Development of porous silicon nanocarriers for parenteral peptide delivery

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 353-359

  Kovalainen, Miia ^a   Mönkäre, Juha ^a   Kaasalainen, Martti ^b   Riikonen, Joakim ^a   Lehto, Vesa Pekka ^a   Salonen, Jarno ^b   Herzig, Karl Heinz ^c,d   Järvinen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

intravenous; mesoporous; porous silicon nanocarriers; PYY3 36; subcutaneous; sustained release

Indexed keywords

10 UNDECENOIC ACID; HYDROCARBON; NANOCARRIER; PEPTIDE YY [3-36]; POROUS SILICON; SILICON; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; FEASIBILITY STUDY; HYDROPHILICITY; NANOFABRICATION; POROSITY; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; THERMAL DIFFUSION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, INTRAVENOUS; ANIMALS; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; MICE; MICE, INBRED BALB C; NANOPARTICLES; PEPTIDE FRAGMENTS; PEPTIDE YY; POROSITY; SILICON;

EID: 84872140096     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300494p     Document Type: Article

References (31)

1. Malam, Y.; Lim, E. J.; Seifalian, A. M. Current Trends in the Application of Nanoparticles in Drug Delivery Curr. Med. Chem. 2011, 18, 71067-71078
2. Pandey, R.; Khuller, G. K. Subcutaneous nanoparticle-based antitubercular chemotherapy in an experimental model J. Antimicrob. Chemother. 2004, 54, 1266-1268
3. Chan, Y. P.; Meyrueix, R.; Kravtzoff, R.; Nicolas, F.; Lundstrom, K. Review on Medusa:a polymer-based sustained release technology for protein and peptide drugs Expert Opin. Drug Delivery 2007, 4, 4441-4451
4. Park, J. H.; Gu, L.; von Maltzahn, G.; Ruoslahti, E.; Bhatia, S. N. Sailor, M.J. Biodegradable luminescent porous silicon nanoparticles for in vivo applications Nat. Mater. 2009, 8, 4331-4336
5. Bimbo, L. M.; Mäkilä, E.; Laaksonen, T.; Lehto, V. P.; Salonen, J.; Hirvonen, J.; Santos, H. A. Drug permeation across intestinal epithelial cells using porous silicon nanoparticles Biomaterials 2011, 32, 102625-102633
6. Tasciotti, E.; Liu, X.; Bhavane, R.; Plant, K.; Leonard, A. D.; Price, B. K.; Cheng, M. M.; Decuzzi, P.; Tour, J. M.; Robertson, F.; Ferrari, M. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications Nat. Nanotechnol. 2008, 3, 3151-3157
7. Tanaka, T.; Godin, B.; Bhavane, R.; Nieves-Alicea, R.; Gu, J.; Liu, X.; Chiappini, C.; Fakhoury, J. R.; Amra, S.; Ewing, A.; Li, Q.; Fidler, I. J.; Ferrari, M. In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice Int. J. Pharm. 2010, 402, 190-197
8. Bimbo, L. M.; Sarparanta, M.; Santos, H. A.; Airaksinen, A. J.; Mäkilä, E.; Laaksonen, T.; Peltonen, L.; Lehto, V. P.; Hirvonen, J.; Salonen, J. Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats ACS Nano 2010, 4, 63023-63032
9. Hong, C.; Lee, J.; Son, M.; Hong, S. S.; Lee, C. In-vivo cancer cell destruction using porous silicon nanoparticles Anticancer Drugs 2011, 22, 10971-10977
10. Limnell, T.; Riikonen, J.; Salonen, J.; Kaukonen, A. M.; Laitinen, L.; Hirvonen, J.; Lehto, V. P. Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles Int. J. Pharm. 2007, 343, 141-147
11. Jarvis, K. L.; Barnes, T. J.; Prestidge, C. A. Surface chemical modification to control molecular interactions with porous silicon J. Colloid Interface Sci. 2011, 363, 1327-1333
12. Santos, H. A.; Riikonen, J.; Salonen, J.; Mäkilä, E.; Heikkilä, T.; Laaksonen, T.; Peltonen, L.; Lehto, V. P.; Hirvonen, J. In vitro cytotoxicity of porous silicon microparticles: Effect of the particle concentration, surface chemistry and size Acta Biomater. 2010, 6, 72721-72731
13. Kilpeläinen, M.; Riikonen, J.; Vlasova, M. A.; Huotari, A.; Lehto, V. P.; Salonen, J.; Herzig, K. H.; Järvinen, K. In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles J. Controlled Release 2009, 137, 2166-2170
