Serine hydroxymethyltransferase: Role of Glu75 and evidence that serine is cleaved by a retroaldol mechanism

Biochemistry

Volumn 43, Issue 22, 2004, Pages 6865-6876

  Szebenyi, Doletha M E ^a   Musayev, Faik N ^b   Di Salvo, Martino L ^b   Safo, Martin K ^b   Schirch, Verne ^b  

^a Cornell University ^*  (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CATALYSIS; ENZYMES; FORMALDEHYDE; HYDROGEN BONDS; MUTAGENESIS;

MUTANTS; NUCLEOPHILIC DISPLACEMENT MECHANISM; REVERSIBLE INTERCONVERSION;

BIOCHEMISTRY;

ALDEHYDE; AMINO ACID; GLUTAMIC ACID; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; SERINE;

ARTICLE; CATALYSIS; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME MECHANISM; KINETICS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TEMPERATURE;

ALDEHYDES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; FORMYLTETRAHYDROFOLATES; GLUTAMIC ACID; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RABBITS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATES;

EID: 2642571803     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049791y     Document Type: Article

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