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Volumn 288, Issue 1, 2013, Pages 79-88

Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of smad proteins

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; PHOSPHATASES; SIGNAL TRANSDUCTION;

EID: 84872053875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.413856     Document Type: Article
Times cited : (19)

References (44)
  • 1
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan, B. L. (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594
    • (1996) Genes Dev. , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 3
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • Ying, Q. L., Nichols, J., Chambers, I., and Smith, A. (2003) BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281-292
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 4
    • 34848891273 scopus 로고    scopus 로고
    • Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary
    • Pan, L., Chen, S., Weng, C., Call, G., Zhu, D., Tang, H., Zhang, N., and Xie, T. (2007) Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary. Cell stem cell 1, 458-469
    • (2007) Cell Stem Cell , vol.1 , pp. 458-469
    • Pan, L.1    Chen, S.2    Weng, C.3    Call, G.4    Zhu, D.5    Tang, H.6    Zhang, N.7    Xie, T.8
  • 5
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-β superfamily
    • Attisano, L., and Wrana, J. L. (2002) Signal transduction by the TGF-β superfamily. Science 296, 1646-1647
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 6
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y., and Massagué, J. (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 7
    • 0028556511 scopus 로고
    • Transforming growth factor-α enhances alveolar epithelial cell repair in a new in vitro model
    • Kheradmand, F., Folkesson, H. G., Shum, L., Derynk, R., Pytela, R., and Matthay, M. A. (1994) Transforming growth factor-α enhances alveolar epithelial cell repair in a new in vitro model. Am. J. Physiol. 267, L728-L738
    • (1994) Am. J. Physiol. , vol.267
    • Kheradmand, F.1    Folkesson, H.G.2    Shum, L.3    Derynk, R.4    Pytela, R.5    Matthay, M.A.6
  • 8
    • 21344455768 scopus 로고    scopus 로고
    • BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
    • Miyazono, K., Maeda, S., and Imamura, T. (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 16, 251-263
    • (2005) Cytokine Growth Factor Rev. , vol.16 , pp. 251-263
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 9
    • 0023233755 scopus 로고
    • A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family
    • Padgett, R. W., St Johnston, R. D., and Gelbart, W. M. (1987) A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family. Nature 325, 81-84
    • (1987) Nature , vol.325 , pp. 81-84
    • Padgett, R.W.1    St Johnston, R.D.2    Gelbart, W.M.3
  • 10
    • 0025990941 scopus 로고
    • Drosophila 60A gene, another transforming growth factor β family member, is closely related to human bone morphogenetic proteins
    • Wharton, K. A., Thomsen, G. H., and Gelbart, W. M. (1991) Drosophila 60A gene, another transforming growth factor β family member, is closely related to human bone morphogenetic proteins. Proc. Natl. Acad. Sci. U. S. A. 88, 9214-9218
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 9214-9218
    • Wharton, K.A.1    Thomsen, G.H.2    Gelbart, W.M.3
  • 11
    • 0030018783 scopus 로고    scopus 로고
    • Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
    • Burke, R., and Basler, K. (1996) Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269
    • (1996) Development , vol.122 , pp. 2261-2269
    • Burke, R.1    Basler, K.2
  • 12
    • 0028954113 scopus 로고
    • Analysis of the genetic hierarchy guiding wing vein development in Drosophila
    • Sturtevant, M. A., and Bier, E. (1995) Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121, 785-801
    • (1995) Development , vol.121 , pp. 785-801
    • Sturtevant, M.A.1    Bier, E.2
  • 13
    • 38449114682 scopus 로고    scopus 로고
    • Wing vein patterning in Drosophila and the analysis of intercellular signaling
    • Blair, S. S. (2007) Wing vein patterning in Drosophila and the analysis of intercellular signaling. Annu. Rev. Cell Dev. Biol. 23, 293-319
    • (2007) Annu. Rev. Cell Dev. Biol. , vol.23 , pp. 293-319
    • Blair, S.S.1
  • 14
    • 0028218186 scopus 로고
    • The Drosophila saxophone gene: A serine-threonine kinase receptor of the TGF-β superfamily
    • Xie, T., Finelli, A. L., and Padgett, R. W. (1994) The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-β superfamily. Science 263, 1756-1759
    • (1994) Science , vol.263 , pp. 1756-1759
    • Xie, T.1    Finelli, A.L.2    Padgett, R.W.3
  • 16
