Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR-guided high-intensity focused ultrasound mediated mild hyperthermia

Medical Physics

Volumn 40, Issue 1, 2013, Pages

  Partanen, Ari ^a,b,c   Tillander, Matti ^c   Yarmolenko, Pavel S ^a,d   Wood, Bradford J ^a   Dreher, Matthew R ^a   Köhler, Max O ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c PHILIPS HEALTHCARE   (United States)

^d Duke University   (United States)

Author keywords

mild hyperthermia; MR HIFU; multifoci; thermotherapy

Indexed keywords

ASPECT RATIO; CHEMOTHERAPY; CONCURRENCY CONTROL; ENERGY EFFICIENCY; HEATING; HYDROPHONES; MAGNETIC RESONANCE IMAGING; MUSCLE; PHANTOMS; PRESSURE CONTROL; SONICATION; STATISTICS; TUMORS; ULTRASONICS;

HIGH INTENSITY FOCUSED ULTRASOUND; HYPERTHERMIA APPLICATIONS; HYPERTHERMIA TREATMENTS; MILD HYPERTHERMIA; MR-HIFU; MULTIFOCI; TEMPERATURE ACCURACIES; THERMOTHERAPIES;

HYPERTHERMIA THERAPY;

ACCURACY; ALGORITHM; ANALOG DIGITAL CONVERTER; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CELL SIZE; COMPUTER MODEL; CONTROLLED STUDY; DENSITY; ENERGY; EXPERIMENTAL RABBIT; FEEDBACK SYSTEM; HEATING; HIGH INTENSITY FOCUSED ULTRASOUND; HYPERTHERMIA; MAGNETIC RESONANCE IMAGING GUIDED HIGH INTENSITY FOCUSED ULTRASOUND; NEEDLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PERFUSION; PHANTOM; PRESSURE; PRIORITY JOURNAL; SIMULATION; SKELETAL MUSCLE; TEMPERATURE; THERMAL CONDUCTIVITY; TREATMENT PLANNING; TUMOR VOLUME; VELOCITY; ACOUSTICS; ANIMAL; COMPUTER ASSISTED SURGERY; HEAT; HYPERTHERMIC THERAPY; IMAGE QUALITY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; RABBIT; RISK; ULTRASOUND;

ORYCTOLAGUS CUNICULUS;

ACOUSTICS; ANIMALS; HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION; HOT TEMPERATURE; HYPERTHERMIA, INDUCED; MAGNETIC RESONANCE IMAGING; PHANTOMS, IMAGING; PRESSURE; RABBITS; RISK; SONICATION; SURGERY, COMPUTER-ASSISTED;

EID: 84872044348     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.4769116     Document Type: Article

References (64)

