A Spider-Derived Kunitz-Type Serine Protease Inhibitor That Acts as a Plasmin Inhibitor and an Elastase Inhibitor

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Wan, Hu ^a   Lee, Kwang Sik ^a   Kim, Bo Yeon ^a   Zou, Feng Ming ^a   Yoon, Hyung Joo ^b   Je, Yeon Ho ^c   Li, Jianhong ^d   Jin, Byung Rae ^a  

^a Dong A University   (South Korea)

^b National Academy of Agricultural Science   (South Korea)

^c Seoul National University   (South Korea)

^d HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CHYMOTRYPSIN; CYSTEINE; ELASTASE INHIBITOR; FIBRINOLYTIC FACTOR; LEUKOCYTE ELASTASE; LYSINE; PLASMIN; PLASMIN INHIBITOR; SERINE PROTEINASE INHIBITOR; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; TRYPSIN;

AMINO ACID SEQUENCE; ARANEUS VENTRICOSUS; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN EXPRESSION; SPIDER;

AMINO ACID SEQUENCE; ANIMALS; ANTIFIBRINOLYTIC AGENTS; APROTININ; ARTHROPOD PROTEINS; BACULOVIRIDAE; CHYMOTRYPSIN; CONSERVED SEQUENCE; FACTOR XA; FIBRINOLYSIN; GENE EXPRESSION; MOLECULAR SEQUENCE DATA; PANCREATIC ELASTASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SERINE PROTEINASE INHIBITORS; SPIDERS; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; TRYPSIN; TRYPSIN INHIBITORS;

ARANEAE; ARANEUS VENTRICOSUS; HEXAPODA;

EID: 84871906969     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053343     Document Type: Article

References (37)

