KPC-4 is encoded within a truncated Tn4401 in an IncL/M plasmid, pNE1280, isolated from Enterobacter cloacae and Serratia marcescens

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 1, 2013, Pages 37-41

  Bryant, Kendall A ^a   Van Schooneveld, Trevor C ^a   Thapa, Ishwor ^b   Bastola, Dhundy ^b   Williams, Laurina O ^c   Safranek, Thomas J ^d   Hinrichs, Steven H ^a   Rupp, Mark E ^a   Fey, Paul D ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d Nebraska Department of Health and Human Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; BACTERIAL ENZYME; BACTERIAL PROTEIN; CARBAPENEMASE; CEFEPIME; CEFOXITIN; CIPROFLOXACIN; ERTAPENEM; IMIPENEM; ISKPN7 PROTEIN; KLEBSIELLA PNEUMONIAE CARBAPENEMASE 4 PROTEIN; MEROPENEM; TNPA PROTEIN; TNPR PROTEIN; UNCLASSIFIED DRUG;

ACALCULOUS CHOLECYSTITIS; ADULT; AORTA VALVE REPLACEMENT; ARTICLE; BACTERIAL GENE; CASE REPORT; DNA SEQUENCE; DYSPNEA; ENTEROBACTER CLOACAE; ENZYME ISOLATION; FEMALE; GALLBLADDER DRAINAGE; GENE EXPRESSION; GENETIC CONSERVATION; HEMICOLECTOMY; HEMODIALYSIS; HUMAN; ISCHEMIC COLITIS; KIDNEY FAILURE; LUNG LAVAGE; MINIMUM INHIBITORY CONCENTRATION; MITRAL VALVE REPLACEMENT; NONHUMAN; PALLIATIVE THERAPY; PLASMID; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SERRATIA MARCESCENS; SURGICAL INFECTION; TRANSPOSON;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; COINFECTION; DNA TRANSPOSABLE ELEMENTS; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE INFECTIONS; FATAL OUTCOME; FEMALE; GENE TRANSFER, HORIZONTAL; HUMANS; MIDDLE AGED; PLASMIDS; SEQUENCE ANALYSIS, DNA; SERRATIA INFECTIONS; SERRATIA MARCESCENS;

EID: 84872023647     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01062-12     Document Type: Article

References (32)