1. B. J. Wood, J. R. Ramkaransingh, T. Fojo, M. M. Walther, and S. K. Libutti, " Percutaneous tumor ablation with radiofrequency.," Cancer 94, 443-451 (2002). 10.1002/cncr.10234 (Pubitemid 34081375)
2. B. L. Viglianti, P. Stauffer, E. Repasky, E. Jones, Z. Vujaskovic, and M. W. Dewhirst, " Hyperthermia.," in Holland-Frei Cancer Medicine, edited by, W. K. Hong, (People's Medical Publishing House, Shelton, CT, 2010), pp. 528-540.
3. R. D. Issels, L. H. Lindner, J. Verweij, P. Wust, P. Reichardt, B. C. Schem, S. Abdel-Rahman, S. Daugaard, C. Salat, C. M. Wendtner, Z. Vujaskovic, R. Wessalowski, K. W. Jauch, H. R. Durr, F. Ploner, A. Baur-Melnyk, U. Mansmann, W. Hiddemann, J. Y. Blay, and P. Hohenberger, " Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: A randomised phase 3 multicentre study.," Lancet Oncol. 11, 561-570 (2010). 10.1016/S1470-2045(10)70071-1
4. J. van der Zee, " Heating the patient: A promising approach," Ann. Oncol. 13, 1173-1184 (2002). 10.1093/annonc/mdf280 (Pubitemid 34960124)
5. M. H. Falk and R. D. Issels, " Hyperthermia in oncology.," Int. J. Hyperthermia 17, 1-18 (2001). 10.1080/02656730150201552 (Pubitemid 32058478)
6. P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, and P. M. Schlag, " Hyperthermia in combined treatment of cancer.," Lancet Oncol. 3, 487-497 (2002). 10.1016/S1470-2045(02)00818-5 (Pubitemid 34863670)
7. P. M. Krawczyk, B. Eppink, J. Essers, J. Stap, H. Rodermond, H. Odijk, A. Zelensky, C. van Bree, L. J. Stalpers, M. R. Buist, T. Soullie, J. Rens, H. J. Verhagen, M. J. O'Connor, N. A. Franken, T. L. Ten Hagen, R. Kanaar, and J. A. Aten, " Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.," Proc. Natl. Acad. Sci. U.S.A. 108, 9851-9856 (2011). 10.1073/pnas.1101053108
8. J. J. Skitzki, E. A. Repasky, and S. S. Evans, " Hyperthermia as an immunotherapy strategy for cancer.," Curr. Opin. Invest. Drugs 10, 550-558 (2009).
9. M. D. Hurwitz, " Today's thermal therapy: Not your father's hyperthermia: Challenges and opportunities in application of hyperthermia for the 21st century cancer patient.," Am. J. Clin. Oncol. 33, 96-100 (2010). 10.1097/COC.0b013e3181817a75
10. L. Wu, R. J. McGough, O. A. Arabe, and T. V. Samulski, " An RF phased array applicator designed for hyperthermia breast cancer treatments.," Phys. Med. Biol. 51, 1-20 (2006). 10.1088/0031-9155/51/1/001 (Pubitemid 41803465)
11. M. Weihrauch, P. Wust, M. Weiser, J. Nadobny, S. Eisenhardt, V. Budach, and J. Gellermann, " Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a hybrid MR-HT system.," Med. Phys. 34, 4717-4725 (2007). 10.1118/1.2804617 (Pubitemid 350197710)
12. J. E. Johnson, D. G. Neuman, P. F. Maccarini, T. Juang, P. R. Stauffer, and P. Turner, " Evaluation of a dual-arm Archimedean spiral array for microwave hyperthermia.," Int. J. Hyperthermia 22, 475-490 (2006). 10.1080/02656730600905595 (Pubitemid 44446562)
13. T. Juang, P. R. Stauffer, D. G. Neuman, and J. L. Schlorff, " Multilayer conformal applicator for microwave heating and brachytherapy treatment of superficial tissue disease.," Int. J. Hyperthermia 22, 527-544 (2006). 10.1080/02656730600931815 (Pubitemid 44669660)
14. D. R. Boreham, H. C. Gasmann, and R. E. Mitchel, " Water bath hyperthermia is a simple therapy for psoriasis and also stimulates skin tanning in response to sunlight.," Int. J. Hyperthermia 11, 745-754 (1995). 10.3109/02656739509052332
15. R. J. McNichols, M. Kangasniemi, A. Gowda, J. A. Bankson, R. E. Price, and J. D. Hazle, " Technical developments for cerebral thermal treatment: water-cooled diffusing laser fibre tips and temperature-sensitive MRI using intersecting image planes.," Int. J. Hyperthermia 20, 45-56 (2004). 10.1080/02656730310001611035 (Pubitemid 38180573)
