Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids

British Journal of Nutrition

Volumn 109, Issue 1, 2013, Pages 89-98

  Koppelmann, Tal ^a,b   Pollak, Yulia ^a   Mogilner, Jorge ^b   Bejar, Jacob ^b   Coran, Arnold G ^c   Sukhotnik, Igor ^a,b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Intestine; Methotrexate; Mucositis; n 3 PUFA; Rats

Indexed keywords

BETA CATENIN; DNA; MESSENGER RNA; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; OMEGA 3 FATTY ACID; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAX GENE; BCL2 GENE; CELL PROLIFERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG EFFICACY; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; ILEUM MUCOSA; INTESTINE INJURY; INTESTINE VILLUS; MALE; MICROSCOPY; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WEIGHT CHANGE; WESTERN BLOTTING;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; DIETARY SUPPLEMENTS; ENTEROCYTES; FATTY ACIDS, OMEGA-3; GENE EXPRESSION REGULATION; ILEUM; INTESTINAL MUCOSA; JEJUNUM; MALE; METHOTREXATE; MUCOSITIS; ORGAN SIZE; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

ANIMALIA; RATTUS;

EID: 84872046776     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512000542     Document Type: Article

References (29)

1. Simopoulos AP (1999) Essential fatty acids in health and chronic disease. Am J Clin Nutr 70, Suppl., 560S-569S.
2. Weber PC, Fischer S, von Schacky C, et al. (1986) Dietary omega-3 polyunsaturated fatty acids and eicosanoid formation in man. In Health Effects of Polyunsaturated Fatty Acids in Sea Foods, pp. 49-60 [AP Simopoulos, RR Kifer and RE Martin, editors]. Orlando, FL: Academic Press.
3. Ekema G, Falchetti D, Boroni G, et al. (2008) Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids). J Pediatr Surg 43, 1191-1195.
4. Eisner F, Jacob P, Frick JS, et al. (2011) Immunonutrition with long-chain fatty acids prevents activation of macrophages in the gut wall. J Gastrointest Surg 15, 853-859.
5. Meydani SN, Lichtenstein AH, Cornwall S, et al. (1993) Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment. J Clin Invest 92, 105-113.
6. Loeschke K, Ueberschaer B & Pietsch A (1996) n-3 Fatty acids only delay early relapse of ulcerative colitis in remission. Dig Dis Sci 41, 2087-2094.
7. Aslan A & Triadafilopoulos G (1992) Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol 87, 432-437.
8. Kremer JM, Lawrence DA, Petrillo GF, et al. (1995) Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs: clinical and immune correlates. Arthritis Rheum 38, 1107-1114.
9. Geusens P, Wouters C, Nijs J, et al. (1994) Long term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis: a 12 month, double blind, controlled study. Arthritis Rheum 37, 824-829.
10. Schmöcker C, Weylandt KH, Kahlke L, et al. (2007) Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology 45, 864-869.
11. Sonis ST (1993) Complications of cancer and their treatment: oral complications. In Cancer Medicine, 3rd ed., pp. 2381-2388 [JF Holland, E Frei and RC Bast, editors]. Philadelphia: Lea and Febiger.
12. Naidu MU, Ramana GV, Rani PU, et al. (2004) Chemotherapyinduced and/or radiation therapy-induced oral mucositis? Complicating the treatment of cancer. Neoplasia 6, 423-431.
13. Sonis ST, Elting LS, Keefe DMK, et al. (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100, 1995-2025.
14. Kesik V, Uysal B, Kurt B, et al. (2009) Ozone ameliorates methotrexate-induced intestinal injury in rats. Cancer Biol Ther 8, 1623-1628.
15. Dyerberg J, Bang HO & Hjorne N (1975) Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr 28, 958-967.
16. Simopoulos AP, Kifer RR, Wykes AA, et al. (1991) Omega 3 fatty acids: research advances and support in the field since June 1985 (worldwide). World Rev Nutr Diet 66, 51-71.
17. LevyAE&AlexanderJW(1995)Nutritionalimmunomodulation enhances cardiac allograft survival in rats treated with donorspecific transfusion and CsA. Transplantation 60, 812-815.
18. Calder PC, Yaqoob P, Harvey DJ, et al. (1994) The incorporation of fatty acids by lymphocytes and the effect on fatty acid composition and membrane fluidity. Biochem J 300, 509-518.
19. Yaqoob P, Newsholme EA & Calder PC (1995) Influence of cell culture conditions on diet-induced changes in lymphocyte fatty acid composition. Biochim Biophys Acta 1255, 333-340.
20. Lewis RA, Lee TH & Austen KF (1986) Effects of omega-3 fatty acids on the generation of products of the 5-lipoxygenase pathway. In Health Effects of Polyunsaturated Fatty Acids in Sea Foods, pp. 227-238 [AP Simopoulos, RR Kifer and RE Martin, editors]. Orlando, FL: Academic Press.
21. Shoda R, Matsueda K, Yamato S, et al. (1995) Therapeutic efficacy of n-3 polyunsaturated fatty acid in experimental Crohn's disease. J Gastroenterol 30, Suppl. 80, 98-101.
22. Hillier K, Jewell R, Dorrell L, et al. (1991) Incorporation of fatty acids from fish oil and olive oil into colonic mucosal lipids and effects upon eicosanoid synthesis in inflammatory bowel disease. Gut 32, 1151-1155.
23. Haegebarth A & Clevers H (2009) Wnt signaling, Lgr5, and stem cells in the intestine. Am J Pathol 174, 15-21.
24. Sukhotnik I, Mogilner J, Karry R, et al. (2009) Effect of oral glutamine on enterocyte turnover during methotrexateinduced mucositis in a rat. Digestion 79, 5-13.
25. Sukhotnik I, Mogilner JG, Shteinberg D, et al. (2009) Leptin accelerates enterocyte turnover during methotrexateinduced intestinal mucositis in a rat. Cancer Biol Ther 8, 1-7.
26. Calder PC (2009) Fatty acids and immune function: relevance to inflammatory bowel diseases. Int Rev Immunol 28, 506-534.
27. Calderaro V, Parrillo C, Balestrieri ML, et al. (1994) Docosahexaenoic acid and signaling pathways in rabbit colon. Mol Pharmacol 45, 737-746.
28. Pearson G, Robinson F, Beers Gibson T, et al. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22, 153-183.
29. Logan RM, Stringer AM, Bowen JM, et al. (2008) Serum levels of NF-kB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol Ther 7, 1139-1145.