Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: Complexities of interpreting nitric oxide measures

Arthritis Research and Therapy

Volumn 8, Issue 5, 2006, Pages

  Weinberg, J Brice ^a,b   Lang, Thomas ^c   Wilkinson, William E ^b   Pisetsky, David S ^a,b   St Clair, E William ^b  

^a DURHAM VA MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CARBOHYDRATE DIET; CREATININE; FAT INTAKE; NITRIC OXIDE; PROTEIN INTAKE;

BLOOD; CARBOHYDRATE DIET; FAT INTAKE; FEMALE; HUMAN; LACRIMAL FLUID; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHARMACOKINETICS; PROTEIN INTAKE; RHEUMATOID ARTHRITIS; SALIVA; URINE;

ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CREATININE; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; SALIVA; TEARS;

EID: 37049028640     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2030     Document Type: Article

References (53)

1. Abramson SB, Amin AR, Clancy RM, Attur M: The role of nitric oxide in tissue destruction. Best Pract Res Clin Rheumatol 2001, 15 831-845.
2. Wallace JL: Nitric oxide as a regulator of inflammatory processes. Mem Inst Oswaldo Cruz 2005, 100:5-9.
3. Ialenti A, Moncada S, Di Rosa M: Modulation of adjuvantarthritis by endogenous nitric oxide. Br J Pharmacol 1993, 110:701-706.
4. Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH: N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum 1994, 37:1062-1069.
5. McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie QW, Nathan CF, Wahl SM: Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993, 178:749-754.
6. Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, Tjoeng FS, Currie MG: Suppression of adjuvantinduced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 1995, 273:15-24.
7. Weinberg JB, Granger DL, Pisetsky DS, Seldin MF, Misukonis MA, Mason SN, Pippen AM, Ruiz P, Wood ER, Gilkeson GS: The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: Increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/ lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-l-arginine. J Exp Med 1994, 179:651-660.
8. McCartney-Francis NL, Song XY, Mizel DE, Wahl CL, Wahl SM: Hemoglobin protects from streptococcal cell wall-induced arthritis. Arthritis Rheum 1999, 42:1119-1127.
9. Weinberg JB: Nitric oxide and inflammation in autoimmune disorders In Cellular and Molecular Biology of Nitric Oxide Edited by: Laskin J, Laskin DL. New York: Marcel-Dekker; 1999:199-224.
10. Granger DL, Anstey NM, Miller WC, Weinberg JB: Measuring nitric oxide production in human clinical studies. Methods Enzymol 1999, 301:49-61.
11. Green LC, de Luzuriaga KR, Wagner DA, Rand W, Istfan N, Young VR, Tannenbaum SR: Nitrate biosynthesis in man. Proc Natl Acad Sci USA 1981, 78:7764-7768.
12. Jungersten L, Edlund A, Petersson AS, Wennmalm A: Plasmanitrate as an index of nitric oxide formation in man - analyses of kinetics and confounding factors. Clin Physiol 1996, 16:369-379.
13. Lundberg JO, Govoni M: Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 2004, 37:395-400.
14. Ueki Y, Miyake S, Tominaga Y, Eguchi K: Increased nitric oxide levels in patients with rheumatoid arthritis. J Rheumatol 1996, 23 230-236.
15. Grabowski PS, England AJ, Dykhuizen R, Copland M, Benjamin N, Reid DM, Ralston SH: Elevated nitric oxide production in rheumatoidarthritis - detection using the fasting urinary nitrate/creatinine ratio. Arthritis Rheum 1996, 39:643-647.
16. Kaur H, Halliwell B: Evidence for nitric oxide-mediated oxidative damage in chronic inflammation - nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett 1994, 350:9-12.
17. Farrell AJ, Blake DR, Palmer RM, Moncada S: Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992, 51:1219-1222.
18. Onur O, Akinci AS, Akbiyik F, Unsal I: Elevated levels of nitrate in rheumatoid arthritis. Rheumatol Int 2001, 20:154-158.
19. Pham TN, Rahman P, Tobin YM, Khraishi MM, Hamilton SF, Alderdice C, Richardson VJ: Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with coexpression of inducible nitric oxide synthase and protein kinase C-ε in peripheral blood monocyte-derived macrophages. J Rheumatol 2003, 30 2529-2534.
20. Choi JW: Nitric oxide production is increased in patients with rheumatoid arthritis but does not correlate with laboratory parameters of disease activity. Clin Chim Acta 2003, 336:83-87.
21. Ersoy Y, Ozerol E, Baysal O, Temel I, MacWalter RS, Meral U, Altay ZE: Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Ann Rheum Dis 2002, 61:76-78.
22. St Clair EW, Wilkinson WE, Lang T, Sanders L, Misukonis MA, Gilkeson GS, Pisetsky DS, Granger DL, Weinberg JB: Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients. J Exp Med 1996, 184:1173-1178.
23. Beckman JS, Chen J, Ischiropoulos H, Crow JP: Oxidative chemistry of peroxynitrite. Methods Enzymol 1994, 233:229-240.
24. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31:315-324.
25. Perkins DJ, St Clair EW, Misukonis MA, Weinberg JB: Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor α monoclonal antibody (cA2). Arthritis Rheum 1998, 41:2205-2210.
26. Pincus T, Summey JA, Soraci SA Jr, Wallston KA, Hummon NP: Assessment of patient satisfaction in activities of daily living using a modified Stanford Health Assessment Questionnaire. Arthritis Rheum 1983, 26:1346-1353.
27. Hochberg M, Chang RW, Dwosh I, Lindsey S, Pincus T, Wolfe F: The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum 1992, 35:498-502.
28. Meah MN, Harrison N, Davies A: Nitrate and nitrite in foods and the diet. Food Addit Contam 1994, 11:519-532.
29. Tarpey MM, Wink DA, Grisham MB: Methods for detection of reactive metabolites of oxygen and nitrogen: In vitro and in vivo considerations Am J Physiol Regul Integr Comp Physiol 2004, 286 R431-R444.
30. Granger DL, Anstey AM, Miller WC, Weinberg JB: Measuring nitric oxide production in human clinical studies. Methods Enzymol 1999, 301:49-61.
31. Bodis S, Haregewoin A: Evidence for the release and possible neural regulation of nitric oxide in human saliva. Biochem Biophys Res Commun 1993, 194:347-350.
32. van Bijsterveld OP: Diagnostic tests in the Sicca syndrome. Arch Ophthalmol 1969, 82:10-14.
33. Granger DL, Hibbs J Jr, Broadnax LM: Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine. J Immunol 1991, 146:1294-1302.
34. Pannala AS, Mani AR, Spencer JP, Skinner V, Bruckdorfer KR, Moore KP, Rice-Evans CA: The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 2003, 34:576-584.
35. Andonopoulos AP, Drosos AA, Skopouli FN, Moutsopoulos HM: Sjogren's syndrome in rheumatoid arthritis and progressive-systemic sclerosis. A comparative study. Clin Exp Rheumatol 1989, 7:203-205.
36. Averns H, Hall J, Webley M: Role of opticare eye drop delivery system in patients with rheumatoid arthritis. J Rheumatol 1999, 26 2615-2618.
37. Jensen JL, Uhlig T, Kvien TK, Axell T: Characteristics of rheumatoid arthritis patients with self-reported sicca symptoms: Evaluation of medical, salivary and oral parameters. Oral Dis 1997, 3 254-261.
38. Mody GM, Hill JC, Meyers OL: Keratoconjunctivitis sicca in rheumatoid arthritis. Clin Rheumatol 1988, 7:237-241.
39. Brun JG, Madland TM, Jonsson R: A prospective study of sicca symptoms in patients with rheumatoid arthritis. Arthritis Rheum 2003, 49:187-192.
40. Forstermann U, Kleinert H, Gash I, Schwarz P, Closs EI, Dun NJ: Expression and expressional control of nitric oxide synthases in various cell types. Adv Pharmacol 1995, 34:171-186.
41. Weinberg JB: Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes - a review. Mol Med 1998, 4:557-591.
42. Weinberg JB: Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. Environ Health Perspect 1998, 106(Suppl 5) 1131-1137.
43. Sakurai H, Kohsaka H, Liu MF, Higashiyama H, Hirata Y, Kanno K, Saito I, Miyasaka N: Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest 1995, 96:2357-2363.
44. 15N]citrulline labeling. Proc Natl Acad Sci USA 1996, 93:z11460-11465.
45. Beckman JS: Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 1996, 9:836-844.
46. Granger DL, Miller WC, Hibbs JB Jr: Methods of analyzing nitric oxide production in the immune response. In Methods in Nitric Oxide Research Edited by: Feelisch M, Stamler JS. New York: John Wiley & Sons Ltd; 1996:603-617.
47. Granger DL, Taintor RR, Boockvar KS, Hibbs JB Jr: Determination of nitrate and nitrite in biological samples using bacterial nitrate reductase coupled with the Griess reaction. Methods 1995, 7 78-83.
48. Suzuki H, Ikenaga H, Hishikawa K, Nakaki T, Kato R, Surata T: Increases in nitrite/nitrate excretion in the urine as an indicator of the release of endothelium-derived relaxing factor during elevation of blood pressure. Clin Sci 1992, 82:631-634.
49. Bode-Böger SM, Böger HR, Creutzig A, Tsikas D, Gutzki F-M, Alexander K, Frölich JC: L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin Sci 1994, 87:303-310.
50. Suto T, Losonczy G, Qiu CB, Hill C, Samsell L, Ruby J, Charon N, Venuto R, Baylis C: Acute changes in urinary excretion of nitrite plus nitrate do not necessarily predict renal vascular NO production. Kidney Int 1995, 48:1272-1277.
51. Mackenzie IMJ, Ekangaki A, Young JD, Garrard CS: Effect of renal function on serum nitrogen oxide concentrations. Clin Chem 1996, 42:440-444.
52. Talal N: Sjogren's syndrome, lymphoproliferation, and renal tubular acidosis. Ann Intern Med 1971, 74:633-634.
53. Niederstadt C, Happ T, Tatsis E, Schnabel A, Steinhoff J: Glomerular and tubular proteinuria as markers of nephropathy in rheumatoid arthritis. Rheumatology (Oxford) 1999, 38:28-33.