P53-dependent radiobiological responses to internalised indium-111 in human cells

Nuclear Medicine and Biology

Volumn 40, Issue 1, 2013, Pages 73-79

  Weeks, Amanda J ^a   Blower, Philip J ^b,c   Lloyd, Daniel R ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

111In ; Auger electrons; Cytotoxicity; DNA damage; P53

Indexed keywords

8 QUINOLINOL INDIUM IN 111; INDIUM 111; PROTEIN P21; PROTEIN P53;

ARTICLE; AUGER ELECTRON SPECTROSCOPY; CELL TRANSPORT; CLONOGENESIS; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FIBROSARCOMA; HUMAN; HUMAN CELL; IC 50; MOLECULAR CLONING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOBIOLOGY; RNA INTERFERENCE; SENSITIVITY ANALYSIS; TUMOR CELL LINE;

BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDIUM RADIOISOTOPES; RADIOBIOLOGY; RADIOPHARMACEUTICALS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84871921170     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.08.009     Document Type: Article

References (42)

1. Boehme K.A., Blattner C. Regulation of p53 - insights into a complex process. Crit Rev Biochem Mol Biol 2009, 44:367-392.
2. Hussain S.P., Harris C.C. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res 1998, 58:4023-4037.
3. Haveles K.S., Georgakilas A.G., Sideris E.G., Sophianopoulou V. Effects of radical scavengers on radiation-induced DNA double strand breaks. Int J Radiat Biol 2000, 76:51-59.
4. Dahm-Daphi J., Sass C., Alberti W. Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells. Int J Radiat Biol 2000, 76:67-75.
5. Martinez G.R., Loureiro A.P., Marques S.A., Marques S.A., Miyamoto S., Yamaguchi L.F., et al. Oxidative and alkylating damage in DNA. Mutat Res 2003, 544:115-127.
6. Gatz S.A., Wiesmuller L. p53 in recombination and repair. Cell Death Differ 2006, 13:1003-1016.
7. Offer H., Erez N., Zurer I., Tang X., Milyavsky M., Goldfinger N., et al. The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis 2002, 23:1025-1032.
8. Fan J., Bertino J.R. Modulation of cisplatinum cytotoxicity by p53: effect of p53-mediated apoptosis and DNA repair. Mol Pharmacol 1999, 56:966-972.
9. Fan S., Smith M.L., Rivet D.J., Duba D., Zhan Q., Kohn K.W., et al. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res 1995, 55:1649-1654.
10. Park C.M., Park M.J., Kwak H.J., Moon S.I., Yoo D.H., Lee H.C., et al. Induction of p53-mediated apoptosis and recovery of chemosensitivity through p53 transduction in human glioblastoma cells by cisplatin. Int J Oncol 2006, 28:119-125.
11. Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L., Carey T.E., et al. Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localisation signal of p53. Clin Cancer Res 2005, 11:6845-6852.
12. Bhana S., Lloyd D.R. The role of p53 in DNA damage-mediated cytotoxicity overrides its ability to regulate nucleotide excision repair in human fibroblasts. Mutagenesis 2008, 23:43-50.
13. Wani M.A., Zhu Q.Z., El-Mahdy M., Wani A.A. Influence of p53 tumour suppressor protein on bias of DNA repair and apoptotic response in human cells. Carcinogenesis 1999, 20:765-772.
14. El-Mahdy M.A., Hamada F.M., Wani M.A., Zhu Q., Wani A.A. p53-degradation by HPV-E6 preferentially affects the removal of cyclobutane pyrimidine dimers for non-transcribed strand and sensitizes mammary epithelial cells to UV-irradiation. Mutat Res 2000, 459:135-145.
15. Lackinger D., Eichorn U., Kaina B. Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-fos, p53 or both. Mutagenesis 2001, 16:233-241.
16. Kaltsas G.A., Papadogias D., Makras P., Grossman A.B. Treatment of advanced neuroendocrine tumours with radiolabelled somatostatin analogues. Endocr Relat Cancer 2005, 12:683-699.
17. 111In-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR. J Nucl Med 2000, 41:429-438.
18. Chen P., Mrkobrada M., Vallis K.A., Cameron R., Sandhu J., Hendler A., et al. Comparative antiproliferative effects of (111)In-DTPA-hEGF, chemotherapeutic agents and gamma-radiation on EGFR-positive breast cancer cells. Nucl Med Biol 2002, 29:693-699.