    • 0028893294 scopus 로고
    • Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila
    • Raftery, L. A., Twombly, V., Wharton, K., and Gelbart, W. M. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139, 241-254
    • (1995) Genetics , vol.139 , pp. 241-254
    • Raftery, L.A.1    Twombly, V.2    Wharton, K.3    Gelbart, W.M.4
  • 17
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    • Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H., and Gelbart, W. M. (1995) Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 18
    • 33751320113 scopus 로고    scopus 로고
    • Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction
    • Satow, R., Kurisaki, A., Chan, T. C., Hamazaki, T. S., and Asashima, M. (2006) Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. Dev. Cell 11, 763-774
    • (2006) Dev. Cell , vol.11 , pp. 763-774
    • Satow, R.1    Kurisaki, A.2    Chan, T.C.3    Hamazaki, T.S.4    Asashima, M.5
  • 19
    • 33846002754 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway
    • Duan, X., Liang, Y. Y., Feng, X. H., and Lin, X. (2006) Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway. J. Biol. Chem. 281, 36526-36532
    • (2006) J. Biol. Chem. , vol.281 , pp. 36526-36532
    • Duan, X.1    Liang, Y.Y.2    Feng, X.H.3    Lin, X.4
  • 20
    • 33747044916 scopus 로고    scopus 로고
    • Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling
    • Knockaert, M., Sapkota, G., Alarcón, C., Massagué, J., and Brivanlou, A. H. (2006) Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc. Natl. Acad. Sci. U. S. A. 103, 11940-11945
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 11940-11945
    • Knockaert, M.1    Sapkota, G.2    Alarcón, C.3    Massagué, J.4    Brivanlou, A.H.5
  • 21
    • 33644996932 scopus 로고    scopus 로고
    • Identification of phosphatases for Smad in the BMP/DPP pathway
    • Chen, H. B., Shen, J., Ip, Y. T., and Xu, L. (2006) Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev. 20, 648-653
    • (2006) Genes Dev. , vol.20 , pp. 648-653
    • Chen, H.B.1    Shen, J.2    Ip, Y.T.3    Xu, L.4
  • 22
    • 77950874802 scopus 로고    scopus 로고
    • MTMR4 attenuates transforming growth factor β (TGFβ) signaling by dephosphorylating R-Smads in endosomes
    • Yu, J., Pan, L., Qin, X., Chen, H., Xu, Y., Chen, Y., and Tang, H. (2010) MTMR4 attenuates transforming growth factor β (TGFβ) signaling by dephosphorylating R-Smads in endosomes. J. Biol. Chem. 285, 8454-8462
    • (2010) J. Biol. Chem. , vol.285 , pp. 8454-8462
    • Yu, J.1    Pan, L.2    Qin, X.3    Chen, H.4    Xu, Y.5    Chen, Y.6    Tang, H.7
  • 23
    • 0141891208 scopus 로고    scopus 로고
    • Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases
    • Laporte, J., Bedez, F., Bolino, A., and Mandel, J. L. (2003) Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases. Hum. Mol. Genet. 12 Spec No 2, R285-R292
    • (2003) Hum. Mol. Genet. , vol.12 , Issue.SPEC NO 2
    • Laporte, J.1    Bedez, F.2    Bolino, A.3    Mandel, J.L.4
  • 26
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    • Korchynskyi, O., and ten Dijke, P. (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277, 4883-4891
    • (2002) J. Biol. Chem. , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    Ten Dijke, P.2
  • 27
    • 0037698484 scopus 로고    scopus 로고
    • DSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development
    • Liang, Y. Y., Lin, X., Liang, M., Brunicardi, F. C., ten Dijke, P., Chen, Z., Choi, K. W., and Feng, X. H. (2003) dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development. J. Biol. Chem. 278, 26307-26310
    • (2003) J. Biol. Chem. , vol.278 , pp. 26307-26310
    • Liang, Y.Y.1    Lin, X.2    Liang, M.3    Brunicardi, F.C.4    Ten Dijke, P.5    Chen, Z.6    Choi, K.W.7    Feng, X.H.8
  • 28
    • 15444373128 scopus 로고    scopus 로고
    • Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells
    • Weng, C., Li, Y., Xu, D., Shi, Y., and Tang, H. (2005) Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J. Biol. Chem. 280, 10491-10500
    • (2005) J. Biol. Chem. , vol.280 , pp. 10491-10500
    • Weng, C.1    Li, Y.2    Xu, D.3    Shi, Y.4    Tang, H.5
  • 29
    • 3543053797 scopus 로고    scopus 로고
    • Spatio-temporal activation of Smad1 and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins
    • Monteiro, R. M., de Sousa Lopes, S. M., Korchynskyi, O., ten Dijke, P., and Mummery, C. L. (2004) Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins. J. Cell Sci. 117, 4653-4663
    • (2004) J. Cell Sci. , vol.117 , pp. 4653-4663
    • Monteiro, R.M.1    De Sousa Lopes, S.M.2    Korchynskyi, O.3    Ten Dijke, P.4    Mummery, C.L.5
  • 30
    • 0037167519 scopus 로고    scopus 로고