1. Laskowski M, Kato I, (1980) Protein inhibitors of proteinases. Annu Rev Biochem 49: 593-626.
2. Župunski V, Kordiš D, Gubenšek F, (2003) Adaptive evolution in the snake venom Kunitz/BPTI protein family. FEBS Lett 547: 131-136.
3. Yuan CH, He QY, Peng K, Diao JB, Tang X, et al. (2008) Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas. PLoS ONE 3: e3414.
4. Yang X, Wang Y, Lu Z, Zhai L, Jiang J, et al. (2009) A novel serine protease inhibitor from the venom of Vespa bicolor Fabricus. Comp Biochem Physiol B 153: 116-120.
5. Zhao R, Dai H, Qiu S, Li T, He Y, et al. (2011) SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. PLoS ONE 6: e27548.
6. Peigneur S, Billen B, Derua R, Waelkens E, Debaveye S, et al. (2011) A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem Pharmacol 82: 81-90.
7. Choo YM, Lee KS, Yoon HJ, Qiu Y, Wan H, et al. (2012) Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor. PLoS ONE 7: e32269.
8. Soares TS, Watanabe RMO, Tanaka-Azevedo AM, Torquato RJS, Lu S, et al. (2012) Expression and functional characterization of boophilin, a thrombin inhibitor from Rhipicephalus (Boophilus) microplus midgut. Vet Parasitol 187: 521-528.
9. Chang LS, Chung C, Huang HB, Lin SR, (2001) Purification and characterization of a chymotrypsin inhibitor from the venom of Ophiophagus hannah (king cobra). Biochem Biophys Res Commun 283: 862-867.
10. Zhou XD, Jin Y, Lu QM, Li DS, Zhu SW, et al. (2004) Purification, characterization and primary structure of a chymotrypsin inhibitor from Naja atra venom. Comp Biochem Physiol B 237: 219-214.
11. Wang H, Wang L, Zhou M, Yang M, Ma C, et al. (2012) Functional peptidomics of amphibian skin secretion: A novel Kunitz-type chymotrypsin inhibitor from the African hyperoliid frog, Kassina senegalensis. Biochimie 94: 891-899.
12. He YY, Liu SB, Lee WH, Qian JQ, Zhang Y, (2008) Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom. Peptides 29: 1692-1699.
13. Sasaki SD, Azzolini SS, Hirata IY, Andreotti R, Tanaka AS, (2004) Boophilus microplus tick larvae, a rich source of Kunitz type serine protease inhibitors. Biochimie 86: 643-649.
14. Chen ZY, Hu YT, Yang WS, He YW, Feng J, et al. (2012) Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem 287: 13813-13821.
15. Tsujimoto H, Kotsyfakis M, Francischetti IMB, Eum JH, Strand MR, et al. (2012) Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses. PLoS ONE 7: e29964.
16. Liang S, (2004) An overview toxins from venom of the Chinese bird spider Selenocosmia huwena Wang [= Ornithoctonus huwena (Wang)]. Toxicon 43: 575-585.
17. Masci PP, Whitaker AN, Sparrow LG, de Jersey J, Winzor DJ, et al. (2000) Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors that reduce bleeding in an animal model. Blood Coagul Fibrinolysis 11: 385-393.
18. Flight S, Johnson L, Trabi M, Gaffney P, Lavin M, et al. (2005) Comparison of textinin-1 with aprotinin as serine protease inhibitors and as antifibrinolytic agents. Pathophysiol Haemost Thromb 34: 188-193.
19. Flight SM, Johnson LA, Du QS, Warner RL, Trabi M, et al. (2009) Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss. British J Hematol 145: 207-211.
20. Corral-Rodríguez MÁ, Macedo-Ribeiro S, Pereira PJB, Fuentes-Prior P, (2009) Tick-derived Kunitz-type inhibitors as antihemostatic factors. Insect Biochem Mol Biol 39: 579-595.
21. Millers EKI, Trabi M, Masci PP, Lavin MF, de Jersey J, et al. (2009) Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textiles). FEBS J 276: 3163-3175.
22. Papayannopoulos IA, Biemann K, (1992) Amino acid sequence of a protease inhibitor isolated from Sarcophaga bullata determined by mass spectrometry. Protein Sci 1: 278-288.
23. Nirmala X, Mita K, Vanisree V, Žurovec M, Sehnal F, (2001) Identification of four small molecular mass proteins in the silk of Bombyx mori. Insect Mol Biol 10: 437-445.
24. Tschesche H, Beckmann J, Mehlich A, Schnabel E, Truscheit E, et al. (1987) Semisynthetic engineering of proteinase-inhibitor homologs. Biochim Biophys Acta 913: 97-101.
25. Vincent JP, Lazdunski M, (1973) The interaction between alpha-chymotrypsin and pancreatic trypsin inhibitor (Kunitz inhibitor). Kinetic and thermodynamic properties. Eur J Bjochem 38: 365-372.
26. Choo YM, Lee KS, Yoon HJ, Kim BY, Sohn MR, et al. (2010) Dual strategy of bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. PLoS ONE 5: e10393.
27. Qiu Y, Choo YM, Yoon HJ, Jia J, Cui Z, et al. (2011) Fibrin(ogen)olytic activity of bumblebee venom serine protease. Toxicol Appl Pharmacol 255: 207-213.
28. Alam SR, Newby DE, Henriksen PA, (2012) Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury from epithelium to endothelium. Biochem Pharmacol 83: 695-704.
29. Almonte AG, Sweatt JD, (2011) Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior. Brain Res 1407: 107-122.
30. Matsui T, Fujimura Y, Titani K, (2000) Snake venom proteases affecting hemostasis and thrombosis. Biochim Biophys Acta 1477: 146-156.
31. Sasaki SD, Tanaka AS, (2008) rBmTI-6, a Kunitz-BPTI domain protease inhibitor from the tick Boophilus microplus, its cloning, expression and biochemical characterization. Vet Parasitol 155: 133-141.
32. Lee KS, Chung EH, Han JH, Sohn HD, Jin BR, (2003) cDNA cloning of a defender against apoptotic cell death 1 (DAD1) homologue, responsive to external temperature stimulus from the spider, Araneus ventricosus. Comp Biochem Physiol B 135: 117-123.
33. Lee KS, Kim BY, Je YH, Woo SD, Sohn HD, et al. (2007) Molecular cloning and expression of the C-terminus of spider flagelliform silk protein from Araneus ventricosus. J Biosci 32: 705-712.
34. Lee KS, Kim BY, Kim DH, Jin BR, (2012) Molecular cloning and characterization of the partial major ampullate silk protein gene from the spider Araneus ventricosus. J Asia-Pac Entomol 15: 641-646.
35. Je YH, Chang JH, Choi JY, Roh JY, Jin BR, et al. (2001) A defective viral genome maintained in Escherichia coli for the generation of baculovirus expression vectors. Biotechnol Lett 23: 575-582.
36. Tessier DC, Thomas DY, Khouri HE, Laliberté F, Vernet T, (1991) Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptide. Gene 98: 177-183.
37. Sinauridze EI, Romanov AN, Gribkova IV, Kondakova OA, Surov SS, et al. (2011) New synthetic thrombin inhibitors: molecular design and experimental verification. PLoS ONE 6: e19969.