Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes

Journal of Leukocyte Biology

Volumn 93, Issue 1, 2013, Pages 155-160

  Aurelius, Johan ^a   Martner, Anna ^a   Riise, Rebecca E ^a   Romero, Ana I ^a   Palmqvist, Lars ^a   Brune, Mats ^a   Hellstrand, Kristoffer ^a   Thorén, Fredrik B ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Immunosuppression; NK cells; PARP 1; Reactive oxygen species

Indexed keywords

BCR ABL PROTEIN; EB 47; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

CANCER PATIENT; CELL DEATH; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; COCULTURE; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DEGRANULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOMODULATION; LEUKEMIA CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE INACTIVATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOTOXICITY; NATURAL KILLER CELL; PRIORITY JOURNAL; REVIEW; TUMOR IMMUNITY;

CELL DEATH; COCULTURE TECHNIQUES; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; KILLER CELLS, NATURAL; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES;

EID: 84871985329     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0512257     Document Type: Review

References (24)

1. Teichmann, J. V., Ludwig, W. D., Thiel, E. (1992) Susceptibility of human leukemia to allogeneic and autologous lymphokine-activated killer cell activity: analysis of 252 samples. Nat. Immun. 11, 117-132.
2. Cervantes, F., Pierson, B. A., McGlave, P. B., Verfaillie, C. M., Miller, J. S. (1996) Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture. Blood 87, 2476-2485.
3. Butt, N. M., Rojas, J. M., Wang, L., Christmas, S. E., Abu-Eisha, H. M., Clark, R. E. (2005) Circulating bcr-abl-specific CD8+ T cells in chronic myeloid leukemia patients and healthy subjects. Haematologica 90, 1315-1323.
4. Chen, C. I., Koschmieder, S., Kerstiens, L., Schemionek, M., Altvater, B., Pscherer, S., Gerss, J., Maecker, H. T., Berdel, W. E., Juergens, H., Lee, P. P., Rossig, C. (2012) NK cells are dysfunctional in human chronic myelogenous leukemia before and on Imatinib treatment and in BCRABL- positive mice. Leukemia 26, 465-474.
5. Pierson, B. A., Miller, J. S. (1996) CD56+bright and CD56+dim natural killer cells in patients with chronic myelogenous leukemia progressively decrease in number, respond less to stimuli that recruit clonogenic natural killer cells, and exhibit decreased proliferation on a per cell basis. Blood 88, 2279-2287.
6. Chen, X., Woiciechowsky, A., Raffegerst, S., Schendel, D., Kolb, H. J., Roskrow, M. (2000) Impaired expression of the CD3-ξ chain in peripheral blood T cells of patients with chronic myeloid leukaemia results in an increased susceptibility to apoptosis. Br. J. Haematol. 111, 817-825.
7. Mahon, F-X., Rea, D., Guilhot, F., Huguet, F., Nicolini, F. E., Legros, L., Charbonnier, A., Guerci, A., Varet, B. R., Etienne, G., Aton, E., Reiffers, J., Rousselot, P. (2009) Discontinuation of Imatinib therapy after achieving a molecular response in chronic myeloid leukemia patients. 51st American Society of Hematology Annual Meeting and Exposition Online Program and Abstracts, New Orleans, LA, USA.
8. Aurelius, J., Thorén, F. B., Akhiani, A., Brune, M., Palmqvist, L., Hansson, M., Hellstrand, K., Martner, A. (2012) Monocytic AML cells inactivate anti-leukemic lymphocytes: role of NADPH oxidase/gp91phox expression and the PARP-1/PAR pathway of apoptosis. Blood 119, 5832-5837.
9. Mellqvist, U. H., Hansson, M., Brune, M., Dahlgren, C., Hermodsson, S., Hellstrand, K. (2000) Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. Blood 96, 1961-1968.
10. Schmielau, J., Finn, O. J. (2001) Activated granulocytes and granulocytederived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 61, 4756-4760.
11. Gabrilovich, D. I., Ostrand-Rosenberg, S., Bronte, V. (2012) Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253-268.
12. Thoren, F. B., Romero, A. I., Hellstrand, K. (2006) Oxygen radicals induce poly(ADP-ribose) polymerase-dependent cell death in cytotoxic lymphocytes. J. Immunol. 176, 7301-7307.
13. Durkacz, B. W., Omidiji, O., Gray, D. A., Shall, S. (1980) (ADP-ribose)n participates in DNA excision repair. Nature 283, 593-596.
14. Yu, S. W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., Dawson, V. L. (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297, 259-263.
15. Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., Gottlieb, E., Green, D. R., Hengartner, M. O., Kepp, O., Knight, R. A., Kumar, S., Lipton, S. A., Lu, X., Madeo, F., Malorni, W., Mehlen, P., Nunez, G., Peter, M. E., Piacentini, M., Rubinsztein, D. C., Shi, Y., Simon, H. U., Vandenabeele, P., White, E., Yuan, J., Zhivotovsky, B., Melino, G., Kroemer, G. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 19, 107-120.
16. Dahlgren, C., Karlsson, A. (1999) Respiratory burst in human neutrophils. J. Immunol. Methods 232, 3-14.
17. Thoren, F. B., Betten, A., Romero, A. I., Hellstrand, K. (2007) Cutting edge: antioxidative properties of myeloid dendritic cells: protection of T cells and NK cells from oxygen radical-induced inactivation and apoptosis. J. Immunol. 179, 21-25.
18. Betts, M. R., Brenchley, J. M., Price, D. A., De Rosa, S. C., Douek, D. C., Roederer, M., Koup, R. A. (2003) Sensitive and viable identification of antigen-specific CD8_ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281, 65-78.
19. Asemissen, A. M., Scheibenbogen, C., Letsch, A., Hellstrand, K., Thoren, F., Gehlsen, K., Schmittel, A., Thiel, E., Keilholz, U. (2005) Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP 104). Clin. Cancer Res. 11, 290-297.
20. Babior, B. M. (1999) NADPH oxidase: an update. Blood 93, 1464-1476.
21. Marklund, S. L., Westman, N. G., Lundgren, E., Roos, G. (1982) Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res. 42, 1955-1961.
22. Lozzio, C. B., Lozzio, B. B. (1975) Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45, 321-334.
23. Shall, S., de Murcia, G. (2000) Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat. Res. 460, 1-15.
24. Kraus, W. L., Lis, J. T. (2003) PARP goes transcription. Cell 113, 677-683.