Effects of a voltage sensitive calcium channel blocker and a sodium-calcium exchanger inhibitor on apoptosis of motor neurons in adult spinal cord slices

Cell Journal

Volumn 14, Issue 3, 2012, Pages 171-176

  Momeni, Hamid Reza ^a   Jarahzadeh, Mahsa ^a  

^a ARAK UNIVERSITY   (Iran)

Author keywords

Apoptosis; Bepridil; Loperamide; Motor neuron; Spinal Cord

Indexed keywords

BEPRIDIL; CALCIUM CHANNEL; LOPERAMIDE; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; VOLTAGE SENSITIVE CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; EXPERIMENTAL STUDY; FEMALE; MOTONEURON; MOUSE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; SPINAL CORD VENTRAL HORN; TISSUE CULTURE;

EID: 84872110332     PISSN: 22285806     EISSN: 22285814     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Kristian T, Siesjo BK. Calcium in ischemic cell death. Stroke.1998; 29(3): 705-718.
2. Stys PK, Waxman SG, Ransom BR. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. J Neurosci.1992;12(2): 430-439.
3. Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma. 2004; 21(6): 754-774.
4. Bano D, Nicotera P. Ca2+ signals and neuronal death in brain ischemia. Stroke. 2007; 38 Suppl 2: 674-676.
5. Oyinbo CA. Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade. Acta Neurobiol Exp (Wars). 2011; 71(2): 281-299.
6. Xie YF, Macdonald JF, Jackson MF. TRPM2, calcium and neurodegenerative diseases. Int J Physiol Pathophysiol Pharmacol.2010; 2(2): 95-103.
7. Burek CJ, Burek M, Roth J, Los M. Calcium induces apoptosis and necrosis in hematopoetic malignant cells: Evidence for caspase-8 dependent FADD-autonomous pathway. Gene Ther Mol Biol. 2003; 7: 173.
8. Mattson MP, Chan SL. Calcium orchestrates apoptosis. Nat Cell Biol. 2003; 5(12): 1041-1043.
9. Ning ZQ, Murphy JJ. Calcium ionophore-induced apoptosis of human B cells is preceded by the induced expression of early response genes. Eur J Immunol.1993; 23(12): 3369-3372.
10. Sasamura S, Furukawa K, Shiratori M, Motomura S, Ohizumi Y. Antisense-inhibition of plasma membrane Ca2+ pump induces apoptosis in vascular smooth muscle cells. Jpn J Pharmacol. 2002; 90(2): 164-172.
11. Koray AK, Tekeli A, Isbir S. Apoptosis in ischemic spinal cord injury. J Thorac Cardiovasc Surg. 2006; 131(5): 1212-1213.
12. Martin LJ, Price AC, Kaiser A, Shaikh AY, Liu Z. Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review). Int J Mol Med. 2000; 5(1): 3-13.
13. Momeni HR, Kanje M. The calpain inhibitor VI prevents apoptosis of adult motor neurons. Neuroreport. 2005; 16(10): 1065-1068.
14. Momeni HR, Kanje M. Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neu rons. Neuroreport. 2006;17(8): 761-765.
15. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol.2000;1(2): 120-129.
16. Yagami T, Ueda K, Sakaeda T, Itoh N, Sakaguchi G, Okamura N, et al. Protective effects of a selective L-type voltage-sensitive calcium channel blocker, S-312-d, on neuronal cell death. Biochem Pharmacol. 2004; 67(6): 1153-1165.
17. Nashida T, Takuma K, Fukuda S, Kawasaki T, Takahashi T, Baba A, et al. The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011; 59(1): 51-58.
18. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods. 1986; 89(2): 271-277.
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2): 55-63.
20. Liu Y, Peterson DA, Kimura H, Schubert D. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. J Neurochem. 1997; 69(2): 581-593.
21. Connelly CA, Chen LC, Colquhoun SD. Metabolic activity of cultured rat brainstem, hippocampal and spinal cord slices. J Neurosci Methods. 2000; 99(1-2): 1-7.
22. Murakami M, Nakagawasai O, Suzuki T, MobarakehII, Sakurada Y, Murata A, et al. Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. Brain Res. 2004; 1024(1-2): 122-129.
23. Zawadzki A, Liu Q, Wang Y, Melander A, Jeppsson B, Thorlacius H. Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells. Dis Colon Rectum. 2008; 51(11): 1696-1702.
24. Kaya Dagistanli F, Susleyici Duman B, Ozturk M. Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats. Acta Histochem. 2005;107(3): 207-214.
25. Smaili SS, Hsu YT, Carvalho AC, Rosenstock TR, Sharpe JC, Youle RJ. Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Braz J Med Biol Res. 2003; 36(2): 183-190.
26. Jeong SY, Seol DW. The role of mitochondria in apoptosis. BMB Rep. 2008; 41(1): 11-22.
27. Li S, Stys PK. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter. J Neurosci. 2000; 20(3): 1190-1198.