-
1
-
-
0032706396
-
Novel anti-cancer agents in development: exciting prospects and new challenges
-
10.1053/ctrv.1999.0134, 10544074
-
Seymour L. Novel anti-cancer agents in development: exciting prospects and new challenges. Cancer Treat Rev 1999, 25:301-312. 10.1053/ctrv.1999.0134, 10544074.
-
(1999)
Cancer Treat Rev
, vol.25
, pp. 301-312
-
-
Seymour, L.1
-
2
-
-
0025343230
-
Signal transduction by receptors with tyrosine kinase activity
-
10.1016/0092-8674(90)90801-K, 2158859
-
Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990, 61(2):203-212. 10.1016/0092-8674(90)90801-K, 2158859.
-
(1990)
Cell
, vol.61
, Issue.2
, pp. 203-212
-
-
Ullrich, A.1
Schlessinger, J.2
-
3
-
-
0033786922
-
Protein tyrosine kinase structure and function
-
10.1146/annurev.biochem.69.1.373, 10966463
-
Hubbard SR, Till JH. Protein tyrosine kinase structure and function. Annu Rev Biochem 2000, 69:373-398. 10.1146/annurev.biochem.69.1.373, 10966463.
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 373-398
-
-
Hubbard, S.R.1
Till, J.H.2
-
4
-
-
24944543833
-
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors
-
10.1021/jm050458h, 16162008
-
Dai Y, Guo Y, Frey RR, Ji Z, Curtin ML, Ahmed AA, Albert DH, Arnold L, Arries SS, Barlozzari T, Bauch JL, Bouska JJ, Bousquet PF, Cunha GA, Glaser KB, Guo J, Li J, Marcotte PA, Marsh KC, Moskey MD, Pease LJ, Stewart KD, Stoll VS, Tapang P, Wishart N, Davidsen SK, Michaelides MR. Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. J Med Chem 2005, 48(19):6066-6083. 10.1021/jm050458h, 16162008.
-
(2005)
J Med Chem
, vol.48
, Issue.19
, pp. 6066-6083
-
-
Dai, Y.1
Guo, Y.2
Frey, R.R.3
Ji, Z.4
Curtin, M.L.5
Ahmed, A.A.6
Albert, D.H.7
Arnold, L.8
Arries, S.S.9
Barlozzari, T.10
Bauch, J.L.11
Bouska, J.J.12
Bousquet, P.F.13
Cunha, G.A.14
Glaser, K.B.15
Guo, J.16
Li, J.17
Marcotte, P.A.18
Marsh, K.C.19
Moskey, M.D.20
Pease, L.J.21
Stewart, K.D.22
Stoll, V.S.23
Tapang, P.24
Wishart, N.25
Davidsen, S.K.26
Michaelides, M.R.27
more..
-
5
-
-
0026546505
-
Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides
-
10.1021/jm00083a017, 1548681
-
Manfredini S, Bazzanini R, Baraldi PG, Guarneri M, Simoni D, Marongiu ME, Pani A, Tramontano E, La Colla P. Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides. J Med Chem 1992, 35(5):917-924. 10.1021/jm00083a017, 1548681.
-
(1992)
J Med Chem
, vol.35
, Issue.5
, pp. 917-924
-
-
Manfredini, S.1
Bazzanini, R.2
Baraldi, P.G.3
Guarneri, M.4
Simoni, D.5
Marongiu, M.E.6
Pani, A.7
Tramontano, E.8
La Colla, P.9
-
6
-
-
0029906268
-
Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles
-
Manfredini S, Bazzanini R, Baraldi PG, Bonora M, Marangoni M, Simoni D, Pani A, Scintu F, Pinna E, Pisano L, La Colla P. Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles. Anticancer Drug Des 1996, 11(3):193-204.
