Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy

Sleep

Volumn 36, Issue 1, 2013, Pages 91-98

  Sorensen, Gertrud Laura ^a,b,c   Knudsen, Stine ^a   Petersen, Eva Rosa ^a   Kempfner, Jacob ^a,b,c   Gammeltoft, Steen ^a   Sorensen, Helge Bjarup Dissing ^c   Jennum, Poul ^a,b  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Arousal; Autonomic dysfunction; Heart rate response; Hypocretin 1; Narcolepsy

Indexed keywords

OREXIN A;

ADULT; AROUSAL; ARTICLE; AUTONOMIC DYSFUNCTION; CARDIOVASCULAR FUNCTION; CATAPLEXY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEART RATE; HUMAN; LEG MOVEMENT; MAJOR CLINICAL STUDY; MALE; NARCOLEPSY; NONREM SLEEP; PHENOTYPE; POLYSOMNOGRAPHY; PREDICTOR VARIABLE; PRIORITY JOURNAL; REM SLEEP; REST; SLEEP STAGE;

ADULT; AROUSAL; AUTONOMIC NERVOUS SYSTEM; FEMALE; HEART RATE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NARCOLEPSY; NEUROPEPTIDES; POLYSOMNOGRAPHY; SLEEP STAGES;

EID: 84871908378     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.2308     Document Type: Article

References (26)

1. Knudsen S, Jennum P, Alving J, Sheikh SP, Gammeltoft S. Validation of the ICSD-2 Criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. Sleep 2010;33:169-76.
2. Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998;18:9996- 10015.
3. Ciriello J, de Oliveira CVR. Cardiac effects of hypocretin-1 in nucleus ambiguus. Am J Physiol Regul Integr Comp Physiol 2003;284:R1611-20.
4. de Oliveira CVR, Rosas-Arellano MP, Solano-Flores LP, Ciriello J. Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract. Am J Physiol Heart Circ Physiol 2003; 284:H1369-77.
5. Samson WK, Gosnell B, Chang JK, Resch ZT, Murphy TC. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res 1999; 831:248-53. (Pubitemid 29336207)
6. Shirasaka T, Nakazato M, Matsukura S, Takasaki M, Kannan H. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 1999;277:R1780-5. (Pubitemid 30043787)
7. Fronczek R, Overeem S, Reijntjes R, Lammers GJ, van Dijk JG, Pijl H. Increased heart rate variability but normal resting metabolic rate in hypocretin/orexin-deficient human narcolepsy. J Clin Sleep Med 2008;4:248-54. (Pubitemid 352039436)
8. Grimaldi D, Pierangeli G, Barletta G, et al. Spectral analysis of heart rate variability reveals an enhanced sympathetic activity in narcolepsy with cataplexy. Clin Neurophys 2010;121:1142-7.
9. Dauvilliers Y, Pennestri MH, Whittom S, Lanfranchi PA, Montplaisir JY. Autonomic response to periodic leg movements during sleep in narcolep-sy- cataplexy. Sleep 2011;34:219-23.
10. Ferini-Strambi L, Spera A, Oldani A, et al. Autonomic function in narcolepsy: power spectrum analysis of heart rate variability. J Neurol 1997;244:252-5. (Pubitemid 27156475)
11. The International Classification of Sleep Disorders (ICSD)-Diagnostic and Coding Manual. 2nd ed. Westchester, IL: American Academy of Sleep Medicine, 2005.
12. Gosselin N, Michaud M, Carrier J, Lavigne G, Montplaisir J. Age difference in heart rate changes associated with micro-arousals in humans. Clin Neurophys 2002;113:1517-21.
13. Bonnet MH, Carley D, Guilleminault CG, et al. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992;15:173-84.
14. Iber C, Ancoli-Israel S, Chesson AL, Quan SF. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 1st ed. Westchester, IL: American Academy of Sleep Medicine, 2007.
15. Pan J, Tompkins WJ. A real-time QRS detection algorithm. IEEE Trans Biomed Eng 1985;32:230-6. (Pubitemid 15148852)
16. Fantini ML, Michaud M, Gosselin N, Lavigne G, Montplaisir J. Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation. Neurology 2002; 59:1889- 94.
17. Sforza E, Jouny C, Ibanez V. Cardiac activation during arousal in humans: further evidence for hierarchy in the arousal response. Clin Neurophysiol 2000; 111:1611-9. (Pubitemid 30646001)
18. Knudsen S, Gammeltoft S, Jennum PJ. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Brain 2010; 133:568-79.
19. Thannickal TC, Nienhuis R, Siegel JM. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep 2009;32:993-8.
20. Young JK, Wu M, Manaye KF, et al. Orexin stimulates breathing via medullary and spinal pathways. J Appl Physiol 2005;98:1387-95. (Pubitemid 40396515)
21. Dergacheva O, Philbin K, Batemana R, Mendelowitza D. Hypocretin-1 (orexin A) prevents the effects of hypoxia/hypercapnia and enhances the gabaergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus. Neuroscience 2011;175:18-23.
22. Shirasaka T, Kunitake T, Takasaki M, Kannan H. Neuronal effects of orexins: relevant to sympathetic and cardiovascular functions. Regul Pept 2002;104:91-5. (Pubitemid 34119378)
23. Bastianini S, Silvani A, Berteotti C, et al. Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice. Sleep 2011;34:213-8.
24. Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 6:991-7.
25. Sorensen GL, Kempfner J, Zoetmulder M, Sorensen HB, Jennum P. Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. Mov Disord 2012;27:888-94.
26. Braak H, Tredici KD, Rb U, de Vos RAI, Jansen Steur ENH, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211. (Pubitemid 36007810)