16. M. Kangasniemi, R. J. McNichols, J. A. Bankson, A. Gowda, R. E. Price, and J. D. Hazle, " Thermal therapy of canine cerebral tumors using a 980 nm diode laser with MR temperature-sensitive imaging feedback.," Lasers Surg. Med. 35, 41-50 (2004). 10.1002/lsm.20069 (Pubitemid 39063255)
17. T. O. Tasci, I. Vargel, A. Arat, E. Guzel, P. Korkusuz, and E. Atalar, " Focused RF hyperthermia using magnetic fluids.," Med. Phys. 36, 1906-1912 (2009). 10.1118/1.3106343
18. A. Jordan, P. Wust, H. Fahling, W. John, A. Hinz, and R. Felix, " Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. 1993.," Int. J. Hyperthermia 25, 499-511 (2009). 10.3109/02656730903287790
19. Y. Ishihara, A. Calderon, H. Watanabe, K. Okamoto, Y. Suzuki, and K. Kuroda, " A precise and fast temperature mapping using water proton chemical shift.," Magn. Reson. Med. 34, 814-823 (1995). 10.1002/mrm.1910340606
20. B. D. de Senneville, B. Quesson, and C. T. Moonen, " Magnetic resonance temperature imaging.," Int. J. Hyperthermia 21, 515-531 (2005). 10.1080/02656730500133785 (Pubitemid 41726061)
21. K. Kuroda, A. H. Chung, K. Hynynen, and F. A. Jolesz, " Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery.," J. Magn. Reson. Imaging 8, 175-181 (1998). 10.1002/jmri.1880080130 (Pubitemid 28099575)
22. W. J. Fry, V. J. Wulff, D. Tucker, and F. J. Fry, " Physical factors involved in ultrasonically induced changes in living systems: I. Identification of non-temperature effects.," J. Acoust. Soc. Am. 22, 867-876 (1950). 10.1121/1.1906707
23. W. D. O'Brien Jr., " Ultrasound-biophysics mechanisms.," Prog. Biophys. Mol. Biol. 93, 212-255 (2007). 10.1016/j.pbiomolbio.2006.07.010 (Pubitemid 44809389)
24. M. Bailey, V. Khokhlova, O. Sapozhnikov, S. Kargl, and L. Crum, " Physical mechanisms of the therapeutic effect of ultrasound (a review).," Acoust. Phys. 49, 369-388 (2003). 10.1134/1.1591291 (Pubitemid 37056472)
25. D. Melodelima, J. Y. Chapelon, Y. Theillere, and D. Cathignol, " Combination of thermal and cavitation effects to generate deep lesions with an endocavitary applicator using a plane transducer: ex vivo studies.," Ultrasound Med. Biol. 30, 103-111 (2004). 10.1016/j.ultrasmedbio.2003.09.005 (Pubitemid 38201446)
26. S. D. Sokka, R. King, and K. Hynynen, " MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh.," Phys. Med. Biol. 48, 223-241 (2003). 10.1088/0031-9155/48/2/306 (Pubitemid 36204158)
27. A. Yudina, M. de Smet, M. Lepetit-Coiffe, S. Langereis, L. Van Ruijssevelt, P. Smirnov, V. Bouchaud, P. Voisin, H. Grull, and C. T. Moonen, " Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes.," J. Controlled Release 155, 442-448 (2011). 10.1016/j.jconrel.2011.06.006
28. V. Frenkel, J. Oberoi, M. J. Stone, M. Park, C. Deng, B. J. Wood, Z. Neeman, M. Horne III, and K. C. Li, " Pulsed high-intensity focused ultrasound enhances thrombolysis in an in vitro model.," Radiology 239, 86-93 (2006). 10.1148/radiol.2391042181
29. C. K. Holland and R. E. Apfel, " Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment.," J. Acoust. Soc. Am. 88, 2059-2069 (1990). 10.1121/1.400102
30. M. S. Canney, M. R. Bailey, L. A. Crum, V. A. Khokhlova, and O. A. Sapozhnikov, " Acoustic characterization of high intensity focused ultrasound fields: A combined measurement and modeling approach.," J. Acoust. Soc. Am. 124, 2406-2420 (2008). 10.1121/1.2967836
31. D. Dalecki, E. L. Carstensen, K. J. Parker, and D. R. Bacon, " Absorption of finite amplitude focused ultrasound.," J. Acoust. Soc. Am. 89, 2435-2447 (1991). 10.1121/1.400976