    • Id: A target of BMP signaling
    • Miyazono, K., and Miyazawa, K. (2002) Id: a target of BMP signaling. Sci STKE 2002, pe40
    • (2002) Sci STKE , vol.2002
    • Miyazono, K.1    Miyazawa, K.2
  • 31
    • 20144379460 scopus 로고    scopus 로고
    • Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1)
    • Pardali, K., Kowanetz, M., Heldin, C. H., and Moustakas, A. (2005) Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1). J. Cell. Physiol. 204, 260-272
    • (2005) J. Cell. Physiol. , vol.204 , pp. 260-272
    • Pardali, K.1    Kowanetz, M.2    Heldin, C.H.3    Moustakas, A.4
  • 32
    • 0028981084 scopus 로고
    • Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing
    • Simmonds, A. J., Brook, W. J., Cohen, S. M., and Bell, J. B. (1995) Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing. Nature 376, 424-427
    • (1995) Nature , vol.376 , pp. 424-427
    • Simmonds, A.J.1    Brook, W.J.2    Cohen, S.M.3    Bell, J.B.4
  • 33
    • 33746820982 scopus 로고    scopus 로고
    • Systematic analysis of myotubularins: Heteromeric interactions, subcellular localisation and endosome related functions
    • Lorenzo, O., Urbé, S., and Clague, M. J. (2006) Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J. Cell Sci. 119, 2953-2959
    • (2006) J. Cell Sci. , vol.119 , pp. 2953-2959
    • Lorenzo, O.1    Urbé, S.2    Clague, M.J.3
  • 34
    • 0031825725 scopus 로고    scopus 로고
    • TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing
    • Khalsa, O., Yoon, J. W., Torres-Schumann, S., and Wharton, K. A. (1998) TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing. Development 125, 2723-2734
    • (1998) Development , vol.125 , pp. 2723-2734
    • Khalsa, O.1    Yoon, J.W.2    Torres-Schumann, S.3    Wharton, K.A.4
  • 35
    • 0029967209 scopus 로고    scopus 로고
    • Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
    • Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H., and Cohen, S. M. (1996) Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393
    • (1996) Nature , vol.381 , pp. 387-393
    • Lecuit, T.1    Brook, W.J.2    Ng, M.3    Calleja, M.4    Sun, H.5    Cohen, S.M.6
  • 36
    • 0242620396 scopus 로고    scopus 로고
    • Schnurri mediates Dpp-dependent repression of brinker transcription
    • Marty, T., Müller, B., Basler, K., and Affolter, M. (2000) Schnurri mediates Dpp-dependent repression of brinker transcription. Nat. Cell Biol. 2, 745-749
    • (2000) Nat. Cell Biol. , vol.2 , pp. 745-749
    • Marty, T.1    Müller, B.2    Basler, K.3    Affolter, M.4
  • 37
    • 34248231196 scopus 로고    scopus 로고
    • Endofin acts as a Smad anchor for receptor activation in BMP signaling
    • Shi, W., Chang, C., Nie, S., Xie, S., Wan, M., and Cao, X. (2007) Endofin acts as a Smad anchor for receptor activation in BMP signaling. J. Cell Sci. 120, 1216-1224
    • (2007) J. Cell Sci. , vol.120 , pp. 1216-1224
    • Shi, W.1    Chang, C.2    Nie, S.3    Xie, S.4    Wan, M.5    Cao, X.6
  • 38
    • 33745901307 scopus 로고    scopus 로고
    • Dpp and Gbb exhibit different effective ranges in the establishment of the BMP activity gradient critical for Drosophila wing patterning
    • Bangi, E., and Wharton, K. (2006) Dpp and Gbb exhibit different effective ranges in the establishment of the BMP activity gradient critical for Drosophila wing patterning. Dev. Biol. 295, 178-193
    • (2006) Dev. Biol. , vol.295 , pp. 178-193
    • Bangi, E.1    Wharton, K.2
  • 39
    • 0036894034 scopus 로고    scopus 로고
    • Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment
    • Green, J. (2002) Morphogen gradients, positional information, and Xenopus: interplay of theory and experiment. Dev. Dyn. 225, 392-408
    • (2002) Dev. Dyn. , vol.225 , pp. 392-408
    • Green, J.1
  • 40
    • 80054039657 scopus 로고    scopus 로고
    • Phosphorylation of Mad controls competition between wingless and BMP signaling
    • Eivers, E., Demagny, H., Choi, R. H., and De Robertis, E. M. (2011) Phosphorylation of Mad controls competition between wingless and BMP signaling. Sci. Signal 4, ra68
    • (2011) Sci. Signal , vol.4
    • Eivers, E.1    Demagny, H.2    Choi, R.H.3    De Robertis, E.M.4
  • 44
    • 0028068362 scopus 로고
    • Specificity of bone morphogenetic protein-related factors: Cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A
    • Staehling-Hampton, K., Jackson, P. D., Clark, M. J., Brand, A. H., and Hoffmann, F. M. (1994) Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A. Cell Growth Differ. 5, 585-593
    • (1994) Cell Growth Differ. , vol.5 , pp. 585-593
    • Staehling-Hampton, K.1    Jackson, P.D.2    Clark, M.J.3    Brand, A.H.4    Hoffmann, F.M.5


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