Dorsomedial/perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 11, 2012, Pages 7328-7335

  Samuels, Brian C ^a   Hammes, Nathan M ^a   Johnson, Philip L ^a   Shekhar, Anantha ^a,b   McKinnon, Stuart J ^c   Rand Allingham, R ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Indiana Clinical and Translational Sciences Institute   (United States)

^c DUKE UNIVERSITY EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICUCULLINE METHIODIDE; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BODY MASS; CIRCADIAN RHYTHM; DISEASE COURSE; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; HEART RATE; HISTOLOGY; INTRAOCULAR PRESSURE; MAL; MICROINJECTION; NONHUMAN; PRESSURE GRADIENT; PRIORITY JOURNAL; RAT; STIMULATION; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; GLAUCOMA; INTRACRANIAL PRESSURE; MALE; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ARTERIAL PRESSURE; BICUCULLINE; DISEASE MODELS, ANIMAL; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; GABA-A RECEPTOR ANTAGONISTS; GLAUCOMA; INTRACRANIAL PRESSURE; INTRAOCULAR PRESSURE; MALE; MICROINJECTIONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84872041100     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10632     Document Type: Article

References (82)

1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262-267.
2. Friedman DS, Wolfs RC, O'Colmain BJ, et al. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004;122:532-538.
3. Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:714-20; discussion 829-830.
4. Leske MC, Connell AM, Wu SY, et al. Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. Arch Ophthalmol. 2001;119:89-95.
5. Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of primary open angle glaucoma. JAMA. 1991;266:369-374.
6. Leske MC, Connell AMS, Schachat AP, Hyman L. The Barbados Eye Study-prevalence of open angle glaucoma. Arch Ophthalmol. 1994;112:821-829.
7. Le A, Mukesh BN, McCarty CA, Taylor HR. Risk factors associated with the incidence of open-angle glaucoma: the visual impairment project. Invest Ophthalmol Vis Sci. 2003; 44:3783-3789.
8. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B, BESs Study Group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology. 2008;115:85-93.
9. Banks JLK, Perkins ES, Tsolakis S, Wright JE. Bedford Glaucoma Survey. Br Med J. 1968;30:791-879.
10. Tielsch JM, Katz J, Singh K, et al. A population based evaluation of glaucoma screening: the Baltimore eye survey. Am J Epidemiol. 1991;134:1102-1110.
11. Sommer A, Tielsch JM, Katz J, et al. Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol. 1991;109:1090-1095.
12. Weih LM, Nanjan M, McCarty CA, Taylor HR. Prevalence and predictors of open-angle glaucoma: results from the visual impairment project. Ophthalmology. 2001;108:1966-1972.
13. Dielemans I, Vingerling JR, Wolfs RC, Hofman A, Grobbee DE, de Jong PT. The prevalence of primary open-angle glaucoma in a population-based study in The Netherlands. The Rotterdam Study. Ophthalmology. 1994;101:1851-1855.
14. Mitchell P, Smith W, Attebo K, Healey PR. Prevalence of openangle glaucoma in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996;103:1661-1669.
15. Quigley HA, West SK, Rodriguez J, Munoz B, Klein R, Snyder R. The prevalence of glaucoma in a population-based study of Hispanic subjects. Proyecto Ver. Arch Ophthalmol. 2001;119: 1819-1826.
16. Berdahl JP, Allingham RR, Johnson DH. "Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. " Ophthalmology. 2008;115:763-768.
17. Berdahl JP, Fautsch MP, Stinnett SS, Allingham RR. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci. 2008;49:5412-5418.
18. Ren R, Jonas JB, Tian G, et al. Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology. 2010;117: 259-266.
19. Ren R, Zhang X, Wang N, Li B, Tian G, Jonas JB. Cerebrospinal fluid pressure in ocular hypertension. Acta Ophthalmol. 2011; 89:e142-e148.
20. Asrani S, Zeimer R, Wilensky J, Gieser D, Vitale S, Lindenmuth K. Large diurnal fluctuations in IOP are an independent risk factor in patients with glaucoma. J Glaucoma. 2000;9:134-142.
21. Lee PP, Walt JW, Rosenblatt LC, Siegartel LR, Stern LS, Glaucoma Care Study Group. Association between IOP variation and glaucoma progression: data from a United States chart review. Am J Ophthalmol. 2007;144:901-907.
22. Hong S, Hong YJ, Seong GJ. Long term IOP fluctuation and visual field progression in glaucoma patients with low IOP after triple procedure. Arch Ophthalmol. 2007;125:1010-1013.
23. Caprioli J, Coleman AL. IOP fluctuation a risk factor for visual field progression at low IOPs in the Advanced Glaucoma Intervention Study. Ophthalmology. 2008;115:1123-1129.
24. Jung BC, Dave AS, Tan AY, et al. Circadian variations of stellate ganglion nerve activity in ambulatory dogs. Heart Rhythm. 2006;3:78-85.