32. K. Hynynen, " Demonstration of enhanced temperature elevation due to nonlinear propagation of focussed ultrasound in dog's thigh in vivo.," Ultrasound Med. Biol. 13, 85-91 (1987). 10.1016/0301-5629(87)90078-0 (Pubitemid 17031284)
33. E. Filonenko and V. Khokhlova, " Effect of acoustic nonlinearity on heating of biological tissue by high-intensity focused ultrasound.," Acoust. Phys. 47, 468-475 (2001). 10.1134/1.1385422
34. M. S. Canney, V. A. Khokhlova, O. V. Bessonova, M. R. Bailey, and L. A. Crum, " Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound.," Ultrasound Med. Biol. 36, 250-267 (2010). 10.1016/j.ultrasmedbio.2009.09.010
35. D. R. Daum and K. Hynynen, " Thermal dose optimization via temporal switching in ultrasound surgery.," IEEE Trans. Ultrason. Ferroelectr. Freq. Control 45, 208-215 (1998). 10.1109/58.646926 (Pubitemid 128748681)
36. E. S. Ebbini and C. A. Cain, " Multiple-focus ultrasound phased-array pattern synthesis: Optimal driving-signal distributions for hyperthermia.," IEEE Trans. Ultrason. Ferroelectr. Freq. Control 36, 540-548 (1989). 10.1109/58.31798 (Pubitemid 20607080)
37. X. Fan and K. Hynynen, " Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16-element phased array.," Med. Phys. 22, 297-306 (1995). 10.1118/1.597603
38. H. L. Liu, W. L. Lin, and Y. Y. Chen, " A fast and conformal heating scheme for producing large thermal lesions using a 2D ultrasound phased array.," Int. J. Hyperthermia 23, 69-82 (2007). 10.1080/02656730601087518 (Pubitemid 46957650)
39. M. O. Köhler, C. Mougenot, B. Quesson, J. Enholm, B. Le Bail, C. Laurent, C. T. Moonen, and G. J. Ehnholm, " Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry.," Med. Phys. 36, 3521-3535 (2009). 10.1118/1.3152112
40. Y. S. Kim, B. Keserci, A. Partanen, H. Rhim, H. K. Lim, M. J. Park, and M. O. Köhler, " Volumetric MR-HIFU ablation of uterine fibroids: Role of treatment cell size in the improvement of energy efficiency.," Eur. J. Radiol. 81 (11), 3652-3659 (2012). 10.1016/j.ejrad.2011.09.005
41. C. Mougenot, M. O. Köhler, J. Enholm, B. Quesson, and C. Moonen, " Quantification of near-field heating during volumetric MR-HIFU ablation.," Med. Phys. 38, 272-282 (2011). 10.1118/1.3518083
42. A. Partanen, P. S. Yarmolenko, A. Viitala, S. Appanaboyina, D. Haemmerich, A. Ranjan, G. Jacobs, D. Woods, J. Enholm, B. J. Wood, and M. R. Dreher, " Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery.," Int. J. Hyperthermia 28, 320-336 (2012). 10.3109/02656736.2012.680173
43. J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. Moonen, and S. D. Sokka, " Improved volumetric MR-HIFU ablation by robust binary feedback control.," IEEE Trans. Biomed. Eng. 57, 103-113 (2010). 10.1109/TBME.2009.2034636
44. H. T. O'Neil, " Theory of focusing radiators.," J. Acoust. Soc. Am. 21, 516-526 (1949). 10.1121/1.1906542
45. F. A. Duck, Physical Properties of Tissue: A Comprehensive Reference Book (Academic Press Inc., San Diego, CA, 1990).
46. S. A. Goss, R. L. Johnston, and F. Dunn, " Comprehensive compilation of empirical ultrasonic properties of mammalian tissues.," J. Acoust. Soc. Am. 64, 423-457 (1978). 10.1121/1.382016 (Pubitemid 9001200)
47. J. W. Valvano, " Tissue Thermal Properties And Perfusion.," in Optical-Thermal Response of Laser-Irradiated Tissue, edited by, A. J. Welch, (Springer, Dordrecht, the Netherlands, 2011).
48. H. H. Pennes, " Analysis of tissue and arterial blood temperatures in the resting human forearm.," J. Appl. Physiol. 1, 93-122 (1948).
49. I. Dragonu, P. L. de Oliveira, C. Laurent, C. Mougenot, N. Grenier, C. T. Moonen, and B. Quesson, " Non-invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry.," NMR Biomed. 22, 843-851 (2009). 10.1002/nbm.1397