-
(1996)
Anticancer Drug Des
, vol.11
, Issue.3
, pp. 193-204
-
-
Manfredini, S.1
Bazzanini, R.2
Baraldi, P.G.3
Bonora, M.4
Marangoni, M.5
Simoni, D.6
Pani, A.7
Scintu, F.8
Pinna, E.9
Pisano, L.10
La Colla, P.11
-
7
-
-
20444415984
-
Identification of antitumor activity of pyrazole oxime ethers
-
10.1016/j.bmcl.2005.03.082, 15922597
-
Park HJ, Lee K, Park SJ, Ahn B, Lee JC, Cho H, Lee KI. Identification of antitumor activity of pyrazole oxime ethers. Bioorg Med Chem Lett 2005, 15(13):3307-3312. 10.1016/j.bmcl.2005.03.082, 15922597.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, Issue.13
, pp. 3307-3312
-
-
Park, H.J.1
Lee, K.2
Park, S.J.3
Ahn, B.4
Lee, J.C.5
Cho, H.6
Lee, K.I.7
-
8
-
-
0026414089
-
Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation
-
Comber RN, Gray RJ, Secrist JA. Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation. Carbohydr Res 1991, 216:441-452.
-
(1991)
Carbohydr Res
, vol.216
, pp. 441-452
-
-
Comber, R.N.1
Gray, R.J.2
Secrist, J.A.3
-
9
-
-
77957985488
-
A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors
-
10.1016/j.bmc.2010.08.033, 20851615
-
Elgazwy AS, Ismail NS, Elzahabi HS. A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors. Bioorg Med Chem 2010, 18(21):7639-7650. 10.1016/j.bmc.2010.08.033, 20851615.
-
(2010)
Bioorg Med Chem
, vol.18
, Issue.21
, pp. 7639-7650
-
-
Elgazwy, A.S.1
Ismail, N.S.2
Elzahabi, H.S.3
-
10
-
-
0020029309
-
Pyrido[2,3-d]pyrimidines. The synthesis of the 5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid
-
Temple C, Elliot RD, Montgomery JA. Pyrido[2,3-d]pyrimidines. The synthesis of the 5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. J Org Chem 1982, 47:761-764.
-
(1982)
J Org Chem
, vol.47
, pp. 761-764
-
-
Temple, C.1
Elliot, R.D.2
Montgomery, J.A.3
-
11
-
-
0021089347
-
Synthesis and biological activity of L-5-deazafolic acid and L-deazaaminopterin: synthetic strategies to 5-deazapteridines
-
Taylor EC, Palmer DC, George TJ, Fletcher SR, Tseng CP, Harrington PJ, Beardsley GP, Dumas DJ, Rosowsky A, Wick M. Synthesis and biological activity of L-5-deazafolic acid and L-deazaaminopterin: synthetic strategies to 5-deazapteridines. J Org Chem 1983, 48:4852-4860.
-
(1983)
J Org Chem
, vol.48
, pp. 4852-4860
-
-
Taylor, E.C.1
Palmer, D.C.2
George, T.J.3
Fletcher, S.R.4
Tseng, C.P.5
Harrington, P.J.6
Beardsley, G.P.7
Dumas, D.J.8
Rosowsky, A.9
Wick, M.10
-
12
-
-
0021345608
-
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues
-
10.1016/0006-2952(84)90472-6, 6367748
-
Stone SR, Montgomery JA, Morrison JF. Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues. Biochem Pharmacol 1984, 33(2):175-179. 10.1016/0006-2952(84)90472-6, 6367748.
-
(1984)
Biochem Pharmacol
, vol.33
, Issue.2
, pp. 175-179
-
-
Stone, S.R.1
Montgomery, J.A.2
Morrison, J.F.3
-
13
-
-
0018874182
-
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido [2,3-d]pyrimidine
-
10.1021/jm00177a025, 6928967
-
Grivsky EM, Lee S, Sigel CW, Duch DS, Nichol CA. Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido [2,3-d]pyrimidine. J Med Chem 1980, 23(3):327-329. 10.1021/jm00177a025, 6928967.
