메뉴 건너뛰기




Volumn 6, Issue 1, 2012, Pages

Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: A comparative molecular field analysis (CoMFA) revisited study

Author keywords

1 (3,5 diaryl 4,5 dihydropyrazol 1 yl)ethanethione; 3,5 diaryl 4,5 dihydropyrazole 1 carbothioamide; Antitumor; CoMFA; QSAR

Indexed keywords


EID: 84871920818     PISSN: None     EISSN: 1752153X     Source Type: Journal    
DOI: 10.1186/1752-153X-6-50     Document Type: Article
Times cited : (3)

References (32)
  • 1
    • 0032706396 scopus 로고    scopus 로고
    • Novel anti-cancer agents in development: exciting prospects and new challenges
    • 10.1053/ctrv.1999.0134, 10544074
    • Seymour L. Novel anti-cancer agents in development: exciting prospects and new challenges. Cancer Treat Rev 1999, 25:301-312. 10.1053/ctrv.1999.0134, 10544074.
    • (1999) Cancer Treat Rev , vol.25 , pp. 301-312
    • Seymour, L.1
  • 2
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • 10.1016/0092-8674(90)90801-K, 2158859
    • Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990, 61(2):203-212. 10.1016/0092-8674(90)90801-K, 2158859.
    • (1990) Cell , vol.61 , Issue.2 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 3
    • 0033786922 scopus 로고    scopus 로고
    • Protein tyrosine kinase structure and function
    • 10.1146/annurev.biochem.69.1.373, 10966463
    • Hubbard SR, Till JH. Protein tyrosine kinase structure and function. Annu Rev Biochem 2000, 69:373-398. 10.1146/annurev.biochem.69.1.373, 10966463.
    • (2000) Annu Rev Biochem , vol.69 , pp. 373-398
    • Hubbard, S.R.1    Till, J.H.2
  • 5
    • 0026546505 scopus 로고
    • Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides
    • 10.1021/jm00083a017, 1548681
    • Manfredini S, Bazzanini R, Baraldi PG, Guarneri M, Simoni D, Marongiu ME, Pani A, Tramontano E, La Colla P. Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides. J Med Chem 1992, 35(5):917-924. 10.1021/jm00083a017, 1548681.
    • (1992) J Med Chem , vol.35 , Issue.5 , pp. 917-924
    • Manfredini, S.1    Bazzanini, R.2    Baraldi, P.G.3    Guarneri, M.4    Simoni, D.5    Marongiu, M.E.6    Pani, A.7    Tramontano, E.8    La Colla, P.9
  • 7
    • 20444415984 scopus 로고    scopus 로고
    • Identification of antitumor activity of pyrazole oxime ethers
    • 10.1016/j.bmcl.2005.03.082, 15922597
    • Park HJ, Lee K, Park SJ, Ahn B, Lee JC, Cho H, Lee KI. Identification of antitumor activity of pyrazole oxime ethers. Bioorg Med Chem Lett 2005, 15(13):3307-3312. 10.1016/j.bmcl.2005.03.082, 15922597.
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.13 , pp. 3307-3312
    • Park, H.J.1    Lee, K.2    Park, S.J.3    Ahn, B.4    Lee, J.C.5    Cho, H.6    Lee, K.I.7
  • 8
    • 0026414089 scopus 로고
    • Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation
    • Comber RN, Gray RJ, Secrist JA. Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation. Carbohydr Res 1991, 216:441-452.
    • (1991) Carbohydr Res , vol.216 , pp. 441-452
    • Comber, R.N.1    Gray, R.J.2    Secrist, J.A.3
  • 9
    • 77957985488 scopus 로고    scopus 로고
    • A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors
    • 10.1016/j.bmc.2010.08.033, 20851615
    • Elgazwy AS, Ismail NS, Elzahabi HS. A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors. Bioorg Med Chem 2010, 18(21):7639-7650. 10.1016/j.bmc.2010.08.033, 20851615.
    • (2010) Bioorg Med Chem , vol.18 , Issue.21 , pp. 7639-7650
    • Elgazwy, A.S.1    Ismail, N.S.2    Elzahabi, H.S.3
  • 10
    • 0020029309 scopus 로고
    • Pyrido[2,3-d]pyrimidines. The synthesis of the 5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid
    • Temple C, Elliot RD, Montgomery JA. Pyrido[2,3-d]pyrimidines. The synthesis of the 5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. J Org Chem 1982, 47:761-764.
    • (1982) J Org Chem , vol.47 , pp. 761-764
    • Temple, C.1    Elliot, R.D.2    Montgomery, J.A.3
  • 12
    • 0021345608 scopus 로고
    • Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues
    • 10.1016/0006-2952(84)90472-6, 6367748
    • Stone SR, Montgomery JA, Morrison JF. Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues. Biochem Pharmacol 1984, 33(2):175-179. 10.1016/0006-2952(84)90472-6, 6367748.
    • (1984) Biochem Pharmacol , vol.33 , Issue.2 , pp. 175-179
    • Stone, S.R.1    Montgomery, J.A.2    Morrison, J.F.3
  • 13
    • 0018874182 scopus 로고
    • Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido [2,3-d]pyrimidine
    • 10.1021/jm00177a025, 6928967
    • Grivsky EM, Lee S, Sigel CW, Duch DS, Nichol CA. Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido [2,3-d]pyrimidine. J Med Chem 1980, 23(3):327-329. 10.1021/jm00177a025, 6928967.
