The biochemistry of love: An oxytocin hypothesis

EMBO Reports

Volumn 14, Issue 1, 2013, Pages 12-16

  Carter, C Sue ^a   Porges, Stephen W ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; OXYTOCIN; OXYTOCIN RECEPTOR; VASOPRESSIN; VASOPRESSIN ANTAGONIST; VASOPRESSIN RECEPTOR;

ADULTHOOD; AGGRESSION; ANXIETY; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BIOCHEMISTRY; BREAST FEEDING; CESAREAN SECTION; CHILD CARE; COGNITION; COPING BEHAVIOR; EMOTION; EPIGENETICS; EXPERIENCE; HUMAN; HUMAN RELATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IN VITRO STUDY; INJURY; LIFE STRESS; LOVE; MENTAL HEALTH; NEGLECT; NEUROBIOLOGY; NEUROENDOCRINE SYSTEM; NONHUMAN; PARENTAL BEHAVIOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY SYSTEM; SOCIAL BEHAVIOR; SOCIAL COGNITION; SOCIAL INTERACTION; SOCIAL ISOLATION; SOCIAL STRESS; SOCIAL SUPPORT; SOCIETY; SYSTEMS BIOLOGY; WELLBEING;

FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION; HEART; HUMANS; LOVE; MALE; MENTAL HEALTH; OXYTOCIN; RECEPTORS, OXYTOCIN; SEX; SEXUAL BEHAVIOR; SOCIAL DISTANCE; STRESS, PHYSIOLOGICAL; VASOPRESSINS;

EID: 84871923330     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2012.191     Document Type: Article

References (25)

1. Ingham CJ, Ben Jacob E (2008) Swarming and complex pattern formation in Paenicbachillus vortex studied by imaging and tracking cells. BMC Microbiol 8: 36
2. Woodward SH, Fischman BJ, Venkat A, Hudson ME, Varala K, Cameron SA, Clark AG, Robinson GE (2011) Genes involved in convergent evolution of eusociality in bees. Proc Natl Acad Sci USA 108: 7472-7477
3. Keverne EB (2006) Neurobiological and molecular approaches to attachment and bonding. In Attachment and Bonding: A New Synthesis (eds Carter CS, Ahnert L, Grossman KE, Hrdy SB, Lamb ME, Porges SW, Sachser N), pp 101-117. Cambridge, Massachusetts, USA: MIT Press
4. Feldman R (2012) Oxytocin and social affiliation in humans. Horm Behav 61: 380-391
5. Kenkel WM, Paredes J, Yee JR, Pournajafi-Nazarloo H, Bales KL, Carter CS (2012) Neuroendrocrine and behavioural responses to exposure to an infant in male prairie voles. J Neuroendocrinol 24: 874-886
6. Carter CS (1998) Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 23: 779-818
7. Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12: 524-538
8. Carter CS, Boone EM, Pournajafi-Nazarloo H, Bales KL (2009) Consequences of early experiences and exposure to oxytocin and vasopressin are sexually dimorphic. Dev Neurosci 31: 332-341
9. Aragona BJ, Wang Z (2009) Dopamine regulation of social choice in a monogamous rodent species. Front Behav Neurosci 3: 15
10. Cho MM, DeVries AC, Williams JR, Carter CS (1999) The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster). Behav Neurosci 113: 1071-1080
11. Bales KL, Kim AJ, Lewis-Reese AD, Carter CS (2004) Both oxytocin and vasopressin may influence alloparental care in male prairie voles. Horm Behav 44: 354-361 (Pubitemid 38520796)
12. Ferris CF (2008) Functional magnetic resonance imaging and the neurobiology of vasopressin and oxytocin. Prog Brain Res 170: 305-320 (Pubitemid 352010237)
13. Bosch OJ, Neumann ID (2012) Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action. Horm Behav 61: 293-303
14. Carter CS, DeVries AC, Getz LL (1995) Physiological substrates of mammalian monogamy: the prairie vole model. Neurosci Biobehav Rev 19: 303-314
15. Carter CS, Altemus M (1997) Integrative functions of lactational hormones in social behaviour and stress management. Ann NY Acad Sci 807: 164-174 (Pubitemid 27135491)
16. DeVries AC, DeVries MB, Taymans SE, Carter CS (1996) The effects of stress on social preferences are sexually dimorphic in prairie voles. Proc Natl Acad Sci USA 93: 11980-11984 (Pubitemid 26347234)
17. Zhang TY, Meaney MJ (2010) Epigenetics and the environmental regulation of the genome and its function. Annu Rev Psychol 61: 439-466
18. Zhang L, Hernandez VS, Liu B, Medina MP, Nava-Kopp AT, Irles C, Morales M (2012) Hypothalamic vasopressin system regulation by maternal separation: its impact on anxiety in rats. Neuroscience 215: 135-148
19. Connelly J, Kenkel W, Erickson E, Carter C (2011) Are birth and oxytocin epigenetic events? In Scientific Sessions Listings of Neuroscience 2011, p
20. Washington, DC, USA: Society of Neuroscience; Abstract 388.10
21. Grippo AJ, Trahanas DM, Zimmerman RR 2nd, Porges SW, Carter CS (2009) Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation. Psychoneuroendocrinology 34: 1542-1553
22. Porges SW (2011) The Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication and Self-regulation. New York, New York, USA: WW Norton
23. Karelina K, DeVries AC (2011) Modeling social influences on human health. Psychosom Med 73: 67-74
24. Danalache BA, Gutkowska J, Slusarz MJ, Berezowska I, Jankowski M (2010) Oxytocin Gly Lys-Arg: a novel cardiomyogenic peptide. PLoS ONE 5: e13643
25. Szeto A, Nation DA, Mendez AJ, Dominguez-Bendala J, Brooks LG, Schneiderman N, McCabe PM (2008) Oxytocin attenuates NADPH-dependent superoxide activity and IL6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab 295: E1495-E1501