-
(1980)
J Med Chem
, vol.23
, Issue.3
, pp. 327-329
-
-
Grivsky, E.M.1
Lee, S.2
Sigel, C.W.3
Duch, D.S.4
Nichol, C.A.5
-
14
-
-
0345455149
-
Advances
-
New York: Marcel Dekker, Rosowsky A, 1
-
Ensminger WD, Grindey GB, Hoglind JA. Advances. Cancer Chemotherapy. Vol 1979, 61-109. New York: Marcel Dekker, Rosowsky A, 1.
-
(1979)
Cancer Chemotherapy. Vol
, pp. 61-109
-
-
Ensminger, W.D.1
Grindey, G.B.2
Hoglind, J.A.3
-
15
-
-
0025095288
-
Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid
-
10.1021/jm00164a033, 2299633
-
DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM. Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid. J Med Chem 1990, 33(2):673-677. 10.1021/jm00164a033, 2299633.
-
(1990)
J Med Chem
, vol.33
, Issue.2
, pp. 673-677
-
-
DeGraw, J.I.1
Christie, P.H.2
Kisliuk, R.L.3
Gaumont, Y.4
Sirotnak, F.M.5
-
16
-
-
0021813844
-
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin
-
10.1021/jm00145a012, 4009615
-
Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem 1985, 28(7):914-921. 10.1021/jm00145a012, 4009615.
-
(1985)
J Med Chem
, vol.28
, Issue.7
, pp. 914-921
-
-
Taylor, E.C.1
Harrington, P.J.2
Fletcher, S.R.3
Beardsley, G.P.4
Moran, R.G.5
-
17
-
-
80051483748
-
Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates
-
Havrylyuk D, Kovach N, Zimenkovsky B, Vasylenko O, Lesyk R. Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates. Arch Pharm (Weinheim) 2011, 344(8):514-22.
-
(2011)
Arch Pharm (Weinheim)
, vol.344
, Issue.8
, pp. 514-522
-
-
Havrylyuk, D.1
Kovach, N.2
Zimenkovsky, B.3
Vasylenko, O.4
Lesyk, R.5
-
18
-
-
67650392211
-
N-(3-Cyano-2-oxo-2,5,6,7,8,9-hexahydro-1 H-cyclohepta[b]pyridin-1-yl)-4-methylbenzenesulfonamide
-
Elgemeie GH, Mohamed MA, Jones PG. N-(3-Cyano-2-oxo-2,5,6,7,8,9-hexahydro-1 H-cyclohepta[b]pyridin-1-yl)-4-methylbenzenesulfonamide. Acta Crystallogr E 2002, 58:1293-1295.
-
(2002)
Acta Crystallogr E
, vol.58
, pp. 1293-1295
-
-
Elgemeie, G.H.1
Mohamed, M.A.2
Jones, P.G.3
-
19
-
-
37049068042
-
Aldol condensation in the absence of solvent:acceleration of the reaction and enhancement of the stereochemistry
-
Toda F, Tanaka K, Hami K. Aldol condensation in the absence of solvent:acceleration of the reaction and enhancement of the stereochemistry. J Chem Soc Perkin Trans 1990, 1:3207-3209.
-
(1990)
J Chem Soc Perkin Trans
, vol.1
, pp. 3207-3209
-
-
Toda, F.1
Tanaka, K.2
Hami, K.3
-
20
-
-
4344642274
-
Solvent-free synthesis
-
Palleros DR. Solvent-free synthesis. J Chem Ed 2004, 81:1345-1347.
-
(2004)
J Chem Ed
, vol.81
, pp. 1345-1347
-
-
Palleros, D.R.1
-
21
-
-
2342502398
-
Kinetics of crossed aldol condensations in high-temperature water
-
Comisar CM, Savage PE. Kinetics of crossed aldol condensations in high-temperature water. Green Chem 2004, 6:227-231.
-
(2004)
Green Chem
, vol.6
, pp. 227-231
-
-
Comisar, C.M.1
Savage, P.E.2
-
22
-
-
84986512474
-
CHARMM: a program for macromolecular energy, minimization, and dynamics calculations
-
Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M. CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J Comp Chem 1983, 4(2):187-217.
