Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction

Circulation: Arrhythmia and Electrophysiology

Volumn 5, Issue 5, 2012, Pages 1017-1026

  Xi, Yutao ^a,b   Ai, Tomohiko ^c   De Lange, Enno ^d   Li, Zhaohui ^e   Wu, Geru ^a   Brunelli, Luca ^f   Kyle, W Buck ^j   Turker, Isik ^c   Cheng, Jie ^a   Ackerman, Michael J ^g   Kimura, Akinori ^h   Weiss, James N ^d   Qu, Zhilin ^d   Kim, Jeffrey J ^e   Faulkner, Georgine ⁱ   Vatta, Matteo ^e  

^a ST LUKE S EPISCOPAL HOSPITAL   (United States)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g MAYO CLINIC   (United States)

^h TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

ⁱ UNIVERSITY OF PADOVA   (Italy)

^j NONE

more..

Author keywords

Cardiac conduction disturbance; Left ventricular noncompaction; Sodium channel; Z band alternatively spliced PDZ motif gene

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; ACTIN; CYTOCHALASIN D; DELAYED RECTIFIER POTASSIUM CHANNEL; MESSENGER RNA; PDZ PROTEIN; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG; Z BAND ALTERNATIVELY SPLICED PDZ MOTIF PROTEIN; AZEPINE DERIVATIVE; LDB3 PROTEIN, HUMAN; LIM PROTEIN; MUSCLE PROTEIN; NAPHTHALENE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SODIUM CHANNEL NAV1.5; TCAP PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOSKELETON; DISEASE ASSOCIATION; ELECTRIC POTENTIAL; GENE LOCATION; GENE MUTATION; HEART CONDUCTION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE CONDUCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LOSS OF FUNCTION MUTATION; MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PATCH CLAMP; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SHIFT TO THE RIGHT; VENTRICULAR NONCOMPACTION; WILD TYPE; ANIMAL; CELL LINE; CYTOLOGY; GENETICS; KIDNEY; METABOLISM; PATHOPHYSIOLOGY; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AZEPINES; BLOTTING, WESTERN; CELL LINE; COMPUTER SIMULATION; CYTOCHALASIN D; HEART CONDUCTION SYSTEM; HUMANS; IMMUNOHISTOCHEMISTRY; ISOLATED NONCOMPACTION OF THE VENTRICULAR MYOCARDIUM; KIDNEY; LIM DOMAIN PROTEINS; MUSCLE PROTEINS; MYOCYTES, CARDIAC; NAPHTHALENES; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; RATS;

EID: 84872047539     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.111.969220     Document Type: Article

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