Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as CCR5 Antagonists

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Liu, Tao ^a   Weng, Zhiyong ^a,e   Dong, Xiaowu ^a   Chen, Linjie ^b   Ma, Ling ^c,d   Cen, Shan ^c,d   Zhou, Naiming ^b   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^d PEKING UNION MEDICAL COLLEGE   (China)

^e Hangzhou No 2 High School   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL N [3 [4 (4 CARBAMOYLBENZYL) 1 PIPERIDINYL]PROPYL] N (3 CHLORO 4 METHYLPHENYL) 4 PIPERIDINECARBOXAMIDE; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; MARAVIROC; PIPERAZINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IC 50; NONHUMAN; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; ANTIGENS, CD4; BIOLOGICAL ASSAY; CELL FUSION; CELL SURVIVAL; DRUG DESIGN; GENE EXPRESSION; GENES, REPORTER; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; LUCIFERASES; PIPERAZINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84872156428     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053636     Document Type: Article

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