1. Gupta N, Limbago BM, Patel JB, Kallen AJ. 2011. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin. Infect. Dis. 53:60-67.
2. KPC-2 gene. Emerg. Infect. Dis. 16:1349-1356.
3. Kitchel B, Rasheed JK, Patel JB, Srinivasan A, Navon-Venezia S, Carmeli Y, Brolund A, Giske CG. 2009. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob. Agents Chemother. 53:3365-3370.
4. Cai JC, Zhou HW, Zhang R, Chen GX. 2008. Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. Antimicrob. Agents Chemother. 52:2014-2018.
5. Marchaim D, Navon-Venezia S, Schwaber MJ, Carmeli Y. 2008. Isolation of imipenem-resistant Enterobacter species: emergence of KPC-2 carbapenemase, molecular characterization, epidemiology, and outcomes. Antimicrob. Agents Chemother. 52:1413-1418.
6. Mathers AJ, Cox HL, Kitchel B, Bonatti H, Brassinga AK, Carroll J, Scheld WM, Hazen KC, Sifri CD. 2011. Molecular dissection of an outbreak of carbapenem-resistant Enterobacteriaceae reveals intergenus KPC carbapenemase transmission through a promiscuous plasmid. mBio 2:e00204-11. doi:10.1128/mBio.00204-11.
7. Garcia-Fernandez A, Villa L, Carta C, Venditti C, Giordano A, Venditti M, Mancini C, Carattoli A. 2012. Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin variants. Antimicrob. Agents Chemother. 56:2143-2145.
8. Goren MG, Carmeli Y, Schwaber MJ, Chmelnitsky I, Schechner V, Navon-Venezia S. 2010. Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient. Emerg. Infect. Dis. 16:1014-1017.
9. Mataseje LF, Boyd DA, Willey BM, Prayitno N, Kreiswirth N, Gelosia A, Poutanen SM, Low DE, Jenkins SG, Katz K, Mulvey MR. 2011. Plasmid comparison and molecular analysis of Klebsiella pneumoniae harbouring bla(KPC) from New York City and Toronto. J. Antimicrob. Chemother. 66:1273-1277.
10. Sidjabat HE, Silveira FP, Potoski BA, Abu-Elmagd KM, Adams-Haduch JM, Paterson DL, Doi Y. 2009. Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient. Clin. Infect. Dis. 49:1736-1738.
11. KPC from Tn4401 in carbapenem-resistant Klebsiella pneumoniae. Antimicrob. Agents Chemother. 56:1635-1638.
12. Kitchel B, Rasheed JK, Endimiani A, Hujer AM, Anderson KF, Bonomo RA, Patel JB. 2010. Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 54:4201-4207.
13. KPC gene expression. Antimicrob. Agents Chemother. 56:4753-4759.
14. Naas T, Cuzon G, Villegas MV, Lartigue MF, Quinn JP, Nordmann P. 2008. Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. Antimicrob. Agents Chemother. 52:1257-1263.
15. Zhu WH, Luo L, Wang JY, Zhuang XH, Zhong L, Liao K, Zeng Y, Lu YJ. 2009. Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug-resistant Klebsiella pneumoniae strain isolated in China. Antimicrob. Agents Chemother. 53:5291-5293.
16. Clinical Laboratory Standards Institute. 2012. Performance standards for antimicrobial disk susceptibility tests; approved standard M02-A11, vol 32. Clinical and Laboratory Standards Institute, Wayne, PA.
17. Clinical Laboratory Standards Institute. 2012. Performance standards for antimicrobial susceptibility testing: twenty-second informational supplement M100-S22, vol 32. Clinical and Laboratory Standards Institute, Wayne, PA.
18. Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ. 2005. Identification of plasmids by PCR-based replicon typing. J. Microbiol. Methods 63:219-228.
19. Queenan AM, Bush K. 2007. Carbapenemases: the versatile beta-lactamases. Clin. Microbiol. Rev. 20:440-458.
20. Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, Alberti S, Bush K, Tenover FC. 2001. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 45:1151-1161.
21. Mathew A, Harris AM, Marshall MJ, Ross GW. 1975. The use of analytical isoelectric focusing for detection and identification of beta-lactamases. J. Gen. Microbiol. 88:169-178.
22. Ribot EM, Fair MA, Gautom R, Cameron DN, Hunter SB, Swaminathan B, Barrett TJ. 2006. Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Path. Dis. 3:59-67.
23. Sambrook JE, Maniatis T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
24. Kado CI, Liu ST. 1981. Rapid procedure for detection and isolation of large and small plasmids. J. Bacteriol. 145:1365-1373.
25. Jacoby GA, Han P. 1996. Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J. Clin. Microbiol. 34:908-911.
26. Yi H, Cho YJ, Yong D, Chun J. 2012. Genome sequence of Escherichia coli J53, a reference strain for genetic studies. J. Bacteriol. 194:3742-3743.
27. Cantarel BL, Korf I, Robb SM, Parra G, Ross E, Moore B, Holt C, Sanchez Alvarado A, Yandell M. 2008. MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes. Genome Res. 18:188-196.
28. Wolter DJ, Kurpiel PM, Woodford N, Palepou MF, Goering RV, Hanson ND. 2009. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. Antimicrob. Agents Chemother. 53:557-562.
29. CMY-2 from multiple Salmonella plasmid backbones. Antimicrob. Agents Chemother. 48:2845-2852.
30. Woodford N, Tierno PM, Jr, Young K, Tysall L, Palepou MF, Ward E, Painter RE, Suber DF, Shungu D, Silver LL, Inglima K, Kornblum J, Livermore DM. 2004. Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center. Antimicrob. Agents Chemother. 48:4793-4799.
31. KPC gene mobilization. Antimicrob. Agents Chemother. 55:5370-5373.
32. KPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil. Antimicrob. Agents Chemother. 55:3579-3583.