Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism

Xenobiotica

Volumn 43, Issue 2, 2013, Pages 211-218

  Pan, Wei ^a,b   Bae, Soo Kyung ^a,c   Shim, Eon Jeong ^a,c   Park, Sung Eun ^a   Lee, Sang Seop ^a   Park, Soo Jin ^a,c   Yeo, Chang Woo ^a,c   Zhou, Hong Hao ^b   Shon, Ji Hong ^a,c   Shin, Jae Gook ^a,c  

^a Inje University College of Medicine   (South Korea)

^b Central South University   (China)

^c Inje University College of Medicine   (South Korea)

Author keywords

Clarithromycin; Clopidogrel; CYP2B6 genotype; Drug interaction; Sibutramine and active metabolites

Indexed keywords

CLARITHROMYCIN; CLOPIDOGREL; CYTOCHROME P450 2B6; DIDESMETHYL SIBUTRAMINE; DRUG METABOLITE; MONODESMETHYL SIBUTRAMINE; SIBUTRAMINE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXPOSURE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IN VIVO STUDY; KOREA; MALE; NORMAL HUMAN; OPEN STUDY; PHASE 3 CLINICAL TRIAL; SINGLE DRUG DOSE; UNSPECIFIED SIDE EFFECT;

ANTI-BACTERIAL AGENTS; APPETITE DEPRESSANTS; ARYL HYDROCARBON HYDROXYLASES; ASIAN CONTINENTAL ANCESTRY GROUP; CLARITHROMYCIN; CYCLOBUTANES; HUMANS; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; PLATELET AGGREGATION INHIBITORS; POLYMORPHISM, GENETIC; REPUBLIC OF KOREA; TICLOPIDINE;

EID: 84872138063     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.706722     Document Type: Article

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