Characterization of nitrotyrosine as a biomarker for arthritis and joint injury

Osteoarthritis and Cartilage

Volumn 21, Issue 1, 2013, Pages 151-156

  Misko, T P ^a   Radabaugh, M R ^a   Highkin, M ^a   Abrams, M ^a   Friese, O ^a   Gallavan, R ^a   Bramson, C ^a   Hellio Le Graverand, M P ^a   Lohmander, L S ^b,c   Roman, D ^a  

^a PFIZER INC   (United States)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Arthritis; Biomarkers; Joint injury; Nitric oxide; Nitrotyrosine

Indexed keywords

3 NITROTYROSINE; ADALIMUMAB; AGGRECAN; AGGRECANASE; C REACTIVE PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN TYPE 2; ETANERCEPT; GAMMA INTERFERON; GELATINASE B; INFLIXIMAB; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; INTERLEUKIN 9; INTERSTITIAL COLLAGENASE; NITRATE; NITRITE; RANTES; STROMELYSIN; TRANSFORMING GROWTH FACTOR ALPHA;

ANTERIOR CRUCIATE LIGAMENT INJURY; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; KNEE MENISCUS RUPTURE; KNEE PAIN; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSEUDOGOUT; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SYNOVIAL FLUID; TREATMENT RESPONSE; URINALYSIS;

ANTERIOR CRUCIATE LIGAMENT; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CHEMOKINES; CHONDROCALCINOSIS; CYTOKINES; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASES, SECRETED; MENISCI, TIBIAL; NITRATES; OSTEOARTHRITIS, KNEE; SYNOVIAL FLUID; TYROSINE;

EID: 84871921861     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.09.005     Document Type: Article

References (28)

1. Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007, 87:315-424.
2. Loeser R.F., Carlson C.S., Del Carlo M., Cole A. Detection of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin-1 beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum 2002, 46:2349-2357.
3. Mapp P.I., Klocke R., Walsh D.A., Chana J.K., Stevens C.R., Gallagher P.J., et al. Localization of 3-nitrotyrosine to rheumatoid and normal synovium. Arthritis Rheum 2001, 44:1534-1539.
4. Melchiorri C., Meliconi R., Frizziero L., Silvestri T., Pulsatelli L., Mazzetti I., et al. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 1998, 41:2165-2174.
5. Sakurai H., Kohsaka H., Liu M.F., Higashiyama H., Hirata Y., Kanno K., et al. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest 1995, 96:2357-2363.
6. Sandhu J.K., Robertson S., Birnboim H.C., Goldstein R. Distribution of protein nitrotyrosine in synovial tissues of patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 2003, 30:1173-1181.
7. Choi J.W. Nitric oxide production is increased in patients with rheumatoid arthritis but does not correlate with laboratory parameters of disease activity. Clin Chim Acta 2003, 336:83-87.
8. Farrell A.J., Blake D.R., Palmer R.M., Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992, 51:1219-1222.
9. Karan A., Karan M.A., Vural P., Erten N., Tascioglu C., Aksoy C., et al. Synovial fluid nitric oxide levels in patients with knee osteoarthritis. Clin Rheumatol 2003, 22:397-399.
10. Onur O., Akinci A.S., Akbiyik F., Unsal I. Elevated levels of nitrate in rheumatoid arthritis. Rheumatol Int 2001, 20:154-158.
11. Ueki Y., Miyake S., Tominaga Y., Eguchi K. Increased nitric oxide levels in patients with rheumatoid arthritis. J Rheumatol 1996, 23:230-236.
12. Weinberg J.B., Lang T., Wilkinson W.E., Pisetsky D.S., St Clair E.W. Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures. Arthritis Res Ther 2006, 8:R140.
13. Kaur H., Halliwell B. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett 1994, 350:9-12.
14. 2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage 2005, 13:258-265.
15. Lohmander L.S., Englund P.M., Dahl L.L., Roos E.M. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 2007, 35:1756-1769.
16. Larsson S., Lohmander L.S., Struglics A. Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study. Arthritis Res Ther 2009, 11:R92.
17. Lohmander L.S., Atley L.M., Pietka T.A., Eyre D.R. The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 2003, 48:3130-3139.
18. Lohmander L.S., Ionescu M., Jugessur H., Poole A.R. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum 1999, 42:534-544.
19. Lohmander L.S., Saxne T., Heinegard D. Increased concentrations of bone sialoprotein in joint fluid after knee injury. Ann Rheum Dis 1996, 55:622-626.
20. van der Heijde D.M., van't Hof M.A., van Riel P.L., Theunisse L.A., Lubberts E.W., van Leeuwen M.A., et al. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis 1990, 49:916-920.
21. Radabaugh M.R., Nemirovskiy O.V., Misko T.P., Aggarwal P., Mathews W.R. Immunoaffinity liquid chromatography-tandem mass spectrometry detection of nitrotyrosine in biological fluids: development of a clinically translatable biomarker. Anal Biochem 2008, 380:68-76.
22. Misko T.P., Schilling R.J., Salvemini D., Moore W.M., Currie M.G. A fluorometric assay for the measurement of nitrite in biological samples. Anal Biochem 1993, 214:11-16.
23. 2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2). Arthritis Rheum 1998, 41:2205-2210.
24. St Clair E.W., Wilkinson W.E., Lang T., Sanders L., Misukonis M.A., Gilkeson G.S., et al. Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients. J Exp Med 1996, 184:1173-1178.
25. Nemirovskiy O.V., Radabaugh M.R., Aggarwal P., Funckes-Shippy C.L., Mnich S.J., Meyer D.M., et al. Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: pharmacological dissection of iNOS' role in disease. Nitric Oxide 2009, 20:150-156.
26. Misko T.P., Highkin M.K., Veenhuizen A.W., Manning P.T., Stern M.K., Currie M.G., et al. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts. J Biol Chem 1998, 273:15646-15653.
27. Kraus V.B., Burnett B., Coindreau J., Cottrell S., Eyre D., Gendreau M., et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 2011, 19:515-542.
28. den Broeder A.A., Joosten L.A., Saxne T., Heinegard D., Fenner H., Miltenburg A.M., et al. Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation. Ann Rheum Dis 2002, 61:311-318.