Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement

Angle Orthodontist

Volumn 83, Issue 1, 2013, Pages 48-56

  Usumi Fujita, Risa ^a   Hosomichi, Jun ^a   Ono, Noriaki ^a   Shibutani, Naoki ^a   Kaneko, Sawa ^a   Shimizu, Yasuhiro ^a   Ono, Takashi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Occlusal hypofunction; Tooth movement; VEGF; VEGFR

Indexed keywords

VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANIMAL; ARTICLE; COMPARATIVE STUDY; CONGENITAL MALFORMATION; IMMUNOHISTOCHEMISTRY; MALE; MALOCCLUSION; MECHANICAL STRESS; METABOLISM; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; MOLAR TOOTH; NICK END LABELING; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; RAT; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MALOCCLUSION; MOLAR; PERIODONTAL ATROPHY; PERIODONTAL LIGAMENT; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TOOTH MOVEMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; X-RAY MICROTOMOGRAPHY;

EID: 84872008720     PISSN: 00033219     EISSN: 19457103     Source Type: Journal    
DOI: 10.2319/011712-45.1     Document Type: Article

References (23)

1. Esashika M, Kaneko S, Yanagishita M, Soma K. Influence of orthodontic forces on the distribution of proteoglycans in rat hypofunctional periodontal ligament. J Med Dent Sci. 2003; 50:183-194.
2. Sringkarnboriboon S, Matsumoto Y, Soma K. Root resorption related to hypofunctional periodontium in experimental tooth movement. J Dent Res. 2003;82:486-490.
3. Harris EF, Butler ML. Patterns of incisor root resorption before and after orthodontic correction in cases with anterior open bites. Am J Orthod Dentofacial Orthop. 1992;101: 112-119.
4. Fuss Z, Tsesis I, Lin S. Root resorption-diagnosis, classification and treatment choices based on stimulation factors. Dent Traumatol. 2003;19:175-182.
5. Tanaka A, Iida J, Soma K. Effect of hypofunction on the microvasculature in the periodontal ligament of the rat molar. Orthodontic Waves. 1998;57:180-188.
6. Kaneko S, Ohashi K, Soma K, Yanagishita M. Occlusal hypofunction causes changes of proteoglycan content in the rat periodontal ligament. J Periodontal Res. 2001;36:9-17.
7. Watarai H, Warita H, Soma K. Effect of nitric oxide on the recovery of the hypofunctional periodontal ligament. J Dent Res. 2004;83:338-342.
8. Proffit W. The biological basis of orthodontic therapy. Contemporary Orthodontics. Mosby, St. Louis, MO. 2007: 334-339.
9. Miyagawa A, Chiba M, Hayashi H, Igarashi K. Compressive force induces VEGF production in periodontal tissues. J Dent Res. 2009;88:752-756.
10. Niida S, Kaku M, Amano H, et al. Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med. 1999;190:293-298.
11. Nakagawa M, Kaneda T, Arakawa T, et al. Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett. 2000;473:161-164.
12. Street J, Bao M, deGuzman L, et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A. 2002; 99:9656-9661.
13. Suhr E, Warita H, Iida J, Soma K. The effects of occlusal hypofunction and its recovery on the periodontal tissues of the rat molar: ED1 immunohistochemical study. Orthodontic Waves. 2002;61:165-172.
14. Kawamoto T. Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole-animals, insects and plants. Arch Histol Cytol. 2003; 66:123-143.
15. Nilforoushan D, Manolson MF. Expression of nitric oxide synthases in orthodontic tooth movement. Angle Orthod. 2009;79:502-508.
16. Kohno T, Matsumoto Y, Kanno Z, Warita H, Soma K. Experimental tooth movement under light orthodontic forces: Rates of tooth movement and changes of the periodontium. J Orthod. 2002;29:129-135.
17. Kohno S, Kaku M, Tsutsui K, et al. Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement. J Dent Res. 2003; 82:177-182.
18. Yoshino H, Morita I, Murota SI, Ishikawa I. Mechanical stress induces production of angiogenic regulators in cultured human gingival and periodontal ligament fibroblasts. J Periodontal Res. 2003;38:405-410.
19. Góth MI, Hubina E, Raptis S, Nagy GM, Tóth BE. Physiological and pathological angiogenesis in the endocrine system. Microsc Res Tech. 2003;60:98-106.
20. Kang SY, Watnick RS. Regulation of tumor dormancy as a function of tumor-mediated paracrine regulation of stromal Tsp-1 and VEGF expression. APMIS. 2008;116:638-647.
21. Leonard EC, Friedrich JL, Basile DP. VEGF-121 preserves renal microvessel structure and ameliorates secondary renal disease following acute kidney injury. Am J Physiol Renal Physiol. 2008;295:F1648-F1657.
22. Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM. Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke. 2010;41: 343-349.
23. Lee JH, Um S, Jang JH, Seo BM. Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells. Cell Tissue Res. 2012 Mar 23 [Epub ahead of print].