50. IEC, " IEC/TS 61949 ed1.0; Ultrasonics-Field characterization-In situ exposure estimation in finite-amplitude ultrasonic beams. " (IEC, Geneva, 2007).
51. A. Partanen, C. Mougenot, and T. Vaara, " Feasibility of agar-silica phantoms in quality assurance of MRgHIFU.," AIP Conf. Proc. 1113, 296-300 (2009). 10.1063/1.3131434
52. A. Ranjan, G. C. Jacobs, D. L. Woods, A. H. Negussie, A. Partanen, P. S. Yarmolenko, C. E. Gacchina, K. V. Sharma, V. Frenkel, B. J. Wood, and M. R. Dreher, " Image-guided drug delivery with magnetic resonance guid-ed high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model.," J. Controlled Release 158, 487-494 (2012). 10.1016/j.jconrel.2011.12.011
53. G. ter Haar, A. Shaw, S. Pye, B. Ward, F. Bottomley, R. Nolan, and A. M. Coady, " Guidance on reporting ultrasound exposure conditions for bio-effects studies.," Ultrasound Med. Biol. 37, 177-183 (2011). 10.1016/j.ultrasmedbio.2010.10.021
54. S. A. Sapareto and W. C. Dewey, " Thermal dose determination in cancer therapy.," Int. J. Radiat. Oncol. Biol. Phys. 10, 787-800 (1984). 10.1016/0360-3016(84)90379-1 (Pubitemid 14094055)
55. A. D. Maxwell, G. Owens, H. S. Gurm, K. Ives, D. D. Myers Jr., and Z. Xu, " Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model.," J. Vasc. Interv. Radiol. 22, 369-377 (2011). 10.1016/j.jvir.2010.10.007
56. C. C. Coussios, C. H. Farny, G. T. Haar, and R. A. Roy, " Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU).," Int. J. Hyperthermia 23, 105-120 (2007). 10.1080/02656730701194131 (Pubitemid 46404249)
57. P. R. Patel, A. Luk, A. Durrani, S. Dromi, J. Cuesta, M. Angstadt, M. R. Dreher, B. J. Wood, and V. Frenkel, " In vitro and in vivo evaluations of increased effective beam width for heat deposition using a split focus high intensity ultrasound (HIFU) transducer.," Int. J. Hyperthermia 24, 537-549 (2008). 10.1080/02656730802064621
58. N. M. Hijnen, E. Heijman, M. O. Köhler, M. Ylihautala, G. J. Ehnholm, A. W. Simonetti, and H. Grull, " Tumour hyperthermia and ablation in rats using a clinical MR-HIFU system equipped with a dedicated small animal set-up.," Int. J. Hyperthermia 28, 141-155 (2012). 10.3109/02656736.2011. 648137
59. D. L. Miller and C. Dou, " The potential for enhancement of mouse melanoma metastasis by diagnostic and high-amplitude ultrasound.," Ultrasound Med. Biol. 32, 1097-1101 (2006). 10.1016/j.ultrasmedbio.2006.03.013 (Pubitemid 43994300)
60. G. O. Oosterhof, E. B. Cornel, G. A. Smits, F. M. Debruyne, and J. A. Schalken, " The influence of high-energy shock waves on the development of metastases.," Ultrasound Med. Biol. 22, 339-344 (1996). 10.1016/0301-5629(95)02051-9 (Pubitemid 26138559)
61. D. L. Miller, C. Dou, and J. Song, " Lithotripter shockwave-induced enhancement of mouse melanoma lung metastasis: Dependence on cavitation nucleation.," J. Endourol. 18, 925-929 (2004). 10.1089/end.2004.18.925 (Pubitemid 39627579)
62. K. Hynynen, " The threshold for thermally significant cavitation in dog's thigh muscle in vivo.," Ultrasound Med. Biol. 17, 157-169 (1991). 10.1016/0301-5629(91)90123-E
63. M. J. Voogt, H. Trillaud, Y. S. Kim, W. P. Mali, J. Barkhausen, L. W. Bartels, R. Deckers, N. Frulio, H. Rhim, H. K. Lim, T. Eckey, H. J. Nieminen, C. Mougenot, B. Keserci, J. Soini, T. Vaara, M. O. Köhler, S. Sokka, and M. A. van den Bosch, " Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy.," Eur. Radiol. 22, 411-417 (2012). 10.1007/s00330-011-2262-8
64. S. Wang, V. Zderic, and V. Frenkel, " Extracorporeal, low-energy focused ultrasound for noninvasive and nondestructive targeted hyperthermia.," Future Oncol. 6, 1497-1511 (2010). 10.2217/fon.10.101