Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and in Silico ADMET screening

Archives of Pharmacal Research

Volumn 35, Issue 10, 2012, Pages 1713-1722

  De Oliveira, Kely N ^a   Souza, Márcia M ^c   Sathler, Plínio Cunha ^b   Magalhães, Uiaran O ^d   Rodrigues, Carlos R ^d   Castro, Helena C ^b   Palm, Patrícia R ^e   Sarda, Maicon ^e   Perotto, Pablo E ^e   Cezar, Sabrina ^e   De Brito, Monique A ^b   Ferreira, Ariane S S R ^b   Cabral, Lúcio Mendes ^d   MacHado, Clodoaldo ^b   Nunes, Ricardo J ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^e REGIONAL UNIVERSITY OF BLUMENAU   (Brazil)

Author keywords

ADMET; Analgesic activity; SAR; Sulphonamides; Sulphonylhydrazones

Indexed keywords

ACETYLSALICYLIC ACID; ANTINOCICEPTIVE AGENT; BENZENE DERIVATIVE; HYDRAZONE DERIVATIVE; IMIDE; PARACETAMOL; SULFONAMIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; MOLECULAR MODEL; MOUSE; NONHUMAN; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; WRITHING TEST;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DRUG DESIGN; HYDRAZONES; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMIDES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PAIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84872099831     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-1002-1     Document Type: Article

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