The human W42R γD-crystallin mutant structure provides a link between congenital and age-related cataracts

Journal of Biological Chemistry

Volumn 288, Issue 1, 2013, Pages 99-109

  Ji, Fangling ^a,b   Jungs, Jinwon ^b   Koharudin, Leonardus M I ^b   Gronenborn, Angela M ^b  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED; AUTOSOMAL DOMINANTS; CATARACT FORMATION; CHEMICAL EXCHANGE; CONGENITAL CATARACT; HYDROGEN/DEUTERIUM EXCHANGE; MOLECULAR MECHANISM; MUTANT PROTEINS; N-TERMINAL DOMAINS; PROTEASE DIGESTION; PROTEOLYTIC SUSCEPTIBILITY; SMALL POPULATION; UNFOLDED PROTEINS; WILD TYPES;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

CRYSTAL STRUCTURE;

GAMMA CRYSTALLIN; GAMMA D CRYSTALLIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CONGENITAL CATARACT; CONTROLLED STUDY; CRYSTAL STRUCTURE; MUTANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN UNFOLDING; SENILE CATARACT; ULTRAVIOLET RADIATION; WILD TYPE;

BIOPHYSICS; CATARACT; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-CRYSTALLINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPSIN;

EID: 84872057460     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.416354     Document Type: Article

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