14. Wang, F.; Hui, H.; Barnes, T. J.; Barnett, C.; Prestidge, C. A. Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs Mol. Pharmaceutics 2010, 7, 1227-1236
15. Wu, E. C.; Park, J. H.; Park, J.; Segal, E.; Cunin, F. Sailor, M.J. Oxidation-triggered release of fluorescent molecules or drugs from mesoporous Si microparticles ACS Nano 2008, 2, 112401-112409
16. Vlieghe, P.; Lisowski, V.; Martinez, J.; Khrestchatisky, M. Synthetic therapeutic peptides: science and market Drug Discovery Today 2010, 15, 40-56
17. Karhunen, L. J.; Juvonen, K. R.; Huotari, A.; Purhonen, A. K.; Herzig, K. H. Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans Regul. Pept. 2008, 149, 70-78
18. Tatemoto, K.; Mutt, V. Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides Nature 1980, 285, 417-418
19. Chandarana, K.; Batterham, R. Peptide YY Curr. Opin. Endocrinol. Diabetes Obes. 2008, 15, 165-172
20. Karra, E.; Chandarana, K.; Batterham, R. L. The role of peptide YY in appetite regulation and obesity J. Physiol. 2009, 587, 119-125
21. Sloth, B.; Davidsen, L.; Holst, J. J.; Flint, A.; Astrup, A. Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males Am. J. Physiol. Endocrinol. Metab. 2007, 293, E604-E609
22. Gantz, I.; Erondu, N.; Mallick, M.; Musser, B.; Krishna, R.; Tanaka, W. K.; Snyder, K.; Stevens, C.; Stroh, M. A.; Zhu, H.; Wagner, J. A.; Macneil, D. J.; Heymsfield, S. B.; Amatruda, J. M. Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults J. Clin. Endocrinol. Metab. 2007, 92, 51754-51757
23. Beglinger, C.; Poller, B.; Arbit, E.; Ganzoni, C.; Gass, S.; Gomez-Orellana, I.; Drewe, J. Pharmacokinetics and pharmacodynamic effects of oral GLP-1 and PYY3-36: a proof-of-concept study in healthy subjects Clin. Pharmacol. Ther. 2008, 84, 4468-4474
24. Kovalainen, M.; Mönkäre, J.; Mäkilä, E.; Salonen, J.; Lehto, V. P.; Herzig, K. H.; Järvinen, K. Mesoporous silicon (PSi) for sustained peptide delivery: effect of PSi microparticle surface chemistry on Peptide YY3-36 release Pharm. Res. 2012, 29, 3837-3846
25. Boukherroub, R.; Wojtyk, J.; Wayner, D.; Lockwood, D. Thermal hydrosilylation of undecylenic acid with porous silicon J. Electrochem. Soc. 2002, 149, H59-H63
26. Alexis, F.; Pridgen, E.; Molnar, L. K.; Farokhzad, O. C. Factors affecting the clearance and biodistribution of polymeric nanoparticles Mol. Pharmaceutics 2008, 5, 4505-4515
27. Decuzzi, P.; Godin, B.; Tanaka, T.; Lee, S. Y.; Chiappini, C.; Liu, X.; Ferrari, M. Size and shape effects in the biodistribution of intravascularly injected particles J. Controlled Release 2010, 141, 3320-3327
28. Tanaka, T.; Mangala, L. S.; Vivas-Mejia, P. E.; Nieves-Alicea, R.; Mann, A. P.; Mora, E.; Han, H. D.; Shahzad, M. M.; Liu, X.; Bhavane, R.; Gu, J.; Fakhoury, J. R.; Chiappini, C.; Lu, C.; Matsuo, K.; Godin, B.; Stone, R. L.; Nick, A. M.; Lopez-Berestein, G.; Sood, A. K.; Ferrari, M. Sustained small interfering RNA delivery by mesoporous silicon particles Cancer Res. 2010, 70, 93687-93696
29. Kilpeläinen, M.; Mönkäre, J.; Vlasova, M. A.; Riikonen, J.; Lehto, V. P.; Salonen, J.; Järvinen, K.; Herzig, K. H. Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery Eur. J. Pharm. Biopharm. 2011, 77, 120-125
30. Huhtala, T.; Rytkönen, J.; Jalanko, A.; Kaasalainen, M.; Salonen, J.; Riikonen, R.; Närvänen, A. Native and Complexed IGF-1: Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis J. Drug Delivery 2012, 2012, 626417
31. Godin, B.; Gu, J.; Serda, R. E.; Bhavane, R.; Tasciotti, E.; Chiappini, C.; Liu, X.; Tanaka, T.; Decuzzi, P.; Ferrari, M. Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation J. Biomed. Mater. Res. Part A 2010, 94A, 41236-41243