) 9242-9245
15. Prasuhn, D.; Yeh, R.; Obenaus, A.; Manchester, M.; Finn, M. G.; Viral, M. R. I. contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition Chem. Commun. 2007, 12, 1269-1271
16. Steinmetz, N. F. Viral nanoparticles as platforms for next-generation therapeutics and imaging devices Nanomedicine 2010, 6 (5) 634-641
17. Earnshaw, W.; Casjens, S.; Harrison, S. Assembly of head of bacterophage P22-X-ray difrraction from heads, proheads and related structures J. Mol. Biol. 1976, 104 (2) 387-410
18. King, J.; Lenk, E.; Botstein, D. Mechanism of head assembly and DNA encapsulation in Salmonella phage P22. II. Morphogenetic pathway J. Mol. Biol. 1973, 80 (4) 697-731
19. Prevelige, P.; Thomas, D.; King, J. Scaffolding protein regulates the polymerization of P22 coat subunits into icosahedral shells in vitro J. Mol. Biol. 1988, 202 (4) 743-757
20. Aime, S.; Cabella, C.; Colombatto, S.; Crich, S.; Gianolio, E.; Maggioni, F. Insights into the use of paramagnetic Gd (III) complexes in MR-molecular imaging investigations J. Magn. Reson. Imaging 2002, 16 (4) 394-406
21. Kang, S.; Uchida, M.; O'Neil, A.; Li, R.; Prevelige, P.; Douglas, T. Implementation of P22 Viral Capsids as Nanoplatforms Biomacromolecules 2010, 11 (10) 2804-2809
22. Teschke, C.; McGough, A.; Thuman-Commike, P. Penton release from P22 heat-expanded capsids suggests importance of stabilizing penton-hexon interactions during capsid maturation Biophys. J. 2003, 84 (4) 2585-2592
23. Kang, S.; Hawkridge, A.; Johnson, K.; Muddiman, D.; Prevelige, P. Identification of Subunit-Subunit Interactions in Bacteriophage P22 Procapsids by Chemical Cross-linking and Mass Spectrometry J. Proteome Res. 2006, 5 (2) 370-377
24. Gupta, S.; Kuzelka, J.; Singh, P.; Lewis, W.; Manchester, M.; Finn, M. G. Accelerated Bioorthogonal Conjugation: A Practical Method for the Ligation of Diverse Functional Molecules to a Polyvalent Virus Scaffold Bioconjugate Chem. 2005, 16 (6) 1572-1579
25. Hong, V.; Presolski, S.; Ma, C.; Finn, M. G. Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation Angew. Chem., Int. Ed. 2009, 48 (52) 9879-9883
26. Crich, S.; Biancone, L.; Cantaluppi, V.; Esposito, D.; Russo, S.; Camussi, G.; Aime, S. Improved route for the visualization of stem cells labeled with a Gd-/Eu-chelate as dual (MRI and fluorescence) agent Magn. Reson. Med. 2004, 51 (5) 938-944
27. Bidlingmeyer, B. A.; Cohen, S. A.; Tarvin, T. L. Rapid analysis of amino acids using pre-column derivatization J. Chromatogr., B: Biomed. Sci. Appl. 1984, 336 (1) 93-104
28. Jiang, W.; Li, Z.; Zhang, Z.; Baker, M.; Prevelige, P.; Chiu, W. Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions Nat. Struct. Biol. 2003, 10 (2) 131-135
29. Parent, K.; Khayat, R.; Tu, L.; Suhanovsky, M.; Cortines, J.; Teschke, C.; Johnson, J.; Baker, T. P22 Coat Protein Structures Reveal a Novel Mechanism for Capsid Maturation: Stability without Auxiliary Proteins or Chemical Crosslinks Structure 2010, 18 (3) 390-401
30. Lauffer, R. Paramagnetic Metal-Complexes as Water Proton Relaxation Agents for Nmr Imaging-Theory and Design Chem. Rev. 1987, 87 (5) 901-927
31. 3+ Complexes of Interest in Magnetic Resonance Imaging: An Integrated and Theoretically Self-Consistent Approach J. Am. Chem. Soc. 1996, 118 (39) 9333-9346
32. Helm, L. Relaxivity in paramagnetic systems: Theory and mechanisms Prog. Nucl. Magn. Reson. Spectrosc. 2006, 49 (1) 45-64
33. Helm, L.; Merbach, A. Inorganic and bioinorganic solvent exchange mechanisms Chem. Rev. 2005, 105 (6) 1923-1959
34. Helm, L.; Nicolle, G. L. M.; Merbach, R. E. Water and Proton Exchange Processes on Metal Ions Adv. Inorg. Chem. 2005, 57, 327-379
35. Garimella, P. D.; Datta, A.; Romanini, D. W.; Raymond, K. N.; Francis, M. B. Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes J. Am. Chem. Soc. 2011, 133 (37) 14704-14709
36. Na, H. B.; Song, I. C.; Hyeon, T. Inorganic Nanoparticles for MRI Contrast Agents Adv. Mater. 2009, 21 (21) 2133-2148