-
(1983)
J Comp Chem
, vol.4
, Issue.2
, pp. 187-217
-
-
Brooks, B.R.1
Bruccoleri, R.E.2
Olafson, B.D.3
States, D.J.4
Swaminathan, S.5
Karplus, M.6
-
23
-
-
0027548454
-
A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists
-
10.1007/BF00141577, 8097240
-
Martin YC, Bures MG, Danaher EA, DeLazzer J, Lico I, Pavlik PA. A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists. J Comput Aided Mol Des 1993, 7(1):83-102. 10.1007/BF00141577, 8097240.
-
(1993)
J Comput Aided Mol Des
, vol.7
, Issue.1
, pp. 83-102
-
-
Martin, Y.C.1
Bures, M.G.2
Danaher, E.A.3
DeLazzer, J.4
Lico, I.5
Pavlik, P.A.6
-
26
-
-
0003476917
-
-
Dordrecht: Kluwer, Kubinyi H, Folkers G, Martin YC, 3
-
3D QSAR in Drug Design. Vols. 2 1998, Dordrecht: Kluwer, Kubinyi H, Folkers G, Martin YC, 3.
-
(1998)
3D QSAR in Drug Design. Vols. 2
-
-
-
28
-
-
0003820281
-
-
Greenwich: JAI Press, Charton M, I
-
Martin YC, Kim K-H, Lin CT. Advances in Quantitative Structure Property Relationships. Vol 1996, 1-52. Greenwich: JAI Press, Charton M, I.
-
(1996)
Advances in Quantitative Structure Property Relationships. Vol
, pp. 1-52
-
-
Martin, Y.C.1
Kim, K.-H.2
Lin, C.T.3
-
29
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
-
10.1093/jnci/83.11.757, 2041050
-
Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, Vaigro-Wolff A, Gray-Goodrich M, Campbell H, Mayo J, Boyd M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 1991, 83(11):757-766. 10.1093/jnci/83.11.757, 2041050.
-
(1991)
J Natl Cancer Inst
, vol.83
, Issue.11
, pp. 757-766
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
Shoemaker, R.4
Paull, K.5
Vistica, D.6
Hose, C.7
Langley, J.8
Cronise, P.9
Vaigro-Wolff, A.10
Gray-Goodrich, M.11
Campbell, H.12
Mayo, J.13
Boyd, M.14
-
30
-
-
0024312538
-
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm
-
10.1093/jnci/81.14.1088, 2738938
-
Paull KD, Shoemaker RH, Hodes L, Monks A, Scudiero DA, Rubinstein L, Plowman J, Boyd MR. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst 1989, 81(14):1088-1092. 10.1093/jnci/81.14.1088, 2738938.
-
(1989)
J Natl Cancer Inst
, vol.81
, Issue.14
, pp. 1088-1092
-
-
Paull, K.D.1
Shoemaker, R.H.2
Hodes, L.3
Monks, A.4
Scudiero, D.A.5
Rubinstein, L.6
Plowman, J.7
Boyd, M.R.8
-
31
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
10.1093/jnci/82.13.1107, 2359136
-
Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990, 82(13):1107-1112. 10.1093/jnci/82.13.1107, 2359136.
-
(1990)
J Natl Cancer Inst
, vol.82
, Issue.13
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
32
-
-
38949173868
-
Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel
-
10.1111/j.1349-7006.2007.00700.x, 18271941
-
Al-Abd AM, Lee JH, Kim SY, Kun N, Kuh HJ. Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel. Cancer Sci 2008, 99(2):423-431. 10.1111/j.1349-7006.2007.00700.x, 18271941.
-
(2008)
Cancer Sci
, vol.99
, Issue.2
, pp. 423-431
-
-
Al-Abd, A.M.1
Lee, J.H.2
Kim, S.Y.3
Kun, N.4
Kuh, H.J.5
|