Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells

Cell and Tissue Research

Volumn 348, Issue 3, 2012, Pages 475-484

  Lee, Joo Hee ^a   Um, Soyoun ^a   Jang, Jun Hyeog ^b   Seo, Byoung Moo ^a,c  

^a Seoul National University   (South Korea)

^b Inha University School of Medicine   (South Korea)

^c BK 21 Plus   (South Korea)

Author keywords

Fibroblast growth factor 2; Odonto osteogenic differentiation .Vascular endothelial growth factor; Periodontal ligament stem cells; Tissue regeneration

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CALCIUM PHOSPHATE; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR 2; HYDROXYAPATITE; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX2; VASCULOTROPIN;

ALP GENE; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HISTOGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; RUNX2 GENE; STEM CELL; STEM CELL TRANSPLANTATION; TISSUE REGENERATION; TOOTH DEVELOPMENT; TYPE 1 COLLAGEN GENE; UPREGULATION;

ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; BONE MARROW CELLS; CALCIUM PHOSPHATES; CELL DIFFERENTIATION; CELL PROLIFERATION; DURAPATITE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; OSTEOGENESIS; PERIODONTAL LIGAMENT; REGENERATION; RNA, MESSENGER; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS MUSCULUS;

EID: 84866307899     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-012-1392-x     Document Type: Article

References (30)

1. Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG (2006) Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone 38:758-768
2. Canalis E, Centrella M, McCarthy T (1988) Effects of basic fibroblast growth factor on bone formation in vitro. J Clin Invest 81:1572-1577
3. Chaudhary LR, Hofmeister AM, Hruska KA (2004) Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone 34:402-411
4. Dangaria SJ, Ito Y, Walker C, Druzinsky R, Luan X, Diekwisch TG (2009) Extracellular matrix-mediated differentiation of periodontal progenitor cells. Differentiation 78:79-90
5. Fakhry A, Ratisoontorn C, Vedhachalam C, Salhab I, Koyama E, Leboy P, Pacifici M, Kirschner RE, Nah HD (2005) Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. Bone 36:254-266
6. Ferrara N, Davis-Smyth T (1997) The biology of vascular endothelial growth factor. Endocr Rev 18:4-25
7. Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK (2003) Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res 93:e88-e97
8. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630
9. Hakki SS, Hakki EE, Nohutcu RM (2009) Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells. J Periodontal Res 44:794-802
10. Hiltunen MO, Ruuskanen M, Huuskonen J, Mahonen AJ, Ahonen M, Rutanen J, Kosma VM, Mahonen A, Kroger H, Yla-Herttuala S (2003) Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB J 17:1147-1149
11. Huang Z, Ren PG, Ma T, Smith RL, Goodman SB (2010) Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability. Cytokine 51:305-310
12. Ito T, Sawada R, Fujiwara Y, Tsuchiya T (2008) FGF-2 increases osteogenic and chondrogenic differentiation potentials of human mesenchymal stem cells by inactivation of TGF-beta signaling. Cytotechnology 56:1-7
13. Jacobsen KA, Al-Aql ZS, Wan C, Fitch JL, Stapleton SN, Mason ZD, Cole RM, Gilbert SR, Clemens TL, Morgan EF, Einhorn TA, Gerstenfeld LC (2008) Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling. J Bone Miner Res 23:596-609
14. Karsenty G, Wagner EF (2002) Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2:389-406
15. Maegawa N, Kawamura K, Hirose M, Yajima H, Takakura Y, Ohgushi H (2007) Enhancement of osteoblastic differentiation of mesenchymal stromal cells cultured by selective combination of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2). J Tissue Eng Regen Med 1:306-313
16. Martin I, Muraglia A, Campanile G, Cancedda R, Quarto R (1997) Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138:4456-4462
17. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S (2003) SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 100:5807-5812
18. Muruganandan S, Roman AA, Sinal CJ (2009) Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci 66:236-253
19. Ogston N, Harrison AJ, Cheung HF, Ashton BA, Hampson G (2002) Dexamethasone and retinoic acid differentially regulate growth and differentiation in an immortalised human clonal bone marrow stromal cell line with osteoblastic characteristics. Steroids 67:895-906
20. Osyczka AM, Damek-Poprawa M, Wojtowicz A, Akintoye SO (2009) Age and skeletal sites affect BMP-2 responsiveness of human bone marrow stromal cells. Connect Tissue Res 50:270-277
21. Powers CJ, McLeskey SW, Wellstein A (2000) Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 7:165-197
22. Qu D, Li J, Li Y, Gao Y, Zuo Y, Hsu Y, Hu J (2011) Angiogenesis and osteogenesis enhanced by bFGF ex vivo gene therapy for bone tissue engineering in reconstruction of calvarial defects. J Biomed Mater Res A 96:543-551
23. Quarto N, Longaker MT (2006) FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state. Tissue Eng 12:1405-1418
24. Schipani E, Maes C, Carmeliet G, Semenza GL (2009) Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res 24:1347-1353
25. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149-155
26. Shoji T, Ii M, Mifune Y, Matsumoto T, Kawamoto A, Kwon SM, Kuroda T, Kuroda R, Kurosaka M, Asahara T (2010) Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis. Lab Invest 90:637-649
27. Song SY, Chung HM, Sung JH (2010) The pivotal role of VEGF in adipose-derived-stem-cell-mediated regeneration. Expert Opin Biol Ther 10:1529-1537
28. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H, Gronthos S, Wang CY, Wang S, Shi S (2006) Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 1:e79
29. Xiao L, Sobue T, Esliger A, Kronenberg MS, Coffin JD, Doetschman T, Hurley MM (2010) Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone 47:360-370
30. Yun YR, Won JE, Jeon E, Lee S, Kang W, Jo H, Jang JH, Shin US, Kim HW (2010) Fibroblast growth factors: biology, function, and application for tissue regeneration. J Tissue Eng 2010:218142