γ-Amino butyric acid analogs as novel potent GABA-AT inhibitors: Molecular docking, synthesis, and biological evaluation

Medicinal Chemistry Research

Volumn 22, Issue 1, 2013, Pages 134-146

  Bansal, S K ^a   Sinha, B N ^b   Khosa, R L ^a  

^a BHARAT INSTITUTE OF TECHNOLOGY   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

AutoDock 4.0.1; Docking simulation; GABA; GABA AT inhibitor; IC50; Lamarckian genetic algorithm

Indexed keywords

3 [(1,4,5,8 TETRACHLORO 10 OXO 9,10 DIHYDROANTHRACENE 9 YLIDENE)AMINO]BENZOIC ACID; 3 [(10 OXO 9,10 DIHYDROANTHRACENE 9 YLIDENE)AMINO]BENZOIC ACID; 3 [(10 OXO 9,10 DIHYDROPHENANTHRENE 9 YLIDENE)AMINO]BENZOIC ACID; 3 [(2 ETHYL 10 OXO 9,10 DIHYDROANTHRACENE 9 YLIDENE)AMINO]BENZOIC ACID; 3 [(2,3,5,6 TETRAMETHYL 4 OXOCYCLOHEXA 2,5 DIEN 1 YLIDENE)AMINO]BENZOIC ACID; 3 AMINO N' (2,3,5,6 TETRACHLORO 4 OXOCYCLOHEXA 2,5 DIEN 1 YLIDENE)BENZOHYDRAZIDE; 3 AMINO N' [1 (3 CHLOROPHENYL)ETHYLIDENE]BENZOHYDRAZIDE; 3 AMINO N' [1, 2 DIHYDROXY 10 OXO 9,10 DIHYDROANTHRACENE 9 YLIDENE]BENZOHYDRAZIDE; 3 AMINO N' [2 CHLORO 10 OXO 9,10 DIHYDROANTHRACENE 9 YLIDENE]BENZOHYDRAZIDE; 3 AMINO N' [4 CHLOROPHENYL(PHENYL)METHYLIDENE]BENZOHYDRAZIDE; 4 [(1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)AMINO]BUTANOIC ACID; 4 [(1,5 DIPHENYLPENTA 1,4 DIEN 3 YLIDENE)AMINO]BUTANOIC ACID; 4 [(10 OXO 9,10 DIHYDROPHENANTHRENE 9 YLIDENE)AMINO]BUTANOIC ACID; 4 [(2 METHYL 4 OXOCYCLOHEXA 2,5 DIEN 1 YLIDENE)AMINO]BUTANOIC ACID; 4 [[1 (NAPHTHALEN 2 YL)ETHYLIDENE]AMINO]BUTANOIC ACID; 4 AMINO N [1 (2 BROMOPHENYL)ETHYLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' (10 OXO 9, 10 DIHYDROANTHRACENE 9 YLIDENE)BUTANEHYDRAZIDE; 4 AMINO N' [1 (2 BROMOPHENYL)ETHYLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [1 (3 CHLOROPHENYL)ETHYLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [1, 2, 3, 4 TETRAHYDRONAPHTHALENE 2 YLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [1,2,3,4 TETRAHYDRONAPHTHALEN 1 YLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [2 IODOPHENYLMETHYLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [2 METHYL 10 OXO 9,10 DIHYDROANTHRACENE 9 YLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [2 OXO 1, 2 DIPHENYLETHYLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [3 IODOPHENYLMETHYLIDENE]BUTANEHYDRAZIDE; 4 AMINO N' [4 BROMOPHENYL(PHENYL)METHYLIDENE]BUTANEHYDRAZIDE; 4 AMINOBUTYRIC ACID; SCHIFF BASE; UNCLASSIFIED DRUG; VIGABATRIN;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 84872044582     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0023-0     Document Type: Article

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