    • (1980) J Med Chem , vol.23 , Issue.3 , pp. 327-329
    • Grivsky, E.M.1    Lee, S.2    Sigel, C.W.3    Duch, D.S.4    Nichol, C.A.5
  • 15
    • 0025095288 scopus 로고
    • Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid
    • 10.1021/jm00164a033, 2299633
    • DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM. Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid. J Med Chem 1990, 33(2):673-677. 10.1021/jm00164a033, 2299633.
    • (1990) J Med Chem , vol.33 , Issue.2 , pp. 673-677
    • DeGraw, J.I.1    Christie, P.H.2    Kisliuk, R.L.3    Gaumont, Y.4    Sirotnak, F.M.5
  • 16
    • 0021813844 scopus 로고
    • Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin
    • 10.1021/jm00145a012, 4009615
    • Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem 1985, 28(7):914-921. 10.1021/jm00145a012, 4009615.
    • (1985) J Med Chem , vol.28 , Issue.7 , pp. 914-921
    • Taylor, E.C.1    Harrington, P.J.2    Fletcher, S.R.3    Beardsley, G.P.4    Moran, R.G.5
  • 17
    • 80051483748 scopus 로고    scopus 로고
    • Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates
    • Havrylyuk D, Kovach N, Zimenkovsky B, Vasylenko O, Lesyk R. Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates. Arch Pharm (Weinheim) 2011, 344(8):514-22.
    • (2011) Arch Pharm (Weinheim) , vol.344 , Issue.8 , pp. 514-522
    • Havrylyuk, D.1    Kovach, N.2    Zimenkovsky, B.3    Vasylenko, O.4    Lesyk, R.5
  • 18
    • 67650392211 scopus 로고    scopus 로고
    • N-(3-Cyano-2-oxo-2,5,6,7,8,9-hexahydro-1 H-cyclohepta[b]pyridin-1-yl)-4-methylbenzenesulfonamide
    • Elgemeie GH, Mohamed MA, Jones PG. N-(3-Cyano-2-oxo-2,5,6,7,8,9-hexahydro-1 H-cyclohepta[b]pyridin-1-yl)-4-methylbenzenesulfonamide. Acta Crystallogr E 2002, 58:1293-1295.
    • (2002) Acta Crystallogr E , vol.58 , pp. 1293-1295
    • Elgemeie, G.H.1    Mohamed, M.A.2    Jones, P.G.3
  • 19
    • 37049068042 scopus 로고
    • Aldol condensation in the absence of solvent:acceleration of the reaction and enhancement of the stereochemistry
    • Toda F, Tanaka K, Hami K. Aldol condensation in the absence of solvent:acceleration of the reaction and enhancement of the stereochemistry. J Chem Soc Perkin Trans 1990, 1:3207-3209.
    • (1990) J Chem Soc Perkin Trans , vol.1 , pp. 3207-3209
    • Toda, F.1    Tanaka, K.2    Hami, K.3
  • 20
    • 4344642274 scopus 로고    scopus 로고
    • Solvent-free synthesis
    • Palleros DR. Solvent-free synthesis. J Chem Ed 2004, 81:1345-1347.
    • (2004) J Chem Ed , vol.81 , pp. 1345-1347
    • Palleros, D.R.1
  • 21
    • 2342502398 scopus 로고    scopus 로고
    • Kinetics of crossed aldol condensations in high-temperature water
    • Comisar CM, Savage PE. Kinetics of crossed aldol condensations in high-temperature water. Green Chem 2004, 6:227-231.
    • (2004) Green Chem , vol.6 , pp. 227-231
    • Comisar, C.M.1    Savage, P.E.2
  • 23
    • 0027548454 scopus 로고
    • A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists
    • 10.1007/BF00141577, 8097240
    • Martin YC, Bures MG, Danaher EA, DeLazzer J, Lico I, Pavlik PA. A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists. J Comput Aided Mol Des 1993, 7(1):83-102. 10.1007/BF00141577, 8097240.
    • (1993) J Comput Aided Mol Des , vol.7 , Issue.1 , pp. 83-102
    • Martin, Y.C.1    Bures, M.G.2    Danaher, E.A.3    DeLazzer, J.4    Lico, I.5    Pavlik, P.A.6
  • 26
    • 0003476917 scopus 로고    scopus 로고
    • Dordrecht: Kluwer, Kubinyi H, Folkers G, Martin YC, 3
    • 3D QSAR in Drug Design. Vols. 2 1998, Dordrecht: Kluwer, Kubinyi H, Folkers G, Martin YC, 3.
    • (1998) 3D QSAR in Drug Design. Vols. 2
  • 30
    • 0024312538 scopus 로고
    • Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm
    • 10.1093/jnci/81.14.1088, 2738938
    • Paull KD, Shoemaker RH, Hodes L, Monks A, Scudiero DA, Rubinstein L, Plowman J, Boyd MR. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst 1989, 81(14):1088-1092. 10.1093/jnci/81.14.1088, 2738938.
    • (1989) J Natl Cancer Inst , vol.81 , Issue.14 , pp. 1088-1092
    • Paull, K.D.1    Shoemaker, R.H.2    Hodes, L.3    Monks, A.4    Scudiero, D.A.5    Rubinstein, L.6    Plowman, J.7    Boyd, M.R.8
  • 32
    • 38949173868 scopus 로고    scopus 로고
    • Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel
    • 10.1111/j.1349-7006.2007.00700.x, 18271941
    • Al-Abd AM, Lee JH, Kim SY, Kun N, Kuh HJ. Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel. Cancer Sci 2008, 99(2):423-431. 10.1111/j.1349-7006.2007.00700.x, 18271941.
    • (2008) Cancer Sci , vol.99 , Issue.2 , pp. 423-431
    • Al-Abd, A.M.1    Lee, J.H.2    Kim, S.Y.3    Kun, N.4    Kuh, H.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.