Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity

Archives of Biochemistry and Biophysics

Volumn 529, Issue 2, 2013, Pages 55-65

  Di Salvo, Martino L ^a   Florio, Rita ^a   Paiardini, Alessandro ^a   Vivoli, Mirella ^a   D'Aguanno, Simona ^a   Contestabile, Roberto ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Catalytic promiscuity; Cyclosporin; Fold type I alanine racemase; Nonribosomal peptide synthesis; Protein evolution; Pyridoxal 5 phosphate

Indexed keywords

3 HYDROXYAMINO ACID; ALANINE; ALANINE RACEMASE; CYCLOSPORIN; DEXTRO ALANINE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCINE HYDROXYMETHYLTRANSFERASE; HYBRID PROTEIN; HYDROXYAMINO ACID; PYRIDOXAL 5 PHOSPHATE; THREONINE ALDOLASE; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME STRUCTURE; FUNGUS; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; RACEMIZATION; SEQUENCE HOMOLOGY; TOLYPOCLADIUM INFLATUM; TRANSAMINATION;

ALANINE RACEMASE; AMINO ACID SEQUENCE; ASCOMYCOTA; CATALYSIS; COMPUTER SIMULATION; CYCLOSPORINE; ENZYME ACTIVATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA;

BACTERIA (MICROORGANISMS); FUNGI; TOLYPOCLADIUM INFLATUM;

EID: 84871911425     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2012.11.011     Document Type: Article

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