Synthesis and antinociceptive profile of novel acidic sulphonylhydrazone derivatives from natural safrole

Pharmacy and Pharmacology Communications

Volumn 5, Issue 12, 1999, Pages 673-678

  Lima, Lídia M ^a   Amarante, Emanuel G ^a   Miranda, Ana L P ^a   Fraga, Carlos A M ^a   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; HYDRAZONE DERIVATIVE; PHENYL GROUP; SAFROLE;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG POTENCY; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; MELTING POINT; NOCICEPTION; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0033370394     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080899128734370     Document Type: Article

References (4)

1. Eh, M., Schomburg, D., Schicht, K., Kalesse, M. (1995) An efficient synthesis of radicinin analogues. Tetrahedron 51: 8983-8992
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3. Lima, P. C., Lima, L. M., Leda, P. H. O., Miranda, A. L. P., Fraga, C. A. M., Barreiro, E. J. (1999) Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole. Eur. J. Med. Chem. 34: In press
4. Whittle, B. A. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and non narcotic analgesics. Br. J. Pharmacol. 22: 246-253