19. Reilly R.M., Chen P., Wang J., Scollard D., Cameron R., Vallis K.A. Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an Auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer. J Nucl Med 2006, 47:1023-1031.
20. 111In]-labelled leucocytes for localisation of abscesses. Lancet 1976, 2:1056-1058.
21. 111In-labeled leukocytes as an abscess imaging agent in dogs. Radiology 1976, 119:731.
22. Rannie G.H., Thakur M.L., Ford W.L. An experimental comparison of radioactive labels with potential application to lymphocyte migration studies in patients. Clin Exp Immunol 1977, 29:509-514.
23. Wagstaff J., Gibson C., Thatcher N., Ford W.L., Sharma H., Benson W., et al. A method for following human lymphocyte traffic using indium-111 oxine labelling. Clin Exp Immunol 1981, 43:435-442.
24. Hartmann A., Agurell E., Beevers C., Brendler-Schwaab S., Burlinson B., Clay P., et al. Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop. Mutagenesis 2003, 18:45-51.
25. Weeks A.J., Paul R.L., Marsden P.K., Blower P.J., Lloyd D.R. Radiobiological effects of hypoxia-dependent uptake of copper-64-ATSM: enhanced DNA damage and cytotoxicity in hypoxic cells. Eur J Nucl Med Mol Imaging 2010, 37:330-338.
26. Olive P.L., Banath J.P., Durand R.E. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat Res 1990, 122:86-94.
27. Yun S., Lie A.C.C., Porter A.C. Discriminatory suppression of homologous recombination by p53. Nucleic Acids Res 2004, 32:6479-6489.
28. Eiblmaier M., Meyer L.A., Anderson C.J. The role of p53 in the trafficking of copper-64 to tumour cell nuclei. Cancer Biol Ther 2008, 7:63-69.
29. Nguyen K., Parry J.J., Rogers B.E., Anderson C.J. Evaluation of copper-64-labeled somatostatin agonists and antagonist in SSTr2-transfected cell lines that are positive and negative for p53: implications for cancer therapy. Nucl Med Biol 2012, 39:187-197.
30. Slupphaug G., Kavli B., Krokan H.E. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res 2003, 531:231-251.
31. Zhou J., Ahn J., Wilson S.H., Prives C. A role for p53 in base excision repair. EMBO J 2001, 20:914-923.
32. Zurer I., Hofseth L.J., Cohen Y., Xu-Welliver M., Hussain S.P., Harris C.C., et al. The role of p53 in base excision repair following genotoxic stress. Carcinogenesis 2004, 25:11-19.
33. Offer H., Zurer I., Banfalvi G., Reha'k M., Falcovitz A., Milyavsky M., et al. p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. Cancer Res 2001, 61:88-96.
34. Nunez M.I., McMillan T.J., Valenzuela M.T., de Almodovar JM Ruiz, Pedraza V. Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiother Oncol 1996, 39:155-165.
35. Dikomey E., Dahm-Daphi J., Brammer I., Martensen R., Kaina B. Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int J Radiat Biol 1998, 73:269-278.
36. Akyuz N., Boehden G.S., Susse S., Rimek A., Preuss U., Scheidtmann K.H., et al. DNA substrate dependence of p53-mediated regulation of double-strand break repair. Mol Cell Biol 2002, 22:6306-6317.
37. Tang W., Willers H., Powell S.N. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res 1999, 59:2562-2565.
38. Dahm-Daphi J., Hubbe P., Horvath F., El-Awady R.A., Bouffard K.E., Powell S.N., et al. Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene 2005, 24:1663-1672.
39. Kim J.S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M., Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol 2005, 170:341-347.
40. Schuler M., Bossy-Wetzel E., Goldstein J.C., Fitzgerald P., Green D.R. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem 2000, 275:7337-7342.
41. Pawlik T.M., Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004, 59:928-942.
42. Lee Y.J., Chung J.K., Kang J.H., Jeong J.M., Lee D.S., Lee M.C. Wild-type p53 enhances the cytotoxic effect of radionuclide gene therapy using sodium iodide symporter in a murine anaplastic thyroid cancer model. Eur J Nucl Med Mol Imaging 2010, 37:235-241.