Effects of propofol on PBK/Akt signaling pathway and endoplasmic reticulum stress pathway of apoptosis induced by ischemia-reperfusion in isolated rat hearts

National Medical Journal of China

Volumn 92, Issue 37, 2012, Pages 2611-2614

  Liu, Liu ^a   Pang, Yong ^a   He, Dong Wei ^a   Liu, Xin Wei ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Endoplasmic reticulum stress; PI3K Akt; Propofol

Indexed keywords

CASPASE 12; PROPOFOL; PROTEIN KINASE B; WORTMANNIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HEART FUNCTION; IMMUNOHISTOCHEMISTRY; ISCHEMIC POSTCONDITIONING; ISCHEMIC PRECONDITIONING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; HEART; IN VITRO STUDY; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; ENDOPLASMIC RETICULUM STRESS; HEART; MALE; PHOSPHATIDYLINOSITOL 3-KINASES; PROPOFOL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84872145346     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2012.37.006     Document Type: Article

References (17)

1. Baines C P. How and when do myocytes die during ischemia and reperfusion: the late phase. J Cardiovasc Pharmacol Ther, 2011, 16: 239-243.
2. Zhang G G, Teng X, Liu Y, et al. Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart. Peptides, 2009, 30: 1109-1116.
3. Jin Y C, Kim W, Ha Y M, et al. Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo. Vascul Pharmacol, 2009, 50: 71-77.
4. He W, Zhang F J, Wang S P, et al. Postconditioning of sevoflurane and propofol is associated with mitochondrial permeability transition pore. J Zhejiang Univ Sci B, 2008, 9: 100-108.
5. Shao H, Li J, Zhou Y, et al. Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic/reperfused rat heart; role of cardiolipin. Br J Pharmacol, 2008, 153: 1641-1649.
6. Sun H Y, Xue F S, Xu Y C, et al. Propofol improves cardiac functional recovery after ischemia-reperfusion by upregulating nitric oxide synthase activity in the isolated rat hearts. Chin Med J, 2009, 122: 3048-3054.
7. 2003, 23: 750-753.
8. Frässdorf J, De Hert S, Schlack W. Anesthesia and myocardial ischemia/reperfusion injury. Br J Anesth, 2009, 103: 89-98.
9. Minamino T, Kitakaze M. ER stress in cardiovascular disease. J Mol Cell Cardiol, 2010, 4: 1105-1110.
10. McCullough K D, Martindale J L, Klotz L O, et al. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol, 2001, 21: 1249-1259.
11. Takashi M, Anthony R. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol, 2005, 38: 63-71.
12. 2009, 89: 54-58.
13. Wang B, Shravah J, Luo H, et al. Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation. Biochern Biophys Res Commun, 2009, 389: 105-111.
14. Hu P, Han Z, Couvillon A D, et al. Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death. J Biol Chem, 2004, 279: 49420-49429.
15. Tao J, Zhu W, Li Y, et al. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion. Am J Physiol Heart Circ Physiol, 2011, 301: H1471-1486.
16. Yu L N, Yu J, Zhang F J, et al. Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins. J Zhejiang Univ Sci B, 2010, 11: 661-672.
17. Schreckenberg R, Maier T, Schlüter K D. Post-conditioning restores pre-ischaemic receptor coupling in rat isolated hearts. Br J Pharmacol, 2009, 156: 901-908.