25. Lee PW, Doyle A, Stewart JA, Kristoffersen CJ, Stewart WC. Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure. Eur J Ophthalmol. 2010;20: 1035-1041.
26. Stewart WC, Konstas AG, Nelson LA, Kruft B. Meta-analysis of 24-hour intraocular pressure studies evaluating the efficacy of glaucoma medicines. Ophthalmology. 2008;115:1117-1122.
27. Bloomfield S. Relative deficiency of parasympathomimetic activity in aqueous of eyes with chronic simple glaucoma. Arch Ophthal. 1947;37:608-617.
28. Niedermeier S. Glaukom und Sympathikus. Graefe's Arch Clin Exp Ophthalmol. 1950;150:385-387.
29. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003;23: 10691-10702.
30. Moore RY, Eichler B. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 1972;42:201-206.
31. Cascio CS, Shinsako J, Dallman MF. The suprachiasmatic nuclei stimulate evening ACTH secretion in the rat. Brain Res. 1987; 423:173-178.
32. Stephan FK, Zucker I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci U S A. 1972;69:1583-1586.
33. Schwartz WJ, Gainer H. Suprachiasmatic nucleus: use of 14Clabeled deoxyglucose uptake as a functional marker. Science. 1977;197:1089-1091.
34. Mouret J, Coindet J, Debilly G, Chouvet G. Suprachiasmatic nuclei lesions in the rat: alterations in sleep circadian rhythms. Electroenceph Clin Neurophysiol. 1978;45:402-408.
35. Inouye ST, Kawamura H. Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus. Proc Natl Acad Sci U S A. 1979;76: 5962-5966.
36. ter Horst GJ, Luiten PG. The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res Bull. 1986;16:231-248.
37. Kusaka G, Calvert JW, Smelley C, Nanda A, Zhang JH. New lumbar method for monitoring cerebrospinal fluid pressure in rats. J Neurosci Methods. 2004;135:121-127.
38. Samuels BC, Zaretsky DV, DiMicco JA. Dorsomedial hypothalamic sites where disinhibition evokes tachycardia correlate with location of raphe-projecting neurons. Am J Physiol Regul Integr Comp Physiol. 2004;287:R472-R478.
39. Samuels BC, Zaretsky DV, DiMicco JA. Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe. J Physiol (London). 2002;538:941-946.
40. Keim SR, Shekhar A. The effects of GABAA receptor blockaid in the dorsomedial hypothalamic nucleus on corticotrophin (ACTH) and corticosterone secretion in male rats. Brain Res. 1996;739:46-51.
41. Segura T, Martin DS, Sheridan PJ, Haywood JR. Measurement of the distribution of [3H]bicuculline microinjected into the rat hypothalamus. J Neurosci Methods. 1992;41:175-186.
42. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 6th ed. San Diego, CA: Academic Press; 1997.
43. Lassen NA. Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959;39:183-238.
44. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2:161-192.
45. Alperin N, Lee SH, Sivaramakrishnan A, Hushek SG. Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies. J Magn Reson Imaging. 2005; 22:591-596.
46. Morrow BA, Starcevic VP, Keil LC, Seve WB. Intracranial hypertension after cerebroventricular infusions in conscious rats. Am J Physiol. 1990;258(5 pt 2): R1170-R1176.
47. Starcevic VP, Morrow BA, Farner LA, Keil LC, Severs WB. Longterm recording of cerebrospinal fluid pressure in freely behaving rats. Brain Res. 1988;462:112-117.
48. Lin JS, Liu JH. Circadian variations in intracranial pressure and translaminar pressure difference in Sprague-Dawley rats. Invest Ophthalmol Vis Sci. 2010;51:5739-5743.
49. Roberts MD, Grau V, Grimm J, et al. Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2009;50:681-690.
50. Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Retin Eye Res. 2005;24:39-73.
51. Downs JC, Roberts MD, Burgoyne CF, Hart RT. Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4277-4280.
52. Morgan WH, Chauhan BC, Yu DY, Cringle SJ, Alder VA, House PH. Optic disc movement with variations in intraocular and cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci. 2002; 43:3236-3242.
53. Roberts MD, Liang Y, Sigal IA, et al. Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes. Invest Ophthalmol Vis Sci. 2010;51:295-307.
54. Schmerl E, Steinberg B. Central control of intraocular pressure by active principles. Am J Ophthalmol. 1948;3:1097-1101.
55. Schmerl E, Steinberg B. Separation of diencephalic centers concerned with pupillary motility and ocular tension. Am J Ophthalmol. 1950;33:1379-1380.
56. Gloster J, Greaves DP. Effect of diencephalic stimulation upon intraocular pressure. Br J Ophthalmol. 1957;41:513-532.
57. Grimes PA, Macri FJ, Von Sallmann L, Wanko T. Some mechanisms of centrally induced eye pressure responses. Am J Ophthalmol. 1956;42:130-147.
58. Bard A. A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system. Am J Physiol. 1928;84:490-515.
59. Hess RW. Diencephalon: autonomic and extrapyramidal functions. 1954; New York: Grune and Stratton. Original work in German: Hess WR, Brugger M. Das subkortikake Zenrrumder affektriven Abwehrreaktion. Helv Physiol Acta. 1943; 1:33-52.
60. Shekhar A, Sims LS, Bowsher RR. GABA receptors in the region of the dorsomedial hypothalamus of rats regulate anxiety in the elevated plus-maze test. II. Physiological measures. Brain Res. 1993;627:17-24.
61. DeNovellis V, Stotz-Potter EH, Morin SM, Rossi F, DiMicco JA. Hypothalamic sites mediating cardiovascular effects of microinjected bicuculline and EAAs in rats. Am J Physiol. 1995; 269(1 pt 2):R131-R140.
62. Zaretsky DV, Zaretskaia MV, Samuels BC, Cluxton LK, DiMicco JA. Microinjection of muscimol into raphe pallidus suppresses tachycardia associated with air stress in conscious rats. J Physiol. 2003;546:243-250.
63. Zaretskaia MV, Zaretsky DV, DiMicco JA. Role of the dorsomedial hypothalamus in thermogenesis and tachycardia caused by microinjection of prostaglandin E2 into the preoptic area in anesthetized rats. Neurosci Lett. 2003;340: 1-4.
64. Madden CJ, Morrison SF. Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue. Am J Physiol Reg Int Comp Physiol. 2004;286:R320-R325.
65. Stotz-Potter EH, Morin SM, DiMicco JA. Effect of microinjection of muscimol into the dorsomedial or paraventricular nucleus on air stress-induced neuroendocrine and cardiovascular changes in rats. Brain Res. 1996;742:219-224.
66. Goodchild AK, Dampney RA, Bandler R. A method for evoking physiological responses by stimulation of cell bodies, but not axons of passage, within localized regions of the central nervous system. J Neurosci Methods. 1982;6:351-363.
67. Sadun AA, Schaechter JD, Smith LE. A retinohypothalamic pathway in man: light mediation of circadian rhythms. Brain Res. 1984;302:371-377.
68. Sollars PJ, Smeraski CA, Kaufman JD, Ogilvie MD, Provencio I, Pickard GE. Melanopsin and non-melanopsin expressing retinal ganglion cells innervate the hypothalamic suprachiasmatic nucleus. Vis Neurosci. 2003;20:601-610.
69. Morin LP, Blanchard JH, Provencio I. Retinal ganglion cell projections to the hamster suprachiasmatic nucleus, intergeniculate leaflet, and visual midbrain: bifurcation and melanopsin immunoreactivity. J Comp Neurol. 2003;465: 401-416.
70. Hattar S, Kumar M, Park A, et al. Central projections of melanopsin-expressing retinal ganglion cells in the mouse. J Comp Neurol. 2006;497:326-349.
71. Wilensky JT. Diurnal variations in IOP. Trans Am Ophthalmol Soc. 1991;89:757-790.
72. Liu JH, Kripke DF, Twa MD, et al. Twenty-four hour pattern of IOP in the aging population. Invest Ophthal Vis Sci. 1999;40: 2912-2917.
73. Liu JH, Zhang X, Kripke DF, Weinreb RN. Twenty-four hour IOP pattern associated with early glaucomatous changes. Invest Ophthal Vis Sci. 2003;44:1586-1590.
74. Valderrama CM, Li R, Liu JH. Direct effect of light on twentyfour hour variation of aqueous humor protein concentration in Sprague-Dawley rats. Exp Eye Res. 2008;87:487-491.
75. Liu JH, Shieh BE. Suprachiasmatic nucleus in the neural circuitry for the circadian elevation of IOP in rabbits. J Ocul Pharmacol Ther. 1995;11:379-388.
76. Bernardis LL, Bellinger LL. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc Soc Exp Biol Med. 1998; 218:284-306.
77. Gooley JJ, Schomer A, Saper CB. The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat Neurosci. 2006;9:398-407.
78. Sallanon M, Denoyer M, Kitahama K, Aubert C, Gay N, Jouvet M. Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat. Neurosci. 1989;32:669-683.
79. Abrahamson EE, Leak RK, Moore RY. The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems. NeuroReport. 2001;12:435-440.
80. Watts AG, Swanson LW, Sanchez-Watts G. Efferent projections of the suprachiasmatic nucleus: I. Studies using anterograde transport of Phaseolus vulgaris leucoagglutinin in the rat. J Comp Neurol. 1987;258:204-229.
81. Kalsbeek A, Teclemariam-Mesbah R, Pevet P. Efferent projections of the suprachiasmatic nucleus in the golden hamster (Mesocricetus auratus). J Comp Neurol. 1993;332: 293-314.
82. Morin LP, Goodless-Sanchez N, Smale L, Moore RY. Projections of the suprachiasmatic nuclei, subparaventricular zone and retrochiasmatic area in the golden hamster. Neuroscience. 